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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid fibril formation
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Accession:GO:1990000 term browser browse the term
Definition:The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: amyloid fibril assembly;   amyloid structure assembly;   amyloid structure formation


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amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:25620700) RGD PMID:25620700 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G B2m beta-2 microglobulin ISO (PMID:28468825) RGD PMID:28468825 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Cd36 CD36 molecule ISO
ISS
(MGI:MGI:5546292|PMID:23812099)
GO_REF:0000024
RGD
UniProt
PMID:23812099 GO_REF:0000024, MGI:MGI:5546292 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (PMID:12630860) RGD PMID:12630860 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:18346205) RGD PMID:18346205 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Gsn gelsolin ISO (PMID:19904968), (PMID:24601799) RGD PMID:19904968, PMID:24601799 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Iapp islet amyloid polypeptide ISO (PMID:22944668) RGD PMID:22944668 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Mapt microtubule-associated protein tau ISO
IEA
(PMID:7929085)
GO_REF:0000107
RGD
Ensembl
PMID:7929085 GO_REF:0000107 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:12630860) RGD PMID:12630860 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO
ISS
(PMID:22817896)
GO_REF:0000024
RGD
UniProt
PMID:22817896 GO_REF:0000024 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ISO
ISS
(PMID:22817896)
GO_REF:0000024
RGD
UniProt
PMID:22817896 GO_REF:0000024 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Serf1 small EDRK-rich factor 1 ISO (PMID:22854022), (PMID:31034892) RGD PMID:22854022, PMID:31034892 NCBI chr 2:30,345,861...30,352,114
Ensembl chr 2:30,346,069...30,352,099
JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
ISS
(MGI:MGI:3621689|PMID:14741101)
GO_REF:0000024
RGD
UniProt
PMID:14741101 GO_REF:0000024, MGI:MGI:3621689 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Clu clusterin ISO
ISS
IEA
(PMID:22179788)
GO_REF:0000024
(MGI:MGI:3621689|PMID:14741101)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14741101, PMID:22179788 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3621689 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cryab crystallin, alpha B ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:155,812,096...155,913,751 JBrowse link
G Ldlr low density lipoprotein receptor IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107, MGI:MGI:4415751 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
positive regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:19660551) RGD PMID:19660551 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Psen1 presenilin 1 ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
(PMID:25207746)
Ensembl
RGD
PMID:25207746 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107, MGI:MGI:4437154 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      primary metabolic process 10901
        protein metabolic process 6214
          amyloid fibril formation 19
            negative regulation of amyloid fibril formation 5
            positive regulation of amyloid fibril formation 2
            regulation of amyloid fibril formation + 8
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          protein metabolic process 6214
            amyloid fibril formation 19
              negative regulation of amyloid fibril formation 5
              positive regulation of amyloid fibril formation 2
              regulation of amyloid fibril formation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.