GATOR1 complex - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	GATOR1 complex	go back to main search page
Accession:	GO:1990130	browse the term
Definition:	A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
Comment:	The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
Synonyms:	exact_synonym:	IML1 complex; SEACIT complex

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Rat (6) Mouse (6) Human (6) Chinchilla (6) Bonobo (6) Dog (6) Squirrel (6) Pig (7) Green Monkey (8) Naked Mole-rat (6) All
Genes (6)

GATOR1 complex

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bmt2

base methyltransferase of 25S rRNA 2 homolog

colocalizes_with
part_of

ISO
IEA

(PMID:29123071)
GO_REF:0000107

RGD
Ensembl

PMID:29123071

GO_REF:0000107

NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539

Depdc5

DEP domain containing 5, GATOR1 subcomplex subunit

part_of
located_in

IBA
ISO

PMID:21873635
(PMID:23723238)
(PMID:25263562)

RGD

PMID:23723238 PMID:25263562 PMID:21873635

RGD:13792537

NCBI chr14:77,732,297...77,862,924
Ensembl chr14:77,732,297...77,862,794

Nprl2

NPR2-like, GATOR1 complex subunit

part_of
located_in

ISO
IBA

(PMID:23723238)
PMID:21873635
(PMID:25263562)

RGD

PMID:23723238 PMID:25263562 PMID:21873635

RGD:13792537

NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996

Nprl3

NPR3-like, GATOR1 complex subunit

part_of
located_in

IBA
ISO

PMID:21873635
(PMID:23723238)
(PMID:25263562)

RGD

PMID:23723238 PMID:25263562 PMID:21873635

RGD:13792537

NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810

Rraga

Ras-related GTP binding A

colocalizes_with

ISO
ISS

(PMID:25936802)
GO_REF:0000024

RGD
UniProt

PMID:25936802

GO_REF:0000024

NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510

Szt2

SZT2 subunit of KICSTOR complex

colocalizes_with
part_of

ISO
IEA

(PMID:28199306), (PMID:28199315)
GO_REF:0000107

RGD
Ensembl

PMID:28199306 PMID:28199315

GO_REF:0000107

NCBI chr 5:131,897,250...131,943,953
Ensembl chr 5:131,897,275...131,943,904

Term paths to the root

Path 1
Term	Annotations
cellular_component	19309
protein-containing complex	5988
GATOR1 complex	6
Path 2
Term	Annotations
cellular_component	19309
protein-containing complex	5988
Seh1-associated complex	15
GATOR1 complex	6

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ONTOLOGY REPORT - ANNOTATIONS