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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of serine C-palmitoyltransferase activity
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Accession:GO:1904220 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity.
Comment:Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
Synonyms:exact_synonym: regulation of 3-oxosphinganine synthetase activity;   regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity
 broad_synonym: regulation of serine palmitoyltransferase
 related_synonym: regulation of SPT;   regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating



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regulation of serine C-palmitoyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sptssb serine palmitoyltransferase, small subunit B involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5689843 (MGI:5689923|PMID:26438849)
RGD PMID:26438849 PMID:21873635 MGI:5689923, RGD:13792537 NCBI chr 2:154,133,728...154,162,127
Ensembl chr 2:154,133,733...154,163,120
JBrowse link
negative regulation of serine C-palmitoyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2137691|MGI:6382064 (MGI:5926671|PMID:28275141), (MGI:6393026|PMID:31880535)
Ensembl
RGD
PMID:28275141 PMID:31880535 GO_REF:0000107 MGI:5926671 MGI:6393026 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620
JBrowse link
positive regulation of serine C-palmitoyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serinc1 serine incorporator 1 involved_in IDA PMID:16120614 BHF-UCL PMID:16120614 RGD:8553290 NCBI chr20:36,850,062...36,896,691
Ensembl chr20:36,850,076...36,896,691
JBrowse link
G Serinc2 serine incorporator 2 involved_in IDA PMID:16120614 BHF-UCL PMID:16120614 RGD:8553290 NCBI chr 5:142,592,308...142,614,628
Ensembl chr 5:142,592,309...142,618,364
JBrowse link
G Serinc5 serine incorporator 5 involved_in IDA PMID:16120614 BHF-UCL PMID:16120614 RGD:8553290 NCBI chr 2:23,846,899...23,950,346
Ensembl chr 2:23,846,900...23,950,346
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of molecular function 3095
        regulation of catalytic activity 2359
          regulation of transferase activity 916
            regulation of serine C-palmitoyltransferase activity 5
              negative regulation of serine C-palmitoyltransferase activity 1
              positive regulation of serine C-palmitoyltransferase activity 3
paths to the root