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ONTOLOGY REPORT - ANNOTATIONS


Term:GATOR1 complex
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Accession:GO:1990130 term browser browse the term
Definition:A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
Comment:The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
Synonyms:exact_synonym: IML1 complex;   SEACIT complex



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GATOR1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmt2 base methyltransferase of 25S rRNA 2 homolog colocalizes_with
part_of
ISO
IEA
(PMID:29123071)
GO_REF:0000107
RGD
Ensembl
PMID:29123071 GO_REF:0000107 NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit part_of
located_in
IBA
ISO
PMID:21873635
(PMID:23723238)
(PMID:25263562)
RGD PMID:23723238 PMID:25263562 PMID:21873635 RGD:13792537 NCBI chr14:77,732,297...77,862,924
Ensembl chr14:77,732,297...77,862,794
JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit part_of
located_in
ISO
IBA
(PMID:23723238)
PMID:21873635
(PMID:25263562)
RGD PMID:23723238 PMID:25263562 PMID:21873635 RGD:13792537 NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
JBrowse link
G Nprl3 NPR3-like, GATOR1 complex subunit part_of
located_in
IBA
ISO
PMID:21873635
(PMID:23723238)
(PMID:25263562)
RGD PMID:23723238 PMID:25263562 PMID:21873635 RGD:13792537 NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810
JBrowse link
G Rraga Ras-related GTP binding A colocalizes_with ISO
ISS
(PMID:25936802)
GO_REF:0000024
RGD
UniProt
PMID:25936802 GO_REF:0000024 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex colocalizes_with
part_of
ISO
IEA
(PMID:28199306), (PMID:28199315)
GO_REF:0000107
RGD
Ensembl
PMID:28199306 PMID:28199315 GO_REF:0000107 NCBI chr 5:131,897,250...131,943,953
Ensembl chr 5:131,897,275...131,943,904
JBrowse link

Term paths to the root
Path 1
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  cellular_component 19309
    protein-containing complex 5988
      GATOR1 complex 6
Path 2
Term Annotations click to browse term
  cellular_component 19309
    protein-containing complex 5988
      Seh1-associated complex 15
        GATOR1 complex 6
paths to the root