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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid fibril formation
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Accession:GO:1990000 term browser browse the term
Definition:The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: amyloid fibril assembly;   amyloid structure assembly;   amyloid structure formation


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amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO (PMID:25620700) RGD PMID:25620700 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G B2m beta-2 microglobulin involved_in ISO (PMID:28468825) RGD PMID:28468825 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cd36 CD36 molecule involved_in ISS
ISO
GO_REF:0000024
(MGI:5546292|PMID:23812099)
UniProt
RGD
PMID:23812099 GO_REF:0000024 MGI:5546292 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:12630860) RGD PMID:12630860 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:18346205) RGD PMID:18346205 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Gsn gelsolin involved_in ISO (PMID:19904968), (PMID:24601799) RGD PMID:19904968 PMID:24601799 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Iapp islet amyloid polypeptide involved_in ISO (PMID:22944668) RGD PMID:22944668 NCBI chr 4:175,237,013...175,244,373
Ensembl chr 4:175,237,115...175,242,920
JBrowse link
G Mapt microtubule-associated protein tau involved_in IEA
ISO
GO_REF:0000107
(PMID:7929085)
Ensembl
RGD
PMID:7929085 GO_REF:0000107 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:12630860) RGD PMID:12630860 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO
ISS
(PMID:22817896)
GO_REF:0000024
RGD
UniProt
PMID:22817896 GO_REF:0000024 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS
(PMID:22817896)
GO_REF:0000024
RGD
UniProt
PMID:22817896 GO_REF:0000024 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Serf1 small EDRK-rich factor 1 involved_in ISO (PMID:22854022), (PMID:31034892) RGD PMID:22854022 PMID:31034892 NCBI chr 2:31,475,777...31,482,030
Ensembl chr 2:31,475,703...31,482,032
JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISS
ISO
GO_REF:0000024
(MGI:3621689|PMID:14741101)
UniProt
RGD
PMID:14741101 GO_REF:0000024 MGI:3621689 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA
(PMID:22179788)
(MGI:3621689|PMID:14741101)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14741101 PMID:22179788 GO_REF:0000024 GO_REF:0000107 MGI:3621689 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cryab crystallin, alpha B involved_in ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 involved_in ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:149,677,437...149,778,594 JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Pfdn1 prefoldin subunit 1 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064
JBrowse link
G Pfdn2 prefoldin subunit 2 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504
JBrowse link
G Pfdn4 prefoldin subunit 4 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 3:159,303,064...159,311,221
Ensembl chr 3:159,303,071...159,311,219
JBrowse link
G Pfdn5 prefoldin subunit 5 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
JBrowse link
G Pfdn6 prefoldin subunit 6 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6313424|PMID:30617257) RGD PMID:30617257 MGI:6313424 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Vbp1 VHL binding protein 1 involved_in ISO (PMID:23614719) RGD PMID:23614719
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO (PMID:19660551) RGD PMID:19660551 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Psen1 presenilin 1 involved_in ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IEA
ISO
GO_REF:0000107
(PMID:25207746)
Ensembl
RGD
PMID:25207746 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107 MGI:4437154 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      primary metabolic process 10530
        protein metabolic process 5891
          amyloid fibril formation 26
            negative regulation of amyloid fibril formation 12
            positive regulation of amyloid fibril formation 2
            regulation of amyloid fibril formation + 15
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      organic substance metabolic process 11337
        macromolecule metabolic process 9793
          protein metabolic process 5891
            amyloid fibril formation 26
              negative regulation of amyloid fibril formation 12
              positive regulation of amyloid fibril formation 2
              regulation of amyloid fibril formation + 15
paths to the root