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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of amyloid fibril formation
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Accession:GO:1905908 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: up regulation of amyloid fibril formation;   upregulation of amyloid fibril formation
 narrow_synonym: activation of amyloid fibril formation
 related_synonym: activation of amyloid fibril assembly;   activation of amyloid structure assembly;   activation of amyloid structure formation;   positive regulation of amyloid fibril assembly;   positive regulation of amyloid structure assembly;   positive regulation of amyloid structure formation;   up regulation of amyloid fibril assembly;   up regulation of amyloid structure assembly;   up regulation of amyloid structure formation;   upregulation of amyloid fibril assembly;   upregulation of amyloid structure assembly;   upregulation of amyloid structure formation


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positive regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:19660551) ARUK-UCL PMID:19660551 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
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G Psen1 presenilin 1 ISO (PMID:11880515) ARUK-UCL PMID:11880515 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11884
    metabolic process 7607
      positive regulation of metabolic process 3314
        positive regulation of macromolecule metabolic process 3074
          positive regulation of protein metabolic process 1477
            positive regulation of amyloid fibril formation 2
Path 2
Term Annotations click to browse term
  biological_process 11884
    biological regulation 8707
      regulation of biological process 8252
        regulation of metabolic process 5032
          positive regulation of metabolic process 3314
            positive regulation of macromolecule metabolic process 3074
              positive regulation of protein metabolic process 1477
                positive regulation of amyloid fibril formation 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.