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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spontaneous neurotransmitter secretion
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Accession:GO:1904048 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion.
Comment:An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
Synonyms:exact_synonym: regulation of stimulus-independent neurotransmitter secretion


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negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,280...74,940,362
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,511...6,730,881
JBrowse link
positive regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STX1A syntaxin 1A ISO (MGI:5603022|PMID:24587181) ParkinsonsUK-UCL PMID:24587181 MGI:5603022 NCBI chr 3:10,974,127...10,991,846
Ensembl chr 3:10,974,126...10,991,874
JBrowse link
G STX1B syntaxin 1B IEA Ensembl GO_REF:0000107 NCBI chr 3:17,439,563...17,459,517
Ensembl chr 3:17,439,581...17,459,516
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    biological regulation 12014
      regulation of biological quality 3986
        regulation of neurotransmitter levels 250
          regulation of neurotransmitter secretion 128
            regulation of spontaneous neurotransmitter secretion 4
              negative regulation of spontaneous neurotransmitter secretion 2
              positive regulation of spontaneous neurotransmitter secretion 2
Path 2
Term Annotations click to browse term
  biological_process 16548
    cellular process 15780
      cell communication 6529
        cell-cell signaling 1618
          synaptic signaling 853
            trans-synaptic signaling 824
              anterograde trans-synaptic signaling 816
                chemical synaptic transmission 816
                  neurotransmitter secretion 188
                    regulation of neurotransmitter secretion 128
                      regulation of spontaneous neurotransmitter secretion 4
                        negative regulation of spontaneous neurotransmitter secretion 2
                        positive regulation of spontaneous neurotransmitter secretion 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.