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Term:Ire1 complex
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Accession:GO:1990332 term browser browse the term
Definition:A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
Comment:An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
Synonyms:exact_synonym: IRE1 dimer
 related_synonym: ERN1 complex

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  cellular_component 19309
    protein-containing complex 5988
      membrane protein complex 1251
        Ire1 complex 0
Path 2
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  cellular_component 19309
    cellular anatomical entity 19051
      organelle 12937
        intracellular organelle 12555
          intracellular membrane-bounded organelle 11151
            endoplasmic reticulum 1780
              endoplasmic reticulum subcompartment 983
                endoplasmic reticulum membrane 974
                  Ire1 complex 0
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