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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of vascular associated smooth muscle cell proliferation
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Accession:GO:1904707 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
Synonyms:exact_synonym: positive regulation of VSMC proliferation;   positive regulation of vascular smooth muscle cell proliferation;   up regulation of VSMC proliferation;   up regulation of vascular smooth muscle cell proliferation;   upregulation of VSMC proliferation;   upregulation of vascular smooth muscle cell proliferation
 narrow_synonym: activation of VSMC proliferation;   activation of vascular smooth muscle cell proliferation



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positive regulation of vascular associated smooth muscle cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 involved_in ISO
IEA
RNAcentral:URS00003A19A3_9606 (PMID:28890348)
GO_REF:0000107
RGD
Ensembl
PMID:28890348 GO_REF:0000107 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Agt angiotensinogen IDA RGD PMID:24595849 RGD:11039416 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within ISO MGI:1857147 (MGI:4367529|PMID:19508861) RGD PMID:19508861 MGI:4367529 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:18667463)
(MGI:3810850|PMID:18667463)
RGD PMID:18667463 MGI:3810850 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Calcrl calcitonin receptor like receptor acts_upstream_of_or_within ISO (MGI:3619781|PMID:16537897) RGD PMID:16537897 MGI:3619781 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta IMP RGD PMID:17267544 RGD:2303063 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 IMP RGD PMID:16087782 RGD:150429767 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Ddx39b DExD-box helicase 39B IMP RGD PMID:23246467 RGD:10401139 NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996
JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in ISO
IEA
(PMID:27021683)
GO_REF:0000107
RGD
Ensembl
PMID:27021683 GO_REF:0000107 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Edn1 endothelin 1 involved_in IDA PMID:28484848 BHF-UCL PMID:28484848 RGD:13601996 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:26315405) RGD PMID:26315405 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fgf2 fibroblast growth factor 2 involved_in ISO UniProtKB:Q9ULZ1 (PMID:23263626) RGD PMID:23263626 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf9 fibroblast growth factor 9 involved_in ISO
IMP
RNAcentral:URS0000355E82_9606 (PMID:29118903)
PMID:28259995
RGD PMID:29118903 PMID:28259995 RGD:13601993 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IMP RGD PMID:15292181 RGD:2289848 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Foxj2 forkhead box J2 involved_in ISO (PMID:24792364) RGD PMID:24792364 NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 involved_in IMP PMID:28947594 BHF-UCL PMID:28947594 RGD:13524616 NCBI chr 7:52,711,255...52,792,758
Ensembl chr 7:52,711,257...52,792,743
JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of ISO (PMID:28342807) RGD PMID:28342807 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:27773680 PMID:24018045 RGD:13513992, RGD:13792711 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase IMP RGD PMID:24657469 RGD:11667099 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO (PMID:25871906) RGD PMID:25871906 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
(PMID:26166810)
GO_REF:0000107
RGD
Ensembl
PMID:26166810 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO RNAcentral:URS00001E3523_9606 (PMID:29016699) RGD PMID:29016699 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:23516544 RGD:10403075 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit involved_in ISO (PMID:28701355) RGD PMID:28701355 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:28257760) RGD PMID:28257760 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IMP RGD PMID:14638553 RGD:10412321 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IMP RGD PMID:35078016 RGD:155804282 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mdm2 MDM2 proto-oncogene IMP RGD PMID:21498419 RGD:10412065 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mef2d myocyte enhancer factor 2D involved_in ISO
IEA
RNAcentral:URS0000355E82_9606 (PMID:29118903)
GO_REF:0000107
RGD
Ensembl
PMID:29118903 GO_REF:0000107 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
JBrowse link
