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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid fibril formation
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Accession:GO:1990000 term browser browse the term
Definition:The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: amyloid fibril assembly;   amyloid structure assembly;   amyloid structure formation


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amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:25620700) ParkinsonsUK-UCL PMID:25620700 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G B2m beta-2-microglobulin ISO (PMID:28468825) ARUK-UCL PMID:28468825 NCBI chrNW_004955416:11,205,503...11,211,325 JBrowse link
G Cd36 CD36 molecule ISO (MGI:MGI:5546292|PMID:23812099) UniProtKB PMID:23812099 MGI:MGI:5546292 NCBI chrNW_004955410:5,003,720...5,120,903 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:18346205) BHF-UCL PMID:18346205 NCBI chrNW_004955596:580,106...606,210 JBrowse link
G Gsn gelsolin ISO (PMID:19904968), (PMID:24601799) UniProtKB PMID:19904968, PMID:24601799 NCBI chrNW_004955419:6,682,202...6,733,361 JBrowse link
G Iapp islet amyloid polypeptide ISO (PMID:22944668) UniProt PMID:22944668 NCBI chrNW_004955413:16,834,940...16,841,071 JBrowse link
G Mapt microtubule associated protein tau ISO (PMID:7929085) CAFA PMID:7929085 NCBI chrNW_004955478:10,222,439...10,271,439 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:12630860) CAFA PMID:12630860 NCBI chrNW_004955458:15,264,028...15,287,290 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (PMID:22817896) UniProtKB PMID:22817896 NCBI chrNW_004955465:10,127,907...10,167,895 JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 ISO (PMID:22817896) UniProtKB PMID:22817896 NCBI chrNW_004955409:35,961,604...35,965,477 JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO (MGI:MGI:3621689|PMID:14741101) UniProt PMID:14741101 MGI:MGI:3621689 NCBI chrNW_004955555:1,998,170...2,002,003 JBrowse link
G Clu clusterin ISO (PMID:22179788)
(MGI:MGI:3621689|PMID:14741101)
ARUK-UCL
UniProt
PMID:14741101, PMID:22179788 MGI:MGI:3621689 NCBI chrNW_004955403:50,160,598...50,175,876 JBrowse link
G Cryab crystallin alpha B ISO (PMID:23106396) ARUK-UCL PMID:23106396 NCBI chrNW_004955412:13,626,018...13,629,495 JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 ISO (PMID:21126803) ARUK-UCL PMID:21126803 NCBI chrNW_004955452:2,056,428...2,141,937 JBrowse link
G Ldlr low density lipoprotein receptor ISO (MGI:MGI:4415751|PMID:20005821) ARUK-UCL PMID:20005821 MGI:MGI:4415751 NCBI chrNW_004955495:2,114,702...2,135,584 JBrowse link
positive regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:19660551) ARUK-UCL PMID:19660551 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G Psen1 presenilin 1 ISO (PMID:11880515) ARUK-UCL PMID:11880515 NCBI chrNW_004955523:2,128,529...2,210,737 JBrowse link
regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO (PMID:25207746) ARUK-UCL PMID:25207746 NCBI chrNW_004955555:1,998,170...2,002,003 JBrowse link
G App amyloid beta precursor protein ISO (PMID:11140685) ARUK-UCL PMID:11140685 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO (MGI:MGI:4437154|PMID:20164328) ARUK-UCL PMID:20164328 MGI:MGI:4437154 NCBI chrNW_004955416:30,687,518...30,798,700 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11862
    metabolic process 7593
      primary metabolic process 6730
        protein metabolic process 3840
          amyloid fibril formation 17
            negative regulation of amyloid fibril formation 5
            positive regulation of amyloid fibril formation 2
            regulation of amyloid fibril formation + 8
Path 2
Term Annotations click to browse term
  biological_process 11862
    metabolic process 7593
      organic substance metabolic process 7299
        macromolecule metabolic process 6337
          protein metabolic process 3840
            amyloid fibril formation 17
              negative regulation of amyloid fibril formation 5
              positive regulation of amyloid fibril formation 2
              regulation of amyloid fibril formation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.