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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of amyloid fibril formation
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Accession:GO:1905907 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: down regulation of amyloid fibril formation;   downregulation of amyloid fibril formation
 narrow_synonym: inhibition of amyloid fibril formation
 related_synonym: down regulation of amyloid fibril assembly;   down regulation of amyloid structure assembly;   down regulation of amyloid structure formation;   downregulation of amyloid fibril assembly;   downregulation of amyloid structure assembly;   downregulation of amyloid structure formation;   inhibition of amyloid fibril assembly;   inhibition of amyloid structure assembly;   inhibition of amyloid structure formation;   negative regulation of amyloid fibril assembly;   negative regulation of amyloid structure assembly;   negative regulation of amyloid structure formation


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negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G CLU clusterin involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G CRYAB crystallin alpha B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,181,836...21,185,164
Ensembl chr 5:21,179,936...21,360,132 		JBrowse link
G HSPG2 heparan sulfate proteoglycan 2 involved_in ISO (PMID:21126803) ARUK-UCL PMID:21126803 NCBI chr 2:77,263,534...77,366,558
Ensembl chr 2:77,301,858...77,367,724 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:50,115,175...50,152,443
Ensembl chr20:50,048,736...50,152,355 		JBrowse link
G MIR31 microRNA mir-31 acts_upstream_of ISO (PMID:32069773) ARUK-UCL PMID:32069773 NCBI chr11:40,904,438...40,904,496
Ensembl chr11:40,904,437...40,904,503 		JBrowse link
G PFDN1 prefoldin subunit 1 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr 2:35,454,139...35,519,818
Ensembl chr 2:35,454,404...35,519,725 		JBrowse link
G PFDN2 prefoldin subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,355,622...21,367,623
Ensembl chr38:21,355,678...21,367,619 		JBrowse link
G PFDN4 prefoldin subunit 4 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr24:39,904,803...39,915,173
Ensembl chr24:39,910,458...39,915,164 		JBrowse link
G PFDN5 prefoldin subunit 5 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr27:1,906,133...1,909,613
Ensembl chr27:1,906,133...1,909,613 		JBrowse link
G PFDN6 prefoldin subunit 6 involved_in ISO (PMID:23614719) FlyBase PMID:23614719 NCBI chr12:2,729,562...2,730,858
Ensembl chr12:2,729,562...2,737,163 		JBrowse link
G VBP1 VHL binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:123,210,965...123,231,847
Ensembl chr  X:123,203,722...123,231,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      negative regulation of metabolic process 3119
        negative regulation of macromolecule metabolic process 2889
          negative regulation of protein metabolic process 721
            negative regulation of amyloid fibril formation 12
Path 2
Term Annotations click to browse term
  biological_process 17917
    biological regulation 12438
      regulation of biological process 12078
        regulation of metabolic process 6412
          negative regulation of metabolic process 3119
            negative regulation of macromolecule metabolic process 2889
              negative regulation of protein metabolic process 721
                negative regulation of amyloid fibril formation 12
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