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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of serine C-palmitoyltransferase activity
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Accession:GO:1904221 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity.
Comment:Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
Synonyms:exact_synonym: down regulation of 3-oxosphinganine synthetase activity;   down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity;   down regulation of serine C-palmitoyltransferase activity;   downregulation of 3-oxosphinganine synthetase activity;   downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity;   downregulation of serine C-palmitoyltransferase activity;   negative regulation of 3-oxosphinganine synthetase activity;   negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity
 narrow_synonym: inhibition of 3-oxosphinganine synthetase activity;   inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity;   inhibition of serine C-palmitoyltransferase activity
 related_synonym: down regulation of SPT;   down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating;   downregulation of SPT;   downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating;   inhibition of SPT;   inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating;   negative regulation of SPT;   negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating


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negative regulation of serine C-palmitoyltransferase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 ISO MGI:2137691|MGI:6382064 (MGI:5926671|PMID:28275141), (MGI:6393026|PMID:31880535) RGD PMID:28275141 PMID:31880535 MGI:5926671 MGI:6393026 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478
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  biological_process 20030
    biological regulation 13774
      regulation of molecular function 3073
        negative regulation of molecular function 1227
          negative regulation of catalytic activity 855
            negative regulation of transferase activity 291
              negative regulation of serine C-palmitoyltransferase activity 1
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