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Term:Ire1 complex
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Accession:GO:1990332 term browser browse the term
Definition:A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
Comment:An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
Synonyms:exact_synonym: IRE1 dimer
 related_synonym: ERN1 complex

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Ire1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERN1 endoplasmic reticulum to nucleus signaling 1 part_of NAS (PMID:19328063) ParkinsonsUK-UCL PMID:19328063 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,080...64,130,819
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  cellular_component 19373
    protein-containing complex 5904
      endoplasmic reticulum protein-containing complex 131
        Ire1 complex 1
Path 2
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  cellular_component 19373
    cellular anatomical entity 19159
      organelle 14407
        intracellular organelle 13590
          intracellular membrane-bounded organelle 12516
            endoplasmic reticulum 2129
              endoplasmic reticulum subcompartment 1192
                endoplasmic reticulum membrane 1187
                  Ire1 complex 1
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