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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of low-density lipoprotein receptor activity
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Accession:GO:1905598 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity.
Synonyms:exact_synonym: down regulation of LDL receptor;   down regulation of LDLR activity;   down regulation of low-density lipoprotein receptor activity;   downregulation of LDL receptor;   downregulation of LDLR activity;   downregulation of low-density lipoprotein receptor activity;   negative regulation of LDL receptor;   negative regulation of LDLR activity
 narrow_synonym: inhibition of LDL receptor;   inhibition of LDLR activity;   inhibition of low-density lipoprotein receptor activity


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negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of IDA
ISO
PMID:21810484
(MGI:5306885|PMID:21810484)
(PMID:21810484)
RGD PMID:21810484, PMID:21810484 MGI:5306885, RGD:14697730 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) RGD PMID:11222466 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G App amyloid beta precursor protein NOT|involved_in ISO UniProtKB:P35951|UniProtKB:P49768 (PMID:20005821) RGD PMID:20005821 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Itgav integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Psen1 presenilin 1 NOT|involved_in ISO UniProtKB:P05067|UniProtKB:P35951 (PMID:20005821) RGD PMID:20005821 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    biological regulation 13612
      regulation of molecular function 3154
        negative regulation of molecular function 1208
          negative regulation of low-density lipoprotein receptor activity 7
Path 2
Term Annotations click to browse term
  biological_process 19634
    localization 6435
      establishment of localization 4860
        transport 4697
          regulation of transport 1989
            regulation of vesicle-mediated transport 636
              regulation of endocytosis 242
                negative regulation of endocytosis 50
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of low-density lipoprotein receptor activity 7
paths to the root