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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of chromosome separation
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Accession:GO:1905819 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation.
Synonyms:exact_synonym: down regulation of chromosome separation;   downregulation of chromosome separation
 narrow_synonym: down regulation of rDNA separation;   downregulation of rDNA separation;   inhibition of chromosome separation;   inhibition of rDNA separation;   negative regulation of rDNA separation
 related_synonym: down regulation of chromatid release;   downregulation of chromatid release;   inhibition of chromatid release;   negative regulation of chromatid release


show annotations for term's descendants           Sort by:
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:19,434,782...19,744,574
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO
IEA		 (PMID:18022368)
GO_REF:0000107		 RGD
Ensembl		 PMID:18022368 GO_REF:0000107 NCBI chr 9:22,329,699...22,334,024
Ensembl chr 9:14,832,132...14,837,447 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:24374861)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:24374861 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:204,312,723...204,316,519
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
meiotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttk Ttk protein kinase involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
MGI:5056148 (PMID:21558374)		 GO_Central
Ensembl
RGD		 PMID:21558374 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
meiotic spindle checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chfr checkpoint with forkhead and ring finger domains involved_in ISO
IEA		 (PMID:10935642)
GO_REF:0000107		 RGD
Ensembl		 PMID:10935642 GO_REF:0000107 NCBI chr12:52,164,214...52,197,860
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO (PMID:17227893) RGD PMID:17227893 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:11943150) RGD PMID:11943150 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 involved_in ISO
ISS		 (PMID:12805209)
GO_REF:0000024		 RGD
UniProt		 PMID:12805209 GO_REF:0000024 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in ISO
IEA
IBA		 (PMID:18995837)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:18995837 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B involved_in ISO
IEA
IBA		 (PMID:10477750), (PMID:20220147)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:10477750 PMID:20220147 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:12925705) RGD PMID:12925705 NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Haspin histone H3 associated protein kinase involved_in ISO
IEA		 (PMID:23071153)
GO_REF:0000107		 RGD
Ensembl		 PMID:23071153 GO_REF:0000107 NCBI chr10:58,246,244...58,249,031
Ensembl chr10:57,747,573...57,750,512 		JBrowse link
G Ik IK cytokine involved_in ISS
ISO		 GO_REF:0000024
(PMID:22351768)		 UniProt
RGD		 PMID:22351768 GO_REF:0000024 NCBI chr18:28,632,025...28,646,829
Ensembl chr18:28,357,977...28,378,832 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member acts_upstream_of_or_within ISO MGI:3844604 (PMID:19376971) RGD PMID:19376971 NCBI chr 8:82,722,980...82,724,884
Ensembl chr 8:73,842,344...73,844,248 		JBrowse link
G Klhl22 kelch-like family member 22 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23455478)		 UniProt
RGD		 PMID:23455478 GO_REF:0000024 NCBI chr11:96,695,168...96,736,079
Ensembl chr11:83,190,891...83,231,770 		JBrowse link
G Kntc1 kinetochore associated 1 involved_in ISO
IEA
IBA		 (PMID:11146660)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:11146660 GO_REF:0000033 GO_REF:0000107 NCBI chr12:38,429,925...38,500,564
Ensembl chr12:32,769,020...32,839,561 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO
IEA
IBA		 (PMID:18981471), (PMID:36322655), (PMID:9546394)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033		 RGD
InterPro
Ensembl
GO_Central		 PMID:9546394 PMID:18981471 PMID:36322655 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:19,434,782...19,744,574
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:18981471)
GO_REF:0000107
MGI:2178781 (PMID:11201745)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:11201745 PMID:18981471 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:23455478)		 Ensembl
UniProt
RGD		 PMID:23455478 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Psmg2 proteasome assembly chaperone 2 acts_upstream_of_or_within ISO (PMID:12147697) RGD PMID:12147697 NCBI chr18:63,478,620...63,493,193
Ensembl chr18:61,208,678...61,259,816 		JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:19,773,456...19,798,341
Ensembl chr10:19,269,127...19,294,127 		JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(PMID:22405274)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024		 Ensembl
RGD
GO_Central
InterPro
UniProt		 PMID:22405274 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:72,729,017...72,859,697
Ensembl chr10:72,231,801...72,355,805 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO
IEA
ISS		 (PMID:20133940)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20133940 GO_REF:0000024 GO_REF:0000107 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in ISO
IEA
ISS		 (PMID:28553959)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28553959 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:31,185,700...31,230,638
Ensembl chr 1:29,357,130...29,402,074 		JBrowse link
G Ttk Ttk protein kinase involved_in ISO
IEA
IBA		 MGI:5056148 (PMID:25197064)
GO_REF:0000107
GO_REF:0000033
(PMID:18243099)		 RGD
Ensembl
GO_Central		 PMID:18243099 PMID:25197064 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
G Zfp207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) RGD PMID:24462186 PMID:24462187 NCBI chr10:65,883,630...65,895,895
Ensembl chr10:65,385,740...65,397,386 		JBrowse link
G Zw10 zw10 kinetochore protein involved_in ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:11146660), (PMID:15824131)		 HGNC-UCL
Ensembl
GO_Central
RGD		 PMID:11146660 PMID:15824131 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:58,292,959...58,317,881
