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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid fibril formation
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Accession:GO:1990000 term browser browse the term
Definition:The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: amyloid fibril assembly;   amyloid structure assembly;   amyloid structure formation


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amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997 		JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107
G CAMP cathelicidin antimicrobial peptide involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:40,790,823...40,792,781
Ensembl chr20:40,790,811...40,792,794 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (PMID:12630860) DisProt PMID:12630860 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G CDSN corneodesmosin involved_in ISO (PMID:20448140) DisProt PMID:20448140 NCBI chr12:819,488...824,015
Ensembl chr12:820,467...823,986 		JBrowse link
G CSTB cystatin B involved_in IEA Ensembl GO_REF:0000107
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (PMID:18346205) BHF-UCL PMID:18346205 NCBI chr24:19,618,581...19,643,685
Ensembl chr24:19,618,558...19,643,046 		JBrowse link
G FUS FUS RNA binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,059,904...17,071,227
Ensembl chr 6:17,060,061...17,071,178 		JBrowse link
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:74,248,227...74,268,129
Ensembl chr11:74,233,457...74,268,129 		JBrowse link
G IAPP islet amyloid polypeptide involved_in ISO (PMID:22944668) UniProt PMID:22944668 NCBI chr27:26,295,481...26,299,967
Ensembl chr27:26,295,481...26,299,967 		JBrowse link
G MAPT microtubule associated protein tau involved_in ISO (PMID:7929085)
(PMID:14769047)
(PMID:14769047), (PMID:7929085)		 CAFA
DisProt		 PMID:7929085 PMID:14769047 NCBI chr 9:9,572,174...9,674,082
Ensembl chr 9:9,570,557...9,674,349 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596 		JBrowse link
G NUP153 nucleoporin 153 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:16,517,992...16,598,472
Ensembl chr35:16,519,109...16,589,537 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in ISO (PMID:22817896) UniProt PMID:22817896 NCBI chr 8:4,304,167...4,309,514
Ensembl chr 8:4,305,250...4,309,325 		JBrowse link
G SERF1A small EDRK-rich factor 1A involved_in ISO (PMID:22854022), (PMID:31034892) UniProt PMID:22854022 PMID:31034892 NCBI chr 2:54,647,131...54,654,434
Ensembl chr 2:54,647,131...54,654,118 		JBrowse link
G SLC35E3 solute carrier family 35 member E3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,892,999...10,908,142 JBrowse link
G SNCA synuclein alpha involved_in ISO (PMID:8901511) DisProt PMID:8901511 NCBI chr32:12,915,871...13,079,338
Ensembl chr32:12,916,215...13,060,383 		JBrowse link
G TARDBP TAR DNA binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,987,752...84,998,136
Ensembl chr 2:84,989,952...84,998,593 		JBrowse link
G VHL von Hippel-Lindau tumor suppressor involved_in ISO (PMID:34431623) DisProt PMID:34431623 NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323 		JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G CLU clusterin involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G CRYAB crystallin alpha B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,181,836...21,185,164
Ensembl chr 5:21,179,936...21,360,132 		JBrowse link
G HSPG2 heparan sulfate proteoglycan 2 involved_in ISO (PMID:21126803) ARUK-UCL PMID:21126803 NCBI chr 2:77,263,534...77,366,558
Ensembl chr 2:77,301,858...77,367,724 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:50,115,175...50,152,443
Ensembl chr20:50,048,736...50,152,355 		JBrowse link
G MIR31 microRNA mir-31 acts_upstream_of ISO (PMID:32069773) ARUK-UCL PMID:32069773 NCBI chr11:40,904,438...40,904,496
Ensembl chr11:40,904,437...40,904,503 		JBrowse link
G PFDN1 prefoldin subunit 1 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr 2:35,454,139...35,519,818
Ensembl chr 2:35,454,404...35,519,725 		JBrowse link
G PFDN2 prefoldin subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,355,622...21,367,623
Ensembl chr38:21,355,678...21,367,619 		JBrowse link
G PFDN4 prefoldin subunit 4 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr24:39,904,803...39,915,173
Ensembl chr24:39,910,458...39,915,164 		JBrowse link
G PFDN5 prefoldin subunit 5 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr27:1,906,133...1,909,613
Ensembl chr27:1,906,133...1,909,613 		JBrowse link
G PFDN6 prefoldin subunit 6 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr12:2,729,562...2,730,858
Ensembl chr12:2,729,562...2,737,163 		JBrowse link
G VBP1 VHL binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:123,210,965...123,231,847
Ensembl chr  X:123,203,722...123,231,091 		JBrowse link
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G PSEN1 presenilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
G USP8 ubiquitin specific peptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:16,341,970...16,408,246
Ensembl chr30:16,342,009...16,408,012 		JBrowse link
regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:25207746) ARUK-UCL PMID:25207746 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:11140685) ARUK-UCL PMID:11140685 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      primary metabolic process 9574
        protein metabolic process 4325
          amyloid fibril formation 37
            negative regulation of amyloid fibril formation 12
            positive regulation of amyloid fibril formation 3
            regulation of amyloid fibril formation + 16
Path 2
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      organic substance metabolic process 10554
        macromolecule metabolic process 8924
          protein metabolic process 4325
            amyloid fibril formation 37
              negative regulation of amyloid fibril formation 12
              positive regulation of amyloid fibril formation 3
              regulation of amyloid fibril formation + 16
paths to the root