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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of telomere maintenance via telomere lengthening
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Accession:GO:1904357 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening.
Synonyms:exact_synonym: down regulation of telomere maintenance via telomere lengthening;   downregulation of telomere maintenance via telomere lengthening
 narrow_synonym: inhibition of telomere maintenance via telomere lengthening



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negative regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit involved_in IDA (PMID:18812185) BHF-UCL PMID:18812185 NCBI chr16:13,920,137...13,952,348
Ensembl chr16:13,920,138...13,952,348
JBrowse link
G MCRS1 microspherule protein 1 involved_in IDA (PMID:15044100) BHF-UCL PMID:15044100 NCBI chr12:49,558,299...49,568,233
Ensembl chr12:49,556,544...49,568,145
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 involved_in NAS (PMID:26194824) BHF-UCL PMID:26194824 NCBI chr 8:10,764,961...10,839,875
Ensembl chr 8:10,725,399...10,839,847
Ensembl chr 8:10,725,399...10,839,847
JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in IMP (PMID:24012755) BHF-UCL PMID:24012755 NCBI chr16:30,193,843...30,197,566
Ensembl chr16:30,193,875...30,197,561
JBrowse link
G SLX1B SLX1 homolog B, structure-specific endonuclease subunit involved_in IMP (PMID:24012755) BHF-UCL PMID:24012755 NCBI chr16:29,454,501...29,458,219
Ensembl chr16:29,454,501...29,458,219
JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in IMP (PMID:24012755) BHF-UCL PMID:24012755 NCBI chr16:3,579,653...3,611,639
Ensembl chr16:3,581,181...3,611,606
JBrowse link
G TERF1 telomeric repeat binding factor 1 involved_in TAS (PMID:11854288) BHF-UCL PMID:11854288 NCBI chr 8:73,008,856...73,048,123
Ensembl chr 8:73,008,856...73,048,123
JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in IMP (PMID:24012755) BHF-UCL PMID:24012755 NCBI chr16:69,355,567...69,386,007
Ensembl chr16:69,355,567...69,408,571
JBrowse link
G TNKS tankyrase involved_in IMP (PMID:25939383) BHF-UCL PMID:25939383 NCBI chr 8:9,555,230...9,782,346
Ensembl chr 8:9,555,912...9,782,346
JBrowse link
G TNKS2 tankyrase 2 involved_in IMP (PMID:25939383) BHF-UCL PMID:25939383 NCBI chr10:91,798,426...91,865,475
Ensembl chr10:91,798,426...91,865,475
JBrowse link
negative regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACD ACD shelterin complex subunit and telomerase recruitment factor involved_in IBA
IGI
IMP
TAS
(PMID:21873635)
(PMID:15181449)
(PMID:15380063)
(PMID:17237768), (PMID:25467444)
GO_Central
BHF-UCL
PMID:15181449 PMID:15380063 PMID:17237768 PMID:21873635 PMID:25467444 NCBI chr16:67,657,512...67,660,832
Ensembl chr16:67,657,512...67,660,815
JBrowse link
G CTC1 CST telomere replication complex component 1 involved_in IDA (PMID:22763445) BHF-UCL PMID:22763445 NCBI chr17:8,224,815...8,248,079
Ensembl chr17:8,224,815...8,248,056
JBrowse link
G DCP2 decapping mRNA 2 involved_in IMP (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr 5:112,976,702...113,022,195
Ensembl chr 5:112,976,702...113,022,195
JBrowse link
G EXOSC10 exosome component 10 involved_in IMP (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr 1:11,066,613...11,099,869
Ensembl chr 1:11,066,618...11,099,869
JBrowse link
G GNL3L G protein nucleolar 3 like involved_in IMP (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr  X:54,530,219...54,567,289
Ensembl chr  X:54,530,183...54,621,521
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 involved_in IMP (PMID:23935072) BHF-UCL PMID:23935072 NCBI chr12:54,280,726...54,287,087
Ensembl chr12:54,280,193...54,287,088
JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C involved_in IMP (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr14:21,209,147...21,269,442
Ensembl chr14:21,209,136...21,269,494
JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in IBA