Ensembl chr 8:49,396,545...49,421,805 		JBrowse link
G Zwilch zwilch kinetochore protein involved_in ISO
IEA
IBA		 (PMID:15824131)
GO_REF:0000107
GO_REF:0000104
GO_REF:0000033		 RGD
Ensembl
UniProt
GO_Central		 PMID:15824131 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 8:73,532,968...73,566,214
Ensembl chr 8:64,637,672...64,675,916 		JBrowse link
G Zwint ZW10 interacting kinetochore protein involved_in ISO
IBA		 (PMID:15485811)
GO_REF:0000033		 RGD
GO_Central		 PMID:15485811 GO_REF:0000033 NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,938,157...15,953,957 		JBrowse link
negative regulation of metaphase/anaphase transition of meiotic cell cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mos MOS proto-oncogene, serine/threonine kinase involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:12533425)
GO_REF:0000033
(PMID:8015609), (PMID:8015610)		 UniProt
Ensembl
RGD
GO_Central		 PMID:8015609 PMID:8015610 PMID:12533425 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:21,657,549...21,658,856
Ensembl chr 5:16,859,957...16,861,264 		JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 involved_in ISO
IEA		 (PMID:11988738), (PMID:16921029)
GO_REF:0000107		 RGD
Ensembl		 PMID:11988738 PMID:16921029 GO_REF:0000107 NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Rad21 RAD21 cohesin complex component involved_in ISO
IEA		 (PMID:10375619)
GO_REF:0000107		 RGD
Ensembl		 PMID:10375619 GO_REF:0000107 NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO
IEA		 (PMID:17443180)
GO_REF:0000107		 RGD
Ensembl		 PMID:17443180 GO_REF:0000107 NCBI chr 7:30,251,142...30,301,185
Ensembl chr 7:28,364,033...28,410,053 		JBrowse link
negative regulation of mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ska1 spindle and kinetochore associated complex subunit 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:26981768)		 UniProt
Ensembl
RGD		 PMID:26981768 GO_REF:0000024 GO_REF:0000107 NCBI chr18:70,069,957...70,080,303
Ensembl chr18:67,794,725...67,805,037 		JBrowse link
G Ska3 spindle and kinetochore associated complex subunit 3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19646878)		 UniProt
Ensembl
RGD		 PMID:19646878 GO_REF:0000024 GO_REF:0000107 NCBI chr15:36,067,372...36,086,563
Ensembl chr15:31,951,825...31,971,010 		JBrowse link
positive regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Knl1 kinetochore scaffold 1 involved_in ISO (PMID:35167144) RGD PMID:35167144 NCBI chr 3:126,483,498...126,545,774
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19229290)		 UniProt
Ensembl
RGD		 PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:114,376,662...114,410,934 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:39,666,675...39,697,480
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO
IEA		 (PMID:22898774), (PMID:36322655)
GO_REF:0000107		 RGD
Ensembl		 PMID:22898774 PMID:36322655 GO_REF:0000107 NCBI chr12:19,434,782...19,744,574
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:22898774), (PMID:8824189) RGD PMID:8824189 PMID:22898774 NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO
IEA		 (PMID:25743205)
GO_REF:0000107		 RGD
Ensembl		 PMID:25743205 GO_REF:0000107 NCBI chr 9:118,853,806...118,887,582
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18981471), (PMID:19273613)		 UniProt
Ensembl
RGD		 PMID:18981471 PMID:19273613 GO_REF:0000024 GO_REF:0000107 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO
IEA		 (PMID:23108668)
GO_REF:0000107		 RGD
Ensembl		 PMID:23108668 GO_REF:0000107 NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zwint ZW10 interacting kinetochore protein involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:26486467)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:26486467 GO_REF:0000024 GO_REF:0000107 NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,938,157...15,953,957 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO
IEA
IBA
ISS		 (PMID:21926987)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024		 RGD
Ensembl
GO_Central
InterPro
UniProt		 PMID:21926987 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:165,650,478...165,678,004
Ensembl chr 1:156,262,841...156,268,145 		JBrowse link
G Ccnb1 cyclin B1 involved_in ISO
IEA		 (PMID:18195732)
GO_REF:0000107		 RGD
Ensembl		 PMID:18195732 GO_REF:0000107 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(PMID:19282672)
GO_REF:0000107		 UniProt
GO_Central
RGD
Ensembl		 PMID:19282672 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:88,807,402...88,976,005
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO
IEA		 (PMID:19893618)
GO_REF:0000107		 RGD
Ensembl		 PMID:19893618 GO_REF:0000107 NCBI chr 3:126,483,498...126,545,774
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:17724024)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:17724024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:187,335,173...187,391,195
Ensembl chr 1:177,904,139...177,960,112 		JBrowse link
G Prpf4b pre-mRNA processing factor 4B involved_in ISS
ISO		 GO_REF:0000024
(PMID:17998396)		 UniProt
RGD		 PMID:17998396 GO_REF:0000024 NCBI chr17:30,190,721...30,230,153
Ensembl chr17:29,985,343...30,019,625 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO
IEA		 (PMID:21853124)
GO_REF:0000107		 RGD
Ensembl		 PMID:21853124 GO_REF:0000107 NCBI chr 7:30,251,142...30,301,185
Ensembl chr 7:28,364,033...28,410,053 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cell cycle process 1322
        chromosome separation 76
          negative regulation of chromosome separation 44
            negative regulation of meiotic chromosome separation + 5
            negative regulation of mitotic sister chromatid separation + 42
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        regulation of cellular process 13030
          regulation of cell cycle 1080
            regulation of cell cycle process 758
              regulation of chromosome segregation 102
                negative regulation of chromosome segregation 46
                  negative regulation of chromosome separation 44
                    negative regulation of meiotic chromosome separation + 5
                    negative regulation of mitotic sister chromatid separation + 42
paths to the root