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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of spontaneous neurotransmitter secretion
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Accession:GO:1904049 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion.
Comment:An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
Synonyms:exact_synonym: down regulation of spontaneous neurotransmitter secretion;   down regulation of stimulus-independent neurotransmitter secretion;   downregulation of spontaneous neurotransmitter secretion;   downregulation of stimulus-independent neurotransmitter secretion;   negative regulation of stimulus-independent neurotransmitter secretion
 narrow_synonym: inhibition of spontaneous neurotransmitter secretion;   inhibition of stimulus-independent neurotransmitter secretion


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negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:16899074 RGD:10002752 NCBI chr 4:29,976,485...30,247,371
Ensembl chr 4:29,978,739...30,241,911
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:22314364) RGD PMID:22314364 NCBI chr 1:48,880,015...50,069,998 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      negative regulation of signaling 1373
        negative regulation of synaptic transmission 83
          negative regulation of neurotransmitter secretion 12
            negative regulation of spontaneous neurotransmitter secretion 2
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell communication 7661
        cell-cell signaling 1725
          synaptic signaling 917
            trans-synaptic signaling 889
              anterograde trans-synaptic signaling 880
                chemical synaptic transmission 880
                  neurotransmitter secretion 209
                    regulation of neurotransmitter secretion 140
                      negative regulation of neurotransmitter secretion 12
                        negative regulation of spontaneous neurotransmitter secretion 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.