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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of PERK-mediated unfolded protein response
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Accession:GO:1903897 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response.
Synonyms:exact_synonym: regulation of PERK branch of UPR;   regulation of PKR-like ER kinase signal transduction;   regulation of UPR signaling by PERK stress sensor;   regulation of endoplasmic reticulum unfolded protein response; PERK signaling
 broad_synonym: regulation of PERK signal transduction pathway
 related_synonym: regulation of EIF2AK3-mediated unfolded protein response;   regulation of PERK signaling in response to endoplasmic reticulum stress


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regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572
JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IDA
IBA
(PMID:14676213)
(PMID:21873635)
ParkinsonsUK-UCL
GO_Central
PMID:14676213 PMID:21873635 NCBI chr 3:136,862,208...136,951,606
Ensembl chr 3:136,862,208...136,951,606
JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:105,744,649...105,894,274
Ensembl chr 2:105,744,912...105,894,274
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,421...48,876,058
JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 1:204,398,684...204,412,454
Ensembl chr 1:204,403,381...204,411,817
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IDA (PMID:21216966) ParkinsonsUK-UCL PMID:21216966 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IDA (PMID:23220234) UniProt PMID:23220234 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISS UniProt GO_REF:0000024 NCBI chr 2:241,558,745...241,574,131
Ensembl chr 2:241,551,424...241,574,131
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:12,785,478...12,884,351
Ensembl chr18:12,785,478...12,929,643
JBrowse link
G TMEM33 transmembrane protein 33 involved_in IDA (PMID:26268696) UniProt PMID:26268696 NCBI chr 4:41,935,120...41,960,803
Ensembl chr 4:41,935,129...41,960,803
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18534
    cellular process 17457
      signal transduction 6271
        ER-nucleus signaling pathway 47
          PERK-mediated unfolded protein response 18
            regulation of PERK-mediated unfolded protein response 11
              negative regulation of PERK-mediated unfolded protein response 6
              positive regulation of PERK-mediated unfolded protein response 4
Path 2
Term Annotations click to browse term
  biological_process 18534
    response to stimulus 9786
      response to chemical 5355
        response to organic substance 3917
          response to topologically incorrect protein 167
            response to unfolded protein 145
              cellular response to unfolded protein 105
                endoplasmic reticulum unfolded protein response 81
                  regulation of endoplasmic reticulum unfolded protein response 32
                    regulation of PERK-mediated unfolded protein response 11
                      negative regulation of PERK-mediated unfolded protein response 6
                      positive regulation of PERK-mediated unfolded protein response 4
paths to the root