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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of IRE1-mediated unfolded protein response
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Accession:GO:1903894 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response.
Synonyms:exact_synonym: regulation of IRE1 branch of UPR;   regulation of UPR signaling by IRE1 stress sensor;   regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling
 narrow_synonym: regulation of IRE1alpha unfolded protein response;   regulation of IRE1p unfolded protein response
 broad_synonym: regulation of IRE1 signal transduction pathway
 related_synonym: regulation of ERN1-mediated unfolded protein response;   regulation of IRE1 signaling in response to endoplasmic reticulum stress;   regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction


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regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COPS5 COP9 signalosome subunit 5 involved_in IMP (PMID:15234121) ParkinsonsUK-UCL PMID:15234121 NCBI chr 8:67,043,079...67,062,133
Ensembl chr 8:67,043,079...67,083,783
JBrowse link
G FICD FIC domain protein adenylyltransferase involved_in IDA (PMID:25601083) UniProt PMID:25601083 NCBI chr12:108,515,277...108,521,210
Ensembl chr12:108,515,277...108,525,837
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BFAR bifunctional apoptosis regulator involved_in IMP (PMID:21068390) ParkinsonsUK-UCL PMID:21068390 NCBI chr16:14,632,831...14,669,236
Ensembl chr16:14,632,931...14,669,236
JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IDA (PMID:28128204), (PMID:32160526) UniProt PMID:28128204 PMID:32160526 NCBI chr20:3,190,350...3,204,682
Ensembl chr20:3,190,350...3,204,685
JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977
JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IDA (PMID:32160526) UniProt PMID:32160526 NCBI chr 6:96,521,806...96,555,276
Ensembl chr 6:96,521,595...96,555,276
JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IDA (PMID:23220234) UniProt PMID:23220234 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433
JBrowse link
G BAK1 BCL2 antagonist/killer 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2L11 BCL2 like 11 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G DAB2IP DAB2 interacting protein involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 9:121,566,883...121,785,530
Ensembl chr 9:121,567,057...121,785,530
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
G TMEM33 transmembrane protein 33 involved_in IDA (PMID:26268696) UniProt PMID:26268696 NCBI chr 4:41,935,120...41,960,803
Ensembl chr 4:41,935,129...41,960,803
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    cellular process 17456
      signal transduction 6274
        endoplasmic reticulum unfolded protein response 81
          IRE1-mediated unfolded protein response 21
            regulation of IRE1-mediated unfolded protein response 16
              negative regulation of IRE1-mediated unfolded protein response 6
              positive regulation of IRE1-mediated unfolded protein response 8
Path 2
Term Annotations click to browse term
  biological_process 18537
    response to stimulus 9790
      response to chemical 5359
        response to organic substance 3922
          response to topologically incorrect protein 167
            response to unfolded protein 145
              cellular response to unfolded protein 105
                endoplasmic reticulum unfolded protein response 81
                  regulation of endoplasmic reticulum unfolded protein response 32
                    regulation of IRE1-mediated unfolded protein response 16
                      negative regulation of IRE1-mediated unfolded protein response 6
                      positive regulation of IRE1-mediated unfolded protein response 8
paths to the root