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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of blood-brain barrier permeability
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Accession:GO:1905603 term browser browse the term
Definition:Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain.
Synonyms:exact_synonym: regulation of BBB permeability
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


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regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZEB2 zinc finger E-box binding homeobox 2 ISO RGD PMID:34334113 RGD:155882538 NCBI chr19:46,419,812...46,541,888
Ensembl chr19:46,423,998...46,542,122 		JBrowse link
negative regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO RGD PMID:18854840 RGD:2325137 NCBI chr21:39,963,001...40,037,040
Ensembl chr21:39,962,947...40,036,981 		JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:37,720,793...37,769,027
Ensembl chr11:37,577,053...37,767,572 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
positive regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT1 angiopoietin 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618 		JBrowse link
G OCLN occludin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430 		JBrowse link
G TJP1 tight junction protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
G TJP2 tight junction protein 2 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 1:88,126,134...88,251,018
Ensembl chr 1:88,126,136...88,230,654 		JBrowse link
G TJP3 tight junction protein 3 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr20:55,720,632...55,746,776
Ensembl chr20:55,720,632...55,746,965 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17428
    biological regulation 12359
      regulation of biological quality 3263
        regulation of vascular permeability 52
          regulation of blood-brain barrier permeability 9
            negative regulation of blood-brain barrier permeability 3
            positive regulation of blood-brain barrier permeability 5
Path 2
Term Annotations click to browse term
  biological_process 17428
    homeostatic process 1891
      multicellular organismal-level homeostasis 906
        anatomical structure homeostasis 296
          tissue homeostasis 295
            maintenance of blood-brain barrier 23
              regulation of blood-brain barrier permeability 9
                negative regulation of blood-brain barrier permeability 3
                positive regulation of blood-brain barrier permeability 5
paths to the root