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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid fibril formation
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Accession:GO:1905906 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: regulation of amyloid fibril assembly;   regulation of amyloid structure assembly;   regulation of amyloid structure formation


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regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO (PMID:25207746) ARUK-UCL PMID:25207746 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G App amyloid beta precursor protein ISO (PMID:11140685) ARUK-UCL PMID:11140685 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO (MGI:MGI:4437154|PMID:20164328) ARUK-UCL PMID:20164328 MGI:MGI:4437154 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700
JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO (MGI:MGI:3621689|PMID:14741101) UniProt PMID:14741101 MGI:MGI:3621689 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Clu clusterin ISO (PMID:22179788)
(MGI:MGI:3621689|PMID:14741101)
ARUK-UCL
UniProt
PMID:14741101, PMID:22179788 MGI:MGI:3621689 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
JBrowse link
G Cryab crystallin alpha B ISO (PMID:23106396) ARUK-UCL PMID:23106396 NCBI chrNW_004955412:13,626,018...13,629,495
Ensembl chrNW_004955412:13,625,363...13,640,426
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 ISO (PMID:21126803) ARUK-UCL PMID:21126803 NCBI chrNW_004955452:2,056,428...2,141,937
Ensembl chrNW_004955452:2,057,326...2,120,280
JBrowse link
G Ldlr low density lipoprotein receptor ISO (MGI:MGI:4415751|PMID:20005821) ARUK-UCL PMID:20005821 MGI:MGI:4415751 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056
JBrowse link
positive regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:19660551) ARUK-UCL PMID:19660551 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Psen1 presenilin 1 ISO (PMID:11880515) ARUK-UCL PMID:11880515 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11884
    metabolic process 7607
      primary metabolic process 6745
        protein metabolic process 3849
          regulation of protein metabolic process 2277
            regulation of amyloid fibril formation 8
              negative regulation of amyloid fibril formation 5
              positive regulation of amyloid fibril formation 2
Path 2
Term Annotations click to browse term
  biological_process 11884
    metabolic process 7607
      organic substance metabolic process 7318
        organonitrogen compound metabolic process 4450
          protein metabolic process 3849
            amyloid fibril formation 17
              regulation of amyloid fibril formation 8
                negative regulation of amyloid fibril formation 5
                positive regulation of amyloid fibril formation 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.