Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of PERK-mediated unfolded protein response
go back to main search page
Accession:GO:1903898 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response.
Synonyms:exact_synonym: down regulation of PERK branch of UPR;   down regulation of PERK-mediated unfolded protein response;   down regulation of PKR-like ER kinase signal transduction;   down regulation of UPR signaling by PERK stress sensor;   down regulation of endoplasmic reticulum unfolded protein response; PERK signaling;   downregulation of PERK branch of UPR;   downregulation of PERK-mediated unfolded protein response;   downregulation of PKR-like ER kinase signal transduction;   downregulation of UPR signaling by PERK stress sensor;   downregulation of endoplasmic reticulum unfolded protein response; PERK signaling;   negative regulation of PERK branch of UPR;   negative regulation of PKR-like ER kinase signal transduction;   negative regulation of UPR signaling by PERK stress sensor;   negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling
 narrow_synonym: inhibition of PERK branch of UPR;   inhibition of PERK-mediated unfolded protein response;   inhibition of PKR-like ER kinase signal transduction;   inhibition of UPR signaling by PERK stress sensor;   inhibition of endoplasmic reticulum unfolded protein response; PERK signaling
 related_synonym: down regulation of PERK signaling in response to endoplasmic reticulum stress;   downregulation of PERK signaling in response to endoplasmic reticulum stress;   inhibition of PERK signaling in response to endoplasmic reticulum stress;   negative regulation of EIF2AK3-mediated unfolded protein response;   negative regulation of PERK signaling in response to endoplasmic reticulum stress


show annotations for term's descendants           Sort by:
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A member 7 involved_in IMP (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406 		JBrowse link
G Igtp interferon gamma induced GTPase involved_in IDA (MGI:7434542|PMID:21981022) UniProt PMID:21981022 MGI:7434542 NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417 		JBrowse link
G Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 involved_in IGI
ISO
IBA		 (MGI:5613478|PMID:14676213) ParkinsonsUK-UCL
MGI
GO_Central		 PMID:14676213 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5613478 NCBI chr 9:100,376,047...100,428,187
Ensembl chr 9:100,374,346...100,428,187 		JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 involved_in IGI
IBA		 (MGI:5613478|PMID:14676213) ParkinsonsUK-UCL
GO_Central		 PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in IMP
ISO
IBA		 (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL
MGI
GO_Central		 PMID:21216966 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5619464 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      signal transduction 6675
        ER-nucleus signaling pathway 45
          PERK-mediated unfolded protein response 16
            negative regulation of PERK-mediated unfolded protein response 5
Path 2
Term Annotations click to browse term
  biological_process 28573
    response to stimulus 10772
      response to chemical 5405
        response to organic substance 3920
          response to topologically incorrect protein 141
            response to unfolded protein 123
              cellular response to unfolded protein 90
                endoplasmic reticulum unfolded protein response 75
                  regulation of endoplasmic reticulum unfolded protein response 27
                    negative regulation of endoplasmic reticulum unfolded protein response 15
                      negative regulation of PERK-mediated unfolded protein response 5
paths to the root