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ONTOLOGY REPORT - ANNOTATIONS

Term:GATOR1 complex
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Accession:GO:1990130 term browser browse the term
Definition:A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
Comment:The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
Synonyms:exact_synonym: IML1 complex;   SEACIT complex


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GATOR1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit part_of IBA
ISO		 GO_REF:0000033
(PMID:25263562), (PMID:29590090), (PMID:35338845)		 GO_Central
RGD		 PMID:25263562 PMID:29590090 PMID:35338845 GO_REF:0000033 NCBI chr14:77,732,297...77,862,924
Ensembl chr14:77,732,297...77,862,794 		JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit part_of IBA
ISO		 GO_REF:0000033
(PMID:25263562), (PMID:29590090), (PMID:35338845)		 GO_Central
RGD		 PMID:25263562 PMID:29590090 PMID:35338845 GO_REF:0000033 NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996 		JBrowse link
G Nprl3 NPR3-like, GATOR1 complex subunit part_of IBA
ISO		 GO_REF:0000033
(PMID:25263562), (PMID:29590090), (PMID:35338845)		 GO_Central
RGD		 PMID:25263562 PMID:29590090 PMID:35338845 GO_REF:0000033 NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810 		JBrowse link
G Rraga Ras-related GTP binding A part_of
located_in		 IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:25936802)		 Ensembl
UniProt
RGD		 PMID:25936802 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510 		JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex located_in ISO (PMID:28199306), (PMID:28199315) RGD PMID:28199306 PMID:28199315 NCBI chr 5:131,897,250...131,943,953
Ensembl chr 5:131,897,275...131,943,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20811
    protein-containing complex 6431
      GATOR1 complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20811
    protein-containing complex 6431
      Seh1-associated complex 14
        GATOR1 complex 5
paths to the root