G Mfn2 mitofusin 2 involved_in ISO (PMID:27640178) RGD PMID:27640178 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir125a microRNA 125a IMP RGD PMID:30156956 RGD:26884369 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
JBrowse link
G Mir130a microRNA 130a involved_in ISO (PMID:24960162), (PMID:25681685) RGD PMID:24960162 PMID:25681685 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir135b microRNA 135b involved_in ISO (PMID:26184978) RGD PMID:26184978 NCBI chr13:43,638,857...43,638,953
Ensembl chr13:43,638,857...43,638,953
JBrowse link
G Mir146a microRNA 146a acts_upstream_of ISO (PMID:30779466) RGD PMID:30779466 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir17 microRNA 17 involved_in ISO (PMID:22161164), (PMID:27640178) RGD PMID:22161164 PMID:27640178 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:22450430), (PMID:25447536) RGD PMID:22450430 PMID:25447536 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:20693317), (PMID:21817107), (PMID:22034194), (PMID:26208095), (PMID:28522568) RGD PMID:20693317 PMID:21817107 PMID:22034194 PMID:26208095 PMID:28522568 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir214 microRNA 214 involved_in ISO (PMID:27144530), (PMID:28684904) RGD PMID:27144530 PMID:28684904 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:19088079) RGD PMID:19088079 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir222 microRNA 222 IMP RGD PMID:28854428 RGD:152025191 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Mir26a microRNA 26a involved_in ISO (PMID:20857419) RGD PMID:20857419 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
JBrowse link
G Mir301a microRNA 301a involved_in ISO (PMID:25681685) RGD PMID:25681685 NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435
JBrowse link
G Mir448 microRNA 448 involved_in ISO (PMID:28799067) RGD PMID:28799067 NCBI chr  X:110,829,918...110,830,029
Ensembl chr  X:110,829,918...110,830,029
JBrowse link
G Mir499a microRNA 499a involved_in ISO (PMID:26184978) RGD PMID:26184978 NCBI chr 3:144,110,469...144,110,533
Ensembl chr 3:144,110,469...144,110,533
JBrowse link
G Mmp2 matrix metallopeptidase 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:18667463)
Ensembl
RGD
PMID:18667463 GO_REF:0000107 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in IEA
ISO
GO_REF:0000107
(PMID:18667463)
Ensembl
RGD
PMID:18667463 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:97528 (MGI:3629249|PMID:16644864)
GO_REF:0000107
RGD
Ensembl
PMID:16644864 GO_REF:0000107 MGI:3629249 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 IMP RGD PMID:22508052 RGD:11073699 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in ISO RNAcentral:URS000075DB2F_9606 (PMID:23554459) RGD PMID:23554459 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 involved_in ISO (PMID:28277742) RGD PMID:28277742 NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:19901155 RGD:11533949 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:12070119), (PMID:19088079), (PMID:23554459)
MGI:97306 (MGI:3629249|PMID:16644864)
Ensembl
RGD
PMID:12070119 PMID:16644864 PMID:19088079 PMID:23554459 GO_REF:0000107 MGI:3629249 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IMP in response to hypoxia RGD PMID:22527940 RGD:7242177 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IMP RGD PMID:9227431 RGD:150521729 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tert telomerase reverse transcriptase IMP RGD PMID:24376652 RGD:11038675 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (MGI:5796069|PMID:26808574) RGD PMID:26808574 MGI:5796069 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xbp1 X-box binding protein 1 involved_in
NOT|involved_in
ISO (PMID:26315405) RGD PMID:26315405 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    cellular process 18295
      positive regulation of cellular process 6022
        positive regulation of cell population proliferation 1120
          positive regulation of smooth muscle cell proliferation 136
            positive regulation of vascular associated smooth muscle cell proliferation 59
Path 2
Term Annotations click to browse term
  biological_process 19898
    biological regulation 13573
      regulation of biological process 13161
        regulation of cellular process 12368
          regulation of cell population proliferation 1922
            regulation of smooth muscle cell proliferation 221
              regulation of vascular associated smooth muscle cell proliferation 104
                positive regulation of vascular associated smooth muscle cell proliferation 59
paths to the root