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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of spontaneous neurotransmitter secretion
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Accession:GO:1904049 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion.
Comment:An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
Synonyms:exact_synonym: down regulation of spontaneous neurotransmitter secretion;   down regulation of stimulus-independent neurotransmitter secretion;   downregulation of spontaneous neurotransmitter secretion;   downregulation of stimulus-independent neurotransmitter secretion;   negative regulation of stimulus-independent neurotransmitter secretion
 narrow_synonym: inhibition of spontaneous neurotransmitter secretion;   inhibition of stimulus-independent neurotransmitter secretion


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negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 6:4,902,872...5,165,661
Ensembl chr 6:4,902,917...5,165,661
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G Prkn parkin RBR E3 ubiquitin protein ligase ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr17:10,840,359...12,063,370
Ensembl chr17:10,840,384...12,063,361
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    signaling 6935
      negative regulation of signaling 1373
        negative regulation of synaptic transmission 82
          negative regulation of neurotransmitter secretion 12
            negative regulation of spontaneous neurotransmitter secretion 2
Path 2
Term Annotations click to browse term
  biological_process 23386
    cellular process 17420
      cell communication 7016
        cell-cell signaling 1751
          synaptic signaling 937
            trans-synaptic signaling 905
              anterograde trans-synaptic signaling 896
                chemical synaptic transmission 896
                  neurotransmitter secretion 191
                    regulation of neurotransmitter secretion 128
                      negative regulation of neurotransmitter secretion 12
                        negative regulation of spontaneous neurotransmitter secretion 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.