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ONTOLOGY REPORT - ANNOTATIONS

Term:STING complex
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Accession:GO:1990231 term browser browse the term
Definition:A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.
Synonyms:exact_synonym: stimulator of interferon genes complex


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STING complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sting1 stimulator of interferon response cGAMP interactor 1 located_in
part_of		 ISO
IEA		 (PMID:30405246)
GO_REF:0000107
(MGI:6827194|PMID:23910378)		 RGD
Ensembl		 PMID:23910378 PMID:30405246 GO_REF:0000107 MGI:6827194 NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21254
    protein-containing complex 6911
      membrane protein complex 1445
        STING complex 1
Path 2
Term Annotations click to browse term
  cellular_component 21254
    cellular anatomical entity 21098
      organelle 14217
        membrane-bounded organelle 12815
          vesicle 2342
            intracellular vesicle 2092
              cytoplasmic vesicle 2083
                cytoplasmic vesicle membrane 878
                  STING complex 1
paths to the root