IMP
(PMID:21873635)
(PMID:18082603)
GO_Central
BHF-UCL
PMID:18082603 PMID:21873635 NCBI chr 1:244,850,297...244,864,543
Ensembl chr 1:244,840,638...244,864,560
JBrowse link
G NAT10 N-acetyltransferase 10 involved_in IMP (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr11:34,105,629...34,146,908
Ensembl chr11:34,105,617...34,147,670
JBrowse link
G PIF1 PIF1 5'-to-3' DNA helicase involved_in IDA (PMID:23657261) BHF-UCL PMID:23657261 NCBI chr15:64,815,632...64,827,173
Ensembl chr15:64,815,632...64,825,668
JBrowse link
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 involved_in IDA
IMP
(PMID:11701125)
(PMID:21119197)
BHF-UCL PMID:11701125 PMID:21119197 NCBI chr 8:10,764,961...10,839,875
Ensembl chr 8:10,725,399...10,839,847
Ensembl chr 8:10,725,399...10,839,847
JBrowse link
G PML PML nuclear body scaffold involved_in IMP (PMID:19567472) UniProt PMID:19567472 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827
JBrowse link
G POT1 protection of telomeres 1 involved_in TAS
IGI
(PMID:17237768)
(PMID:15181449)
BHF-UCL PMID:15181449 PMID:17237768 NCBI chr 7:124,822,386...124,929,825
Ensembl chr 7:124,822,386...124,929,983
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IMP (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STN1 STN1 subunit of CST complex involved_in IDA (PMID:22763445) BHF-UCL PMID:22763445 NCBI chr10:103,877,569...103,918,184
Ensembl chr10:103,877,569...103,918,184
JBrowse link
G TEN1 TEN1 subunit of CST complex involved_in IDA
IBA
(PMID:22763445)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:21873635 PMID:22763445 NCBI chr17:75,979,240...76,000,586
Ensembl chr17:75,979,240...76,000,586
JBrowse link
G TENT4B terminal nucleotidyltransferase 4B involved_in IMP (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr16:50,152,911...50,235,310
Ensembl chr16:50,152,911...50,235,310
JBrowse link
G TERF1 telomeric repeat binding factor 1 involved_in TAS
IGI
(PMID:16275645), (PMID:24389012)
(PMID:11971978)
BHF-UCL PMID:11971978 PMID:16275645 PMID:24389012 NCBI chr 8:73,008,856...73,048,123
Ensembl chr 8:73,008,856...73,048,123
JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in IDA
IC
IMP
(PMID:17055345)
(PMID:15657433)
(PMID:11971978)
BHF-UCL PMID:11971978 PMID:15657433 PMID:17055345 NCBI chr16:69,355,567...69,386,007
Ensembl chr16:69,355,567...69,408,571
JBrowse link
G TINF2 TERF1 interacting nuclear factor 2 involved_in IGI
IMP
(PMID:10581025)
(PMID:15133513)
BHF-UCL PMID:10581025 PMID:15133513 NCBI chr14:24,239,640...24,242,674
Ensembl chr14:24,239,643...24,242,674
JBrowse link
G XRN1 5'-3' exoribonuclease 1 involved_in IC (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr 3:142,306,610...142,448,062
Ensembl chr 3:142,306,607...142,448,062
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18605
    metabolic process 11952
      negative regulation of metabolic process 3411
        negative regulation of macromolecule metabolic process 3162
          negative regulation of DNA metabolic process 132
            negative regulation of telomere maintenance 38
              negative regulation of telomere maintenance via telomere lengthening 29
                negative regulation of telomere maintenance via telomerase 21
Path 2
Term Annotations click to browse term
  biological_process 18605
    metabolic process 11952
      cellular metabolic process 10867
        cellular aromatic compound metabolic process 6065
          nucleobase-containing compound metabolic process 5819
            nucleic acid metabolic process 5316
              DNA metabolic process 989
                telomere maintenance 154
                  regulation of telomere maintenance 98
                    negative regulation of telomere maintenance 38
                      negative regulation of telomere maintenance via telomere lengthening 29
                        negative regulation of telomere maintenance via telomerase 21
paths to the root