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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of PERK-mediated unfolded protein response
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Accession:GO:1903897 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response.
Synonyms:exact_synonym: regulation of PERK branch of UPR;   regulation of PKR-like ER kinase signal transduction;   regulation of UPR signaling by PERK stress sensor;   regulation of endoplasmic reticulum unfolded protein response; PERK signaling
 broad_synonym: regulation of PERK signal transduction pathway
 related_synonym: regulation of EIF2AK3-mediated unfolded protein response;   regulation of PERK signaling in response to endoplasmic reticulum stress


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negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr20:57,668,371...57,684,111
Ensembl chr20:57,667,706...57,677,342 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr23:33,297,660...33,374,025
Ensembl chr23:33,297,756...33,372,534 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:37,584,351...37,734,388
Ensembl chr10:37,585,565...37,732,994 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chr25:51,449,700...51,450,967 JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:39,013,799...39,039,059
Ensembl chr13:39,013,855...39,052,547 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17878
    cellular process 16920
      signal transduction 6300
        ER-nucleus signaling pathway 46
          PERK-mediated unfolded protein response 15
            regulation of PERK-mediated unfolded protein response 8
              negative regulation of PERK-mediated unfolded protein response 4
              positive regulation of PERK-mediated unfolded protein response 4
Path 2
Term Annotations click to browse term
  biological_process 17878
    cellular process 16920
      cellular response to stimulus 8001
        cellular response to chemical stimulus 3202
          cellular response to organic substance 2418
            cellular response to topologically incorrect protein 106
              cellular response to unfolded protein 91
                endoplasmic reticulum unfolded protein response 77
                  PERK-mediated unfolded protein response 15
                    regulation of PERK-mediated unfolded protein response 8
                      negative regulation of PERK-mediated unfolded protein response 4
                      positive regulation of PERK-mediated unfolded protein response 4
paths to the root