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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to nitrosative stress
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Accession:GO:1990442 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
Synonyms:exact_synonym: nitrosative stress-induced intrinsic apoptotic signaling pathway
 related_synonym: nitrosative stress-induced apoptosis

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intrinsic apoptotic signaling pathway in response to nitrosative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA damage inducible transcript 3 involved_in ISO (MGI:5784990|PMID:14752510) ParkinsonsUK-UCL PMID:14752510 MGI:5784990 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513 		JBrowse link
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISO (PMID:14752510) ParkinsonsUK-UCL PMID:14752510 NCBI chrNW_004955472:2,604,002...2,618,033
Ensembl chrNW_004955472:2,604,002...2,618,033 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:14752510) ParkinsonsUK-UCL PMID:14752510 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    response to stimulus 6681
      response to stress 3284
        response to nitrosative stress 9
          cellular response to nitrosative stress 6
            intrinsic apoptotic signaling pathway in response to nitrosative stress 3
              negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 2
              positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 0
              regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 12346
    biological regulation 8880
      regulation of biological process 8618
        regulation of cellular process 8169
          signal transduction 3950
            apoptotic signaling pathway 590
              intrinsic apoptotic signaling pathway 306
                intrinsic apoptotic signaling pathway in response to nitrosative stress 3
                  negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 2
                  positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 0
                  regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway + 2
paths to the root