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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of blood circulation
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Accession:GO:1903523 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.
Synonyms:exact_synonym: down regulation of blood circulation;   downregulation of blood circulation
 narrow_synonym: inhibition of blood circulation
 related_synonym: down regulation of hemolymph circulation;   downregulation of hemolymph circulation;   inhibition of hemolymph circulation;   negative regulation of hemolymph circulation


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negative regulation of blood circulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067:PRO_0000000093|UniProtKB:P12023:PRO_0000000119|UniProtKB:P22387 (MGI:6271381|PMID:12808450)		 Ensembl
RGD		 PMID:12808450 GO_REF:0000107 MGI:6271381 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:P22387|UniProtKB:Q62151 (PMID:12808450)
UniProtKB:P22387|UniProtKB:Q62151 (MGI:6271381|PMID:12808450)		 RGD PMID:12808450 MGI:6271381 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
negative regulation of cardiac muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde5a phosphodiesterase 5A involved_in IEA
ISO		 GO_REF:0000107
(MGI:3836877|PMID:19127022)		 Ensembl
RGD		 PMID:19127022 GO_REF:0000107 MGI:3836877 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Sri sorcin involved_in ISO (MGI:5319286|PMID:22326846) RGD PMID:22326846 MGI:5319286 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO		 GO_REF:0000024
(MGI:5142149|PMID:21616078)		 UniProt
RGD		 PMID:21616078 GO_REF:0000024 MGI:5142149 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
negative regulation of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor IMP RGD PMID:16286581 RGD:1625235 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO MGI:3527337 (MGI:3525392|PMID:15485817) RGD PMID:15485817 MGI:3525392 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO MGI:2451291 (MGI:1337471|PMID:10360172) RGD PMID:10360172 MGI:1337471 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:97622 (MGI:1347184|PMID:10555147) RGD PMID:10555147 MGI:1347184 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Il2 interleukin 2 IDA in isolated ventricular myocytes RGD PMID:11907831 RGD:727354 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Jak2 Janus kinase 2 IMP IL-6 induced loss of ventricular myocyte contractility RGD PMID:12595539 RGD:1641934 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:15331368 RGD:1598375 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in ISO (MGI:5442270|PMID:21903937) RGD PMID:21903937 MGI:5442270 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pln phospholamban acts_upstream_of_or_within ISO MGI:2158357|MGI:88110 (MGI:1347184|PMID:10555147), (MGI:87597|PMID:8062415) RGD PMID:8062415 PMID:10555147 MGI:1347184 MGI:87597 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Prkca protein kinase C, alpha IMP RGD PMID:17628588 RGD:2292479 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IMP RGD PMID:19248761 RGD:7777121 NCBI chr 1:228,409,883...229,638,794 JBrowse link
negative regulation of heart rate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (MGI:3626025|PMID:9449684) RGD PMID:9449684 MGI:3626025 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B involved_in ISO (MGI:3621834|PMID:12837242) RGD PMID:12837242 MGI:3621834 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Gjd3 gap junction protein, delta 3 involved_in ISO (MGI:3623651|PMID:16571663) RGD PMID:16571663 MGI:3623651 NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:8680863 RGD:2316573 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP RGD PMID:19015400 RGD:4108483 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pln phospholamban involved_in ISO
IBA		 (PMID:16432188)
PMID:21873635		 RGD PMID:16432188 PMID:21873635 RGD:13792537 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Rnls renalase, FAD-dependent amine oxidase involved_in ISO (PMID:15841207) RGD PMID:15841207 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823 		JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 acts_upstream_of_or_within ISO MGI:1856134 (MGI:4837024|PMID:20877009) RGD PMID:20877009 MGI:4837024 NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228 		JBrowse link
G Spx spexin hormone involved_in IDA PMID:22038051 UniProt PMID:22038051 RGD:8693358 NCBI chr 4:175,356,044...175,362,082
Ensembl chr 4:175,356,247...175,362,082 		JBrowse link
G Sri sorcin involved_in ISO (PMID:12754254) RGD PMID:12754254 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:7875478 RGD:14975128 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:27335281 RGD:13792700 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:12217424 RGD:2306871 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
negative regulation of heart rate by acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:9316844 RGD:2303391 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A acts_upstream_of_or_within ISO MGI:2387663 (MGI:2182494|PMID:12093905) RGD PMID:12093905 MGI:2182494 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
negative regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO
IEA		 (PMID:15051637)
GO_REF:0000107		 RGD
Ensembl		 PMID:15051637 GO_REF:0000107 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D acts_upstream_of_or_within ISO (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
negative regulation of ventricular cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5583915|PMID:24836577)		 Ensembl
RGD		 PMID:24836577 GO_REF:0000107 MGI:5583915 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    negative regulation of biological process 5677
      negative regulation of multicellular organismal process 1145
        negative regulation of blood circulation 33
          negative regulation of cerebral blood circulation 0
          negative regulation of gastric mucosal blood circulation 0
          negative regulation of heart contraction + 31
Path 2
Term Annotations click to browse term
  biological_process 19497
    multicellular organismal process 8976
      system process 3391
        circulatory system process 589
          blood circulation 560
            regulation of blood circulation 279
              negative regulation of blood circulation 33
                negative regulation of cerebral blood circulation 0
                negative regulation of gastric mucosal blood circulation 0
                negative regulation of heart contraction + 31
paths to the root