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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of low-density lipoprotein receptor activity
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Accession:GO:1905598 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity.
Synonyms:exact_synonym: down regulation of LDL receptor;   down regulation of LDLR activity;   down regulation of low-density lipoprotein receptor activity;   downregulation of LDL receptor;   downregulation of LDLR activity;   downregulation of low-density lipoprotein receptor activity;   negative regulation of LDL receptor;   negative regulation of LDLR activity
 narrow_synonym: inhibition of LDL receptor;   inhibition of LDLR activity;   inhibition of low-density lipoprotein receptor activity


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negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
(MGI:5306885|PMID:21810484)
ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
G ITGAV integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
JBrowse link
G ITGB3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr17:10,134,450...10,194,596 JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 1:54,323,036...54,355,397
Ensembl chr 1:55,911,016...55,936,456
JBrowse link
G PSEN1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12629
    biological regulation 9228
      regulation of molecular function 2250
        negative regulation of molecular function 906
          negative regulation of low-density lipoprotein receptor activity 7
Path 2
Term Annotations click to browse term
  biological_process 12629
    localization 4974
      establishment of localization 3548
        transport 3385
          regulation of transport 1748
            regulation of vesicle-mediated transport 568
              regulation of endocytosis 234
                negative regulation of endocytosis 49
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of low-density lipoprotein receptor activity 7
paths to the root