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ONTOLOGY REPORT - ANNOTATIONS


Term:exosomal secretion
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Accession:GO:1990182 term browser browse the term
Definition:The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Synonyms:exact_synonym: exosomal secretory pathway;   extracellular vesicular exosome secretion;   multi-vesicular body fusion with plasma membrane;   secretion of exosome
 narrow_synonym: exosomal protein secretion
 never_in_taxon: NCBITaxon:4890 ! Ascomycota



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exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COPS5 COP9 signalosome subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:63,586,062...63,605,213
Ensembl chr 8:65,247,950...65,266,511
JBrowse link
G RAB11A RAB11A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,810,880...44,833,438
Ensembl chr15:63,088,084...63,108,077
JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:34,174,491...34,263,045
Ensembl chr15:52,498,202...52,529,984
JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (MGI:4367682|PMID:18617898) MGI PMID:18617898 MGI:4367682 NCBI chr2B:6,166,296...6,208,338
Ensembl chr2B:119,752,363...119,787,051
JBrowse link
G TSG101 tumor susceptibility 101 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:18,518,110...18,564,814
Ensembl chr11:18,189,868...18,248,149
JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP9A ATPase phospholipid transporting 9A (putative) involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:47,944,444...48,116,500
Ensembl chr20:49,067,994...49,204,871
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in ISO (PMID:26911690) ParkinsonsUK-UCL PMID:26911690 NCBI chr 3:125,784,604...125,873,051 JBrowse link
G VPS4B vacuolar protein sorting 4 homolog B involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:56,749,439...56,782,660
Ensembl chr18:60,060,285...60,095,109
JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,929,613...15,955,631
Ensembl chr 1:16,986,385...17,006,033
Ensembl chr 1:16,986,385...17,006,033
JBrowse link
G CHMP2A charged multivesicular body protein 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:55,564,622...55,568,214
Ensembl chr19:64,377,986...64,381,417
JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:76,143,212...76,161,469
Ensembl chr17:81,844,379...81,862,335
JBrowse link
G MYO5B myosin VB ISO RGD PMID:18984164 RGD:11533643 NCBI chr18:43,207,387...43,575,951
Ensembl chr18:46,555,259...46,786,223
JBrowse link
G PDCD6IP programmed cell death 6 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:33,719,603...33,793,301
Ensembl chr 3:34,016,474...34,093,631
JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chr 3:125,784,604...125,873,051 JBrowse link
G SDC1 syndecan 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:20,187,249...20,211,567
Ensembl chr2A:20,302,589...20,309,848
JBrowse link
G SDC4 syndecan 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:41,656,406...41,679,549
Ensembl chr20:42,746,281...42,769,737
JBrowse link
G SDCBP syndecan binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:54,992,627...55,022,560
Ensembl chr 8:56,643,962...56,673,833
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in ISO PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr16:48,734,664...48,825,241
Ensembl chr16:68,131,905...68,142,871
JBrowse link
G SNF8 SNF8 subunit of ESCRT-II involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:8,595,647...8,609,730
Ensembl chr17:8,578,050...8,794,480
JBrowse link
G STAM signal transducing adaptor molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:17,962,759...18,035,654
Ensembl chr10:18,232,548...18,305,197
JBrowse link
G TSG101 tumor susceptibility 101 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:18,518,110...18,564,814
Ensembl chr11:18,189,868...18,248,149
JBrowse link
G VPS4A vacuolar protein sorting 4 homolog A involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chr16:49,685,827...49,699,542 JBrowse link
G VPS4B vacuolar protein sorting 4 homolog B involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:56,749,439...56,782,660
Ensembl chr18:60,060,285...60,095,109
JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHMP6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chr17:75,415,055...75,423,279
Ensembl chr17:81,144,837...81,151,962
JBrowse link
G LOC100970314 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chr2A:86,559,695...86,619,615
Ensembl chr2A:88,106,242...88,165,104
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15338
    localization 4791
      establishment of localization 4194
        establishment of localization in cell 1908
          establishment of vesicle localization 147
            exosomal secretion 23
              multivesicular body fusion to apical plasma membrane 0
              negative regulation of exosomal secretion 4
              positive regulation of exosomal secretion 15
              regulation of exosomal secretion + 19
Path 2
Term Annotations click to browse term
  biological_process 15338
    localization 4791
      establishment of localization 4194
        transport 4029
          secretion 1042
            secretion by cell 879
              exocytosis 359
                exosomal secretion 23
                  multivesicular body fusion to apical plasma membrane 0
                  negative regulation of exosomal secretion 4
                  positive regulation of exosomal secretion 15
                  regulation of exosomal secretion + 19
paths to the root