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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of low-density lipoprotein receptor activity
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Accession:GO:1905598 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity.
Synonyms:exact_synonym: down regulation of LDL receptor;   down regulation of LDLR activity;   down regulation of low-density lipoprotein receptor activity;   downregulation of LDL receptor;   downregulation of LDLR activity;   downregulation of low-density lipoprotein receptor activity;   negative regulation of LDL receptor;   negative regulation of LDLR activity
 narrow_synonym: inhibition of LDL receptor;   inhibition of LDLR activity;   inhibition of low-density lipoprotein receptor activity


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negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO PMID:21810484
(MGI:5306885|PMID:21810484)
(PMID:21810484)
ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chrNW_004936669:922,978...941,996 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Itgav integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G LOC101959175 amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chrNW_004936522:6,271,339...6,300,202 JBrowse link
G Psen1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004936488:2,464,623...2,528,807 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12145
    biological regulation 8898
      regulation of molecular function 2181
        negative regulation of molecular function 882
          negative regulation of low-density lipoprotein receptor activity 7
Path 2
Term Annotations click to browse term
  biological_process 12145
    localization 4849
      establishment of localization 3464
        transport 3301
          regulation of transport 1698
            regulation of vesicle-mediated transport 556
              regulation of endocytosis 228
                negative regulation of endocytosis 47
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of low-density lipoprotein receptor activity 7
paths to the root