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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of PERK-mediated unfolded protein response
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Accession:GO:1903898 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response.
Synonyms:exact_synonym: down regulation of PERK branch of UPR;   down regulation of PERK-mediated unfolded protein response;   down regulation of PKR-like ER kinase signal transduction;   down regulation of UPR signaling by PERK stress sensor;   down regulation of endoplasmic reticulum unfolded protein response; PERK signaling;   downregulation of PERK branch of UPR;   downregulation of PERK-mediated unfolded protein response;   downregulation of PKR-like ER kinase signal transduction;   downregulation of UPR signaling by PERK stress sensor;   downregulation of endoplasmic reticulum unfolded protein response; PERK signaling;   negative regulation of PERK branch of UPR;   negative regulation of PKR-like ER kinase signal transduction;   negative regulation of UPR signaling by PERK stress sensor;   negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling
 narrow_synonym: inhibition of PERK branch of UPR;   inhibition of PERK-mediated unfolded protein response;   inhibition of PKR-like ER kinase signal transduction;   inhibition of UPR signaling by PERK stress sensor;   inhibition of endoplasmic reticulum unfolded protein response; PERK signaling
 related_synonym: down regulation of PERK signaling in response to endoplasmic reticulum stress;   downregulation of PERK signaling in response to endoplasmic reticulum stress;   inhibition of PERK signaling in response to endoplasmic reticulum stress;   negative regulation of EIF2AK3-mediated unfolded protein response;   negative regulation of PERK signaling in response to endoplasmic reticulum stress


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negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572
JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IDA
IBA
(PMID:14676213)
(PMID:21873635)
ParkinsonsUK-UCL
GO_Central
PMID:14676213 PMID:21873635 NCBI chr 3:136,862,208...136,951,606
Ensembl chr 3:136,862,208...136,951,606
JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:105,744,649...105,894,274
Ensembl chr 2:105,744,912...105,894,274
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,421...48,876,058
JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 1:204,398,684...204,412,454
Ensembl chr 1:204,403,381...204,411,817
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IDA (PMID:21216966) ParkinsonsUK-UCL PMID:21216966 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    cellular process 17456
      signal transduction 6274
        ER-nucleus signaling pathway 47
          PERK-mediated unfolded protein response 18
            negative regulation of PERK-mediated unfolded protein response 6
Path 2
Term Annotations click to browse term
  biological_process 18537
    response to stimulus 9790
      response to chemical 5359
        response to organic substance 3922
          response to topologically incorrect protein 167
            response to unfolded protein 145
              cellular response to unfolded protein 105
                endoplasmic reticulum unfolded protein response 81
                  regulation of endoplasmic reticulum unfolded protein response 32
                    negative regulation of endoplasmic reticulum unfolded protein response 17
                      negative regulation of PERK-mediated unfolded protein response 6
paths to the root