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Term: GATOR1 complex
Accession: GO:1990130
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Definition: A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
Comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
Synonyms: exact_synonym: IML1 complex; SEACIT complex
G
Bmt2
base methyltransferase of 25S rRNA 2 homolog
colocalizes_with part_of
ISO IEA
(PMID:29123071) GO_REF:0000107
RGD Ensembl
PMID:29123071
GO_REF:0000107
NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539
G
Depdc5
DEP domain containing 5, GATOR1 subcomplex subunit
part_of located_in
IBA ISO
PMID:21873635 (PMID:23723238) (PMID:25263562)
RGD
PMID:23723238 PMID:25263562 PMID:21873635
RGD:13792537
NCBI chr14:77,732,297...77,862,924
Ensembl chr14:77,732,297...77,862,794
G
Nprl2
NPR2-like, GATOR1 complex subunit
part_of located_in
ISO IBA
(PMID:23723238) PMID:21873635 (PMID:25263562)
RGD
PMID:23723238 PMID:25263562 PMID:21873635
RGD:13792537
NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
G
Nprl3
NPR3-like, GATOR1 complex subunit
part_of located_in
IBA ISO
PMID:21873635 (PMID:23723238) (PMID:25263562)
RGD
PMID:23723238 PMID:25263562 PMID:21873635
RGD:13792537
NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810
G
Rraga
Ras-related GTP binding A
colocalizes_with
ISO ISS
(PMID:25936802) GO_REF:0000024
RGD UniProt
PMID:25936802
GO_REF:0000024
NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
G
Szt2
SZT2 subunit of KICSTOR complex
colocalizes_with part_of
ISO IEA
(PMID:28199306), (PMID:28199315) GO_REF:0000107
RGD Ensembl
PMID:28199306 PMID:28199315
GO_REF:0000107
NCBI chr 5:131,897,250...131,943,953
Ensembl chr 5:131,897,275...131,943,904
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