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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid fibril formation
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Accession:GO:1905907 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: down regulation of amyloid fibril formation;   downregulation of amyloid fibril formation
 narrow_synonym: inhibition of amyloid fibril formation
 related_synonym: down regulation of amyloid fibril assembly;   down regulation of amyloid structure assembly;   down regulation of amyloid structure formation;   downregulation of amyloid fibril assembly;   downregulation of amyloid structure assembly;   downregulation of amyloid structure formation;   inhibition of amyloid fibril assembly;   inhibition of amyloid structure assembly;   inhibition of amyloid structure formation;   negative regulation of amyloid fibril assembly;   negative regulation of amyloid structure assembly;   negative regulation of amyloid structure formation


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negative regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO (MGI:MGI:3621689|PMID:14741101) UniProt PMID:14741101 MGI:MGI:3621689 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Clu clusterin ISO (PMID:22179788)
(MGI:MGI:3621689|PMID:14741101)
ARUK-UCL
UniProt
PMID:14741101, PMID:22179788 MGI:MGI:3621689 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
JBrowse link
G Cryab crystallin alpha B ISO (PMID:23106396) ARUK-UCL PMID:23106396 NCBI chrNW_004955412:13,626,018...13,629,495
Ensembl chrNW_004955412:13,625,363...13,640,426
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 ISO (PMID:21126803) ARUK-UCL PMID:21126803 NCBI chrNW_004955452:2,056,428...2,141,937
Ensembl chrNW_004955452:2,057,326...2,120,280
JBrowse link
G Ldlr low density lipoprotein receptor ISO (MGI:MGI:4415751|PMID:20005821) ARUK-UCL PMID:20005821 MGI:MGI:4415751 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7610
      negative regulation of metabolic process 2525
        negative regulation of macromolecule metabolic process 2278
          negative regulation of protein metabolic process 888
            negative regulation of amyloid fibril formation 5
Path 2
Term Annotations click to browse term
  biological_process 11892
    biological regulation 8722
      regulation of biological process 8267
        regulation of metabolic process 5030
          negative regulation of metabolic process 2525
            negative regulation of macromolecule metabolic process 2278
              negative regulation of protein metabolic process 888
                negative regulation of amyloid fibril formation 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.