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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of pyruvate dehydrogenase activity
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Accession:GO:1904183 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity.
Synonyms:exact_synonym: down regulation of pyruvate dehydrogenase activity;   down regulation of pyruvic acid dehydrogenase activity;   down regulation of pyruvic dehydrogenase activity;   downregulation of pyruvate dehydrogenase activity;   downregulation of pyruvic acid dehydrogenase activity;   downregulation of pyruvic dehydrogenase activity;   negative regulation of pyruvic acid dehydrogenase activity;   negative regulation of pyruvic dehydrogenase activity
 narrow_synonym: inhibition of pyruvate dehydrogenase activity;   inhibition of pyruvic acid dehydrogenase activity;   inhibition of pyruvic dehydrogenase activity


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negative regulation of pyruvate dehydrogenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCKDK branched chain keto acid dehydrogenase kinase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:31,108,381...31,117,651
Ensembl chr16:31,106,107...31,112,791
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152
JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,270...24,550,466
Ensembl chr  X:24,465,270...24,550,466
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18651
    negative regulation of biological process 6182
      negative regulation of metabolic process 3657
        negative regulation of oxidoreductase activity 36
          negative regulation of pyruvate dehydrogenase activity 5
Path 2
Term Annotations click to browse term
  biological_process 18651
    biological regulation 13283
      regulation of molecular function 3255
        regulation of catalytic activity 2514
          negative regulation of catalytic activity 866
            negative regulation of oxidoreductase activity 36
              negative regulation of pyruvate dehydrogenase activity 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.