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ONTOLOGY REPORT - ANNOTATIONS

Term:non-ribosomal peptide synthetase activity
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Accession:GO:1904091 term browser browse the term
Definition:Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.
Comment:Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.
Synonyms:exact_synonym: peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis;   peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process
 related_synonym: PCP;   peptidyl carrier protein;   peptidyl carrier protein activity


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glutathione synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gss glutathione synthetase enables IDA
IEA
IBA
ISO		 GO_REF:0000104
GO_REF:0000033
(PMID:8660701)		 UniProt
GO_Central
RGD		 PMID:8660701 PMID:7862666 PMID:10964706 GO_REF:0000033 GO_REF:0000104, RGD:69853, RGD:1599340 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
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  molecular_function 20732
    catalytic activity 6109
      non-ribosomal peptide synthetase activity 1
        amino acid ligation activity by nonribosomal peptide synthase 0
        glutathione synthase activity 1
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