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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of amyloid fibril formation
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Accession:GO:1905908 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: up regulation of amyloid fibril formation;   upregulation of amyloid fibril formation
 narrow_synonym: activation of amyloid fibril formation
 related_synonym: activation of amyloid fibril assembly;   activation of amyloid structure assembly;   activation of amyloid structure formation;   positive regulation of amyloid fibril assembly;   positive regulation of amyloid structure assembly;   positive regulation of amyloid structure formation;   up regulation of amyloid fibril assembly;   up regulation of amyloid structure assembly;   up regulation of amyloid structure formation;   upregulation of amyloid fibril assembly;   upregulation of amyloid structure assembly;   upregulation of amyloid structure formation

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positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
G Psen1 presenilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:12,463,189...12,524,148
Ensembl chrNW_004936471:12,463,120...12,520,674 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      positive regulation of metabolic process 3466
        positive regulation of macromolecule metabolic process 3153
          positive regulation of protein metabolic process 1018
            positive regulation of amyloid fibril formation 3
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological process 10818
        regulation of metabolic process 5604
          positive regulation of metabolic process 3466
            positive regulation of macromolecule metabolic process 3153
              positive regulation of protein metabolic process 1018
                positive regulation of amyloid fibril formation 3
paths to the root