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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of low-density lipoprotein receptor activity
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Accession:GO:1905598 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity.
Synonyms:exact_synonym: down regulation of LDL receptor;   down regulation of LDLR activity;   down regulation of low-density lipoprotein receptor activity;   downregulation of LDL receptor;   downregulation of LDLR activity;   downregulation of low-density lipoprotein receptor activity;   negative regulation of LDL receptor;   negative regulation of LDLR activity
 narrow_synonym: inhibition of LDL receptor;   inhibition of LDLR activity;   inhibition of low-density lipoprotein receptor activity


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negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
(MGI:5306885|PMID:21810484)
ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844
JBrowse link
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
JBrowse link
G ITGAV integrin subunit alpha V involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15215180) Ensembl
BHF-UCL
PMID:15215180 GO_REF:0000107 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
JBrowse link
G ITGB3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451
JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 5:54,197,211...54,210,724 JBrowse link
G PSEN1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16153
    biological regulation 11639
      regulation of molecular function 2945
        negative regulation of molecular function 1113
          negative regulation of low-density lipoprotein receptor activity 7
Path 2
Term Annotations click to browse term
  biological_process 16153
    localization 6020
      establishment of localization 4480
        transport 4319
          regulation of transport 1885
            regulation of vesicle-mediated transport 610
              regulation of endocytosis 240
                negative regulation of endocytosis 49
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of low-density lipoprotein receptor activity 7
paths to the root