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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of spontaneous neurotransmitter secretion
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Accession:GO:1904049 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion.
Comment:An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
Synonyms:exact_synonym: down regulation of spontaneous neurotransmitter secretion;   down regulation of stimulus-independent neurotransmitter secretion;   downregulation of spontaneous neurotransmitter secretion;   downregulation of stimulus-independent neurotransmitter secretion;   negative regulation of stimulus-independent neurotransmitter secretion
 narrow_synonym: inhibition of spontaneous neurotransmitter secretion;   inhibition of stimulus-independent neurotransmitter secretion


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negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chrNW_004955432:11,607,269...11,891,568
Ensembl chrNW_004955432:11,608,382...11,886,044
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G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:22314364) ParkinsonsUK-UCL PMID:22314364 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11893
    signaling 4144
      negative regulation of signaling 1256
        negative regulation of synaptic transmission 80
          negative regulation of neurotransmitter secretion 12
            negative regulation of spontaneous neurotransmitter secretion 2
Path 2
Term Annotations click to browse term
  biological_process 11893
    cellular process 11099
      cell communication 4210
        cell-cell signaling 1339
          synaptic signaling 654
            trans-synaptic signaling 634
              anterograde trans-synaptic signaling 627
                chemical synaptic transmission 627
                  neurotransmitter secretion 168
                    regulation of neurotransmitter secretion 119
                      negative regulation of neurotransmitter secretion 12
                        negative regulation of spontaneous neurotransmitter secretion 2
paths to the root