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ONTOLOGY REPORT - ANNOTATIONS


Term:midbrain dopaminergic neuron differentiation
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Accession:GO:1904948 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.
Synonyms:exact_synonym: DA neurogenesis from midbrain floor plate;   mDA neuron differentiation;   midbrain DA neurogenesis;   midbrain dopaminergic neuron production



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midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:3836885|PMID:19122665)
Ensembl
RGD
PMID:19122665 GO_REF:0000107 MGI:3836885 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha involved_in ISO (MGI:5705221|PMID:19951692) RGD PMID:19951692 MGI:5705221 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (MGI:3829860|PMID:18953410), (MGI:5466648|PMID:23109420) RGD PMID:18953410 PMID:23109420 MGI:3829860 MGI:5466648 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Ryk receptor-like tyrosine kinase involved_in ISO (MGI:5707582|PMID:23517308) RGD PMID:23517308 MGI:5707582 NCBI chr 8:103,419,348...103,492,083
Ensembl chr 8:103,419,275...103,491,698
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5469218|PMID:23324743) RGD PMID:23324743 MGI:5469218 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt2 Wnt family member 2 involved_in ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO UniProtKB:P04426 (MGI:2679774|PMID:14557550), (MGI:3829860|PMID:18953410), (MGI:5469218|PMID:23324743), (MGI:5700308|PMID:15748172) RGD PMID:14557550 PMID:15748172 PMID:18953410 PMID:23324743 MGI:2679774 MGI:3829860 MGI:5469218 MGI:5700308 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Wnt9b Wnt family member 9B involved_in ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035
JBrowse link
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5705221|PMID:19951692) RGD PMID:19951692 MGI:5705221 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt2 Wnt family member 2 involved_in ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Wnt3 Wnt family member 3 involved_in IEA
ISO
GO_REF:0000107
(PMID:25640183)
Ensembl
RGD
PMID:25640183 GO_REF:0000107 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt9b Wnt family member 9B involved_in ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035
JBrowse link
positive regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:4948425|PMID:21347250) RGD PMID:21347250 MGI:4948425 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csnk1e casein kinase 1, epsilon involved_in NAS PMID:17244647 ParkinsonsUK-UCL PMID:17244647 RGD:10448953 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P97299 (MGI:5448935|PMID:22290867)
Ensembl
RGD
PMID:22290867 GO_REF:0000107 MGI:5448935 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO UniProtKB:Q8C4U3 (MGI:5448935|PMID:22290867) RGD PMID:22290867 MGI:5448935 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
(MGI:5707582|PMID:23517308)
Ensembl
RGD
PMID:23517308 GO_REF:0000107 MGI:5707582 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    developmental process 6778
      anatomical structure development 6203
        midbrain development 98
          midbrain dopaminergic neuron differentiation 13
            Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + 6
            negative regulation of midbrain dopaminergic neuron differentiation 0
            positive regulation of midbrain dopaminergic neuron differentiation + 2
            regulation of midbrain dopaminergic neuron differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 19390
    developmental process 6778
      anatomical structure development 6203
        multicellular organism development 5641
          system development 5310
            nervous system development 2733
              neurogenesis 1955
                generation of neurons 1798
                  neuron differentiation 1627
                    dopaminergic neuron differentiation 37
                      midbrain dopaminergic neuron differentiation 13
                        Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + 6
                        negative regulation of midbrain dopaminergic neuron differentiation 0
                        positive regulation of midbrain dopaminergic neuron differentiation + 2
                        regulation of midbrain dopaminergic neuron differentiation + 4
paths to the root