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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
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Accession:GO:1904925 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondrion in response to mitochondrial depolarization.
Synonyms:exact_synonym: up regulation of mitophagy in response to mitochondrial depolarization;   upregulation of mitophagy in response to mitochondrial depolarization
 narrow_synonym: activation of mitophagy in response to mitochondrial depolarization


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positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IMP (PMID:24005319) ParkinsonsUK-UCL PMID:24005319 NCBI chr 1:28,236,124...28,238,100
Ensembl chr 1:28,236,109...28,246,906 		JBrowse link
G GBA1 glucosylceramidase beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5501380|PMID:23707074) Ensembl
ARUK-UCL		 PMID:23707074 GO_REF:0000107 MGI:5501380 NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699 		JBrowse link
G HK2 hexokinase 2 involved_in IMP (PMID:23962723) ParkinsonsUK-UCL PMID:23962723 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:20,499,448...20,508,151
Ensembl chr 1:20,499,448...20,508,151 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:25154397 GO_REF:0000107 RGD:12904014 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VPS13C vacuolar protein sorting 13 homolog C involved_in IMP (PMID:26942284) ParkinsonsUK-UCL PMID:26942284 NCBI chr15:61,852,389...62,060,447
Ensembl chr15:61,852,389...62,060,473 		JBrowse link
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IGI (PMID:20457763) ParkinsonsUK-UCL PMID:20457763 NCBI chr  X:48,801,398...48,824,982
Ensembl chr  X:48,801,377...48,824,982 		JBrowse link
G MFN2 mitofusin 2 involved_in IEA
ISS		 Ensembl
ParkinsonsUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G OPTN optineurin involved_in IMP (PMID:25294927) ParkinsonsUK-UCL PMID:25294927 NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IDA (PMID:19029340) ParkinsonsUK-UCL PMID:19029340 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5298125|PMID:22020285) ParkinsonsUK-UCL PMID:22020285 MGI:5298125 NCBI chr 7:99,027,440...99,144,108
Ensembl chr 7:99,027,440...99,144,108 		JBrowse link
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:10,391,133...10,403,542
Ensembl chr19:10,391,133...10,420,121 		JBrowse link
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,801,398...48,824,982
Ensembl chr  X:48,801,377...48,824,982 		JBrowse link
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 involved_in IDA (PMID:30217973) CACAO PMID:30217973 NCBI chr  X:53,532,096...53,686,719
Ensembl chr  X:53,532,096...53,686,752 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IMP (PMID:20871098) ParkinsonsUK-UCL PMID:20871098 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IDA
IMP		 (PMID:20457763)
(PMID:20871098), (PMID:23212910)		 ParkinsonsUK-UCL PMID:20457763 PMID:20871098 PMID:23212910 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G TOMM7 translocase of outer mitochondrial membrane 7 involved_in IMP (PMID:24270810) ParkinsonsUK-UCL PMID:24270810 NCBI chr 7:22,812,974...22,822,849
Ensembl chr 7:22,812,628...22,822,849 		JBrowse link
positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VDAC1 voltage dependent anion channel 1 involved_in IMP (PMID:32047033) UniProt PMID:32047033 NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      process utilizing autophagic mechanism 638
        autophagy 638
          autophagy of mitochondrion 86
            positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 15
              positive regulation of mitophagy in response to mitochondrial depolarization + 11
Path 2
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      cellular component organization or biogenesis 7533
        cellular component organization 7308
          organelle organization 3966
            mitochondrion organization 567
              autophagy of mitochondrion 86
                regulation of autophagy of mitochondrion in response to mitochondrial depolarization 16
                  positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 15
                    positive regulation of mitophagy in response to mitochondrial depolarization + 11
paths to the root