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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of spontaneous neurotransmitter secretion
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Accession:GO:1904049 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion.
Comment:An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
Synonyms:exact_synonym: down regulation of spontaneous neurotransmitter secretion;   down regulation of stimulus-independent neurotransmitter secretion;   downregulation of spontaneous neurotransmitter secretion;   downregulation of stimulus-independent neurotransmitter secretion;   negative regulation of stimulus-independent neurotransmitter secretion
 narrow_synonym: inhibition of spontaneous neurotransmitter secretion;   inhibition of stimulus-independent neurotransmitter secretion


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negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chr14:20,251,791...20,563,315
Ensembl chr14:20,251,738...20,557,208
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G PRKN parkin RBR E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    signaling 6001
      negative regulation of signaling 1346
        negative regulation of synaptic transmission 82
          negative regulation of neurotransmitter secretion 12
            negative regulation of spontaneous neurotransmitter secretion 2
Path 2
Term Annotations click to browse term
  biological_process 16190
    cellular process 15467
      cell communication 6076
        cell-cell signaling 1617
          synaptic signaling 865
            trans-synaptic signaling 840
              anterograde trans-synaptic signaling 831
                chemical synaptic transmission 831
                  neurotransmitter secretion 193
                    regulation of neurotransmitter secretion 129
                      negative regulation of neurotransmitter secretion 12
                        negative regulation of spontaneous neurotransmitter secretion 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.