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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of chromosome separation
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Accession:GO:1905819 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation.
Synonyms:exact_synonym: down regulation of chromosome separation;   downregulation of chromosome separation
 narrow_synonym: down regulation of rDNA separation;   downregulation of rDNA separation;   inhibition of chromosome separation;   inhibition of rDNA separation;   negative regulation of rDNA separation
 related_synonym: down regulation of chromatid release;   downregulation of chromatid release;   inhibition of chromatid release;   negative regulation of chromatid release


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IMP (PMID:22581055) CAFA PMID:22581055 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in IDA (PMID:19010891) UniProt PMID:19010891 NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243
JBrowse link
G MAD2L1BP MAD2L1 binding protein involved_in IMP (PMID:18022368) UniProt PMID:18022368 NCBI chr 6:43,629,540...43,640,941
Ensembl chr 6:43,629,540...43,640,941
JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in IDA (PMID:24374861) UniProt PMID:24374861 NCBI chr10:133,347,373...133,352,683
Ensembl chr10:133,347,368...133,352,683
JBrowse link
meiotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TTK TTK protein kinase involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5049806|PMID:21558374)
GO_Central
MGI
PMID:21558374 PMID:21873635 MGI:5049806 NCBI chr 6:80,004,147...80,042,651
Ensembl chr 6:80,003,887...80,042,527
JBrowse link
meiotic spindle checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHFR checkpoint with forkhead and ring finger domains involved_in IMP (PMID:10935642) UniProt PMID:10935642 NCBI chr12:132,832,356...132,887,618
Ensembl chr12:132,822,187...132,956,304
JBrowse link
mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway acts_upstream_of_or_within IMP (PMID:17227893) MGI PMID:17227893 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G ATM ATM serine/threonine kinase involved_in IMP (PMID:11943150) UniProt PMID:11943150 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,223,044...108,369,102
JBrowse link
G AURKB aurora kinase B involved_in IEA InterPro GO_REF:0000002 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 involved_in IMP (PMID:12805209) UniProt PMID:12805209 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase involved_in IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B involved_in IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123
JBrowse link
G BUB1B-PAK6 BUB1B-PAK6 readthrough involved_in IEA InterPro GO_REF:0000002 NCBI chr15:40,217,428...40,277,487
Ensembl chr15:40,218,500...40,264,890
Ensembl chr15:40,218,500...40,264,890
JBrowse link
G BUB3 BUB3 mitotic checkpoint protein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:123,154,402...123,170,467
Ensembl chr10:123,154,402...123,170,467
JBrowse link
G CENPE centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G CENPF centromere protein F involved_in NAS (PMID:12974617) UniProt PMID:12974617 NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,195...214,664,571
JBrowse link
G IK IK cytokine involved_in IMP (PMID:22351768) UniProt PMID:22351768 NCBI chr 5:140,647,818...140,662,480
Ensembl chr 5:140,647,058...140,662,480
JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member acts_upstream_of_or_within ISO (MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:3844372 NCBI chr 6:73,362,658...73,364,171
Ensembl chr 6:73,362,658...73,364,171
JBrowse link
G KLHL22 kelch like family member 22 involved_in IMP
IBA
(PMID:23455478)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635 PMID:23455478 NCBI chr22:20,441,519...20,497,305
Ensembl chr22:20,441,519...20,495,844
JBrowse link
G KNTC1 kinetochore associated 1 involved_in IDA (PMID:11146660) UniProt PMID:11146660 NCBI chr12:122,527,106...122,626,409
Ensembl chr12:122,527,246...122,626,396
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in NAS
IBA
IEA
IDA
(PMID:9546394)
(PMID:21873635)
(PMID:18981471)
UniProt
GO_Central
InterPro
PMID:9546394 PMID:18981471 PMID:21873635 GO_REF:0000002 NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within
IDA
ISO
IBA
(PMID:18981471)
(MGI:1930685|PMID:11201745)
(PMID:21873635)
UniProt
MGI
GO_Central
PMID:11201745 PMID:18981471 PMID:21873635 MGI:1930685 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in TAS (PMID:10366450) PINC PMID:10366450 NCBI chr 1:11,674,480...11,691,559
Ensembl chr 1:11,674,480...11,691,650
JBrowse link
G PLK1 polo like kinase 1 involved_in IMP (PMID:23455478) UniProt PMID:23455478 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367
JBrowse link
G PSMG2 proteasome assembly chaperone 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2388532|PMID:12147697) Ensembl
MGI
PMID:12147697 GO_REF:0000107 MGI:2388532 NCBI chr18:12,658,738...12,725,740
Ensembl chr18:12,658,043...12,725,740
JBrowse link
G SPDL1 spindle apparatus coiled-coil protein 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:169,583,661...169,604,778
Ensembl chr 5:169,583,636...169,604,778
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor involved_in ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
InterPro
PMID:21873635 GO_REF:0000002 GO_REF:0000024 NCBI chr17:58,556,678...58,692,045
Ensembl chr17:58,556,678...58,692,055
JBrowse link
G TPR translocated promoter region, nuclear basket protein involved_in IMP (PMID:20133940) UniProt PMID:20133940 NCBI chr 1:186,311,652...186,375,253
Ensembl chr 1:186,311,652...186,375,693
JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 involved_in IMP (PMID:28553959) UniProt PMID:28553959 NCBI chr 5:892,884...919,348
Ensembl chr 5:892,884...919,357
JBrowse link
G TTK TTK protein kinase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:80,004,147...80,042,651
Ensembl chr 6:80,003,887...80,042,527
JBrowse link
G ZNF207 zinc finger protein 207 involved_in IMP
IBA
(PMID:24462186), (PMID:24462187)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635 PMID:24462186 PMID:24462187 NCBI chr17:32,350,157...32,381,885
Ensembl chr17:32,350,132...32,381,885
JBrowse link
G ZW10 zw10 kinetochore protein involved_in IBA
IDA
(PMID:21873635)
(PMID:11146660)
GO_Central
UniProt
PMID:11146660 PMID:21873635 NCBI chr11:113,733,183...113,773,699
Ensembl chr11:113,733,187...113,773,735
JBrowse link
G ZWILCH zwilch kinetochore protein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:66,505,126...66,550,130
Ensembl chr15:66,504,959...66,550,130
JBrowse link
G ZWINT ZW10 interacting kinetochore protein involved_in IDA (PMID:15485811) HGNC-UCL PMID:15485811 NCBI chr10:56,357,227...56,361,273
Ensembl chr10:56,357,227...56,361,273
JBrowse link
negative regulation of metaphase/anaphase transition of meiotic cell cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MOS MOS proto-oncogene, serine/threonine kinase involved_in ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 8:56,112,942...56,113,982
Ensembl chr 8:56,112,942...56,113,982
JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO5 F-box protein 5 involved_in IDA (PMID:11988738), (PMID:16921029) UniProt PMID:11988738 PMID:16921029 NCBI chr 6:152,970,535...152,983,579
Ensembl chr 6:152,970,519...152,983,579
JBrowse link
G RAD21 RAD21 cohesin complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:116,845,934...116,874,776
Ensembl chr 8:116,845,934...116,874,776
JBrowse link
negative regulation of mitotic sister chromatid separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTTG1 PTTG1 regulator of sister chromatid separation, securin involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739
JBrowse link
G PTTG2 pituitary tumor-transforming 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:37,960,398...37,961,128
Ensembl chr 4:37,960,398...37,961,128
JBrowse link
G PTTG3P pituitary tumor-transforming 3, pseudogene involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:66,767,329...66,768,034
Ensembl chr 8:66,767,400...66,768,005
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 involved_in IMP (PMID:19229290) UniProt PMID:19229290 NCBI chr 3:32,525,974...32,570,858
Ensembl chr 3:32,525,974...32,570,858
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease involved_in IMP (PMID:23108668) UniProt PMID:23108668 NCBI chr 2:17,753,687...17,788,946
Ensembl chr 2:17,753,858...17,788,946
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 involved_in IMP
IDA
(PMID:20870947)
(PMID:8824189)
UniProt PMID:8824189 PMID:20870947 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in IMP (PMID:25743205) UniProt PMID:25743205 NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635
JBrowse link
G PCID2 PCI domain containing 2 involved_in IMP (PMID:20870947) UniProt PMID:20870947 NCBI chr13:113,165,002...113,209,467
Ensembl chr13:113,177,536...113,208,715
JBrowse link
G TPR translocated promoter region, nuclear basket protein involved_in IMP (PMID:18981471), (PMID:19273613) UniProt PMID:18981471 PMID:19273613 NCBI chr 1:186,311,652...186,375,253
Ensembl chr 1:186,311,652...186,375,693
JBrowse link
G XRCC3 X-ray repair cross complementing 3 involved_in IMP (PMID:23108668) UniProt PMID:23108668 NCBI chr14:103,697,611...103,715,486
Ensembl chr14:103,697,609...103,715,504
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 involved_in IMP
IBA
IEA
(PMID:21926987)
(PMID:21873635)
UniProt
GO_Central
InterPro
PMID:21873635 PMID:21926987 GO_REF:0000002 NCBI chr11:72,106,372...72,112,780
Ensembl chr11:72,106,378...72,112,780
JBrowse link
G CCNB1 cyclin B1 involved_in IMP (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 involved_in IBA
IDA
(PMID:21873635)
(PMID:19282672)
GO_Central
UniProt
PMID:19282672 PMID:21873635 NCBI chr 9:120,388,875...120,580,167
Ensembl chr 9:120,388,869...120,580,170
JBrowse link
G DUSP1 dual specificity phosphatase 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within IMP (PMID:17724024) MGI PMID:17724024 NCBI chr16:25,111,702...25,178,231
Ensembl chr16:25,111,731...25,178,231
JBrowse link
G USP44 ubiquitin specific peptidase 44 involved_in ISS UniProt GO_REF:0000024 NCBI chr12:95,516,560...95,551,529
Ensembl chr12:95,516,560...95,551,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18532
    negative regulation of biological process 5939
      negative regulation of cellular process 5409
        negative regulation of chromosome segregation 50
          negative regulation of chromosome separation 49
            negative regulation of meiotic chromosome separation + 3
            negative regulation of mitotic sister chromatid separation + 47
Path 2
Term Annotations click to browse term
  biological_process 18532
    biological regulation 13076
      regulation of biological process 12362
        negative regulation of biological process 5939
          negative regulation of cellular process 5409
            negative regulation of cell cycle 399
              negative regulation of cell cycle process 305
                negative regulation of chromosome separation 49
                  negative regulation of meiotic chromosome separation + 3
                  negative regulation of mitotic sister chromatid separation + 47
paths to the root