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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of low-density lipoprotein receptor activity
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Accession:GO:1905598 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity.
Synonyms:exact_synonym: down regulation of LDL receptor;   down regulation of LDLR activity;   down regulation of low-density lipoprotein receptor activity;   downregulation of LDL receptor;   downregulation of LDLR activity;   downregulation of low-density lipoprotein receptor activity;   negative regulation of LDL receptor;   negative regulation of LDLR activity
 narrow_synonym: inhibition of LDL receptor;   inhibition of LDLR activity;   inhibition of low-density lipoprotein receptor activity


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negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
(MGI:5306885|PMID:21810484)
ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
JBrowse link
G App amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Itgav integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chrNW_004955403:11,588,536...11,669,809
Ensembl chrNW_004955403:11,592,339...11,659,297
JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chrNW_004955478:9,788,192...9,830,254 JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chrNW_004955464:4,424,583...4,439,805
Ensembl chrNW_004955464:4,425,435...4,439,842
JBrowse link
G Psen1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11951
    biological regulation 8776
      regulation of molecular function 2162
        negative regulation of molecular function 875
          negative regulation of low-density lipoprotein receptor activity 7
Path 2
Term Annotations click to browse term
  biological_process 11951
    localization 4793
      establishment of localization 3426
        transport 3266
          regulation of transport 1685
            regulation of vesicle-mediated transport 548
              regulation of endocytosis 227
                negative regulation of endocytosis 48
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of low-density lipoprotein receptor activity 7
paths to the root