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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of blood circulation
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Accession:GO:1903523 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.
Synonyms:exact_synonym: down regulation of blood circulation;   downregulation of blood circulation
 narrow_synonym: inhibition of blood circulation
 related_synonym: down regulation of hemolymph circulation;   downregulation of hemolymph circulation;   inhibition of hemolymph circulation;   negative regulation of hemolymph circulation

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negative regulation of blood circulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEA
ISO		 GO_REF:0000107
UniProtKB:P05067:PRO_0000000093|UniProtKB:P12023:PRO_0000000119|UniProtKB:P22387 (MGI:6271381|PMID:12808450)		 Ensembl
RGD		 PMID:12808450 GO_REF:0000107 MGI:6271381 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:P22387|UniProtKB:Q62151 (PMID:12808450)
UniProtKB:P22387|UniProtKB:Q62151 (MGI:6271381|PMID:12808450)		 RGD PMID:12808450 MGI:6271381 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
negative regulation of cardiac muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde5a phosphodiesterase 5A IEA
ISO		 GO_REF:0000107
(MGI:3836877|PMID:19127022)		 Ensembl
RGD		 PMID:19127022 GO_REF:0000107 MGI:3836877 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Sri sorcin ISO (MGI:5319286|PMID:22326846) RGD PMID:22326846 MGI:5319286 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISS
ISO		 GO_REF:0000024
(MGI:5142149|PMID:21616078)		 UniProt
RGD		 PMID:21616078 GO_REF:0000024 MGI:5142149 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165 		JBrowse link
negative regulation of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor IMP RGD PMID:16286581 RGD:1625235 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO MGI:3527337 (MGI:3525392|PMID:15485817) RGD PMID:15485817 MGI:3525392 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO MGI:2451291 (MGI:1337471|PMID:10360172) RGD PMID:10360172 MGI:1337471 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO MGI:97622 (MGI:1347184|PMID:10555147) RGD PMID:10555147 MGI:1347184 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Il2 interleukin 2 IDA in isolated ventricular myocytes RGD PMID:11907831 RGD:727354 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Jak2 Janus kinase 2 IMP IL-6 induced loss of ventricular myocyte contractility RGD PMID:12595539 RGD:1641934 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:15331368 RGD:1598375 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Pde4d phosphodiesterase 4D ISO (MGI:5442270|PMID:21903937) RGD PMID:21903937 MGI:5442270 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264 		JBrowse link
G Pln phospholamban ISO MGI:2158357|MGI:88110 (MGI:1347184|PMID:10555147), (MGI:87597|PMID:8062415) RGD PMID:8062415 PMID:10555147 MGI:1347184 MGI:87597 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904 		JBrowse link
G Prkca protein kinase C, alpha IMP RGD PMID:17628588 RGD:2292479 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IMP RGD PMID:19248761 RGD:7777121 NCBI chr 1:248,982,039...250,300,952 JBrowse link
negative regulation of heart rate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 ISO (MGI:3626025|PMID:9449684) RGD PMID:9449684 MGI:3626025 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (MGI:3621834|PMID:12837242) RGD PMID:12837242 MGI:3621834 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451 		JBrowse link
G Gjd3 gap junction protein, delta 3 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:86,888,982...86,891,915
Ensembl chr10:86,889,421...86,890,257 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:8680863 RGD:2316573 NCBI chr 7:144,127,084...144,127,873
Ensembl chr 7:144,127,085...144,127,873 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP RGD PMID:19015400 RGD:4108483 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Pln phospholamban involved_in ISO (PMID:16432188) RGD PMID:16432188 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904 		JBrowse link
G Rnls renalase, FAD-dependent amine oxidase involved_in ISO (PMID:15841207) RGD PMID:15841207 NCBI chr 1:251,828,285...252,101,963
Ensembl chr 1:251,828,290...252,100,759 		JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 ISO MGI:1856134 (MGI:4837024|PMID:20877009) RGD PMID:20877009 MGI:4837024 NCBI chr 1:84,168,494...84,254,679
Ensembl chr 1:84,168,495...84,254,645 		JBrowse link
G Spx spexin hormone involved_in IDA PMID:22038051 UniProt PMID:22038051, PMID:22038051 RGD:8693358, RGD:8693358 NCBI chr 4:176,629,597...176,635,698
Ensembl chr 4:176,629,800...176,641,008 		JBrowse link
G Sri sorcin involved_in ISO (PMID:12754254) RGD PMID:12754254 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:7875478 RGD:14975128 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:27335281 RGD:13792700 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:12217424 RGD:2306871 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145 		JBrowse link
negative regulation of heart rate by acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:9316844 RGD:2303391 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO MGI:2387663 (MGI:2182494|PMID:12093905) RGD PMID:12093905 MGI:2182494 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
negative regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO
IEA		 (PMID:15051637)
GO_REF:0000107		 RGD
Ensembl		 PMID:15051637 GO_REF:0000107 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328 		JBrowse link
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D ISO (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566 		JBrowse link
negative regulation of ventricular cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5583915|PMID:24836577)		 Ensembl
RGD		 PMID:24836577 GO_REF:0000107 MGI:5583915 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    negative regulation of biological process 5708
      negative regulation of multicellular organismal process 1132
        negative regulation of blood circulation 33
          negative regulation of cerebral blood circulation 0
          negative regulation of gastric mucosal blood circulation 0
          negative regulation of heart contraction + 31
Path 2
Term Annotations click to browse term
  biological_process 20078
    multicellular organismal process 9072
      system process 3458
        circulatory system process 567
          blood circulation 538
            regulation of blood circulation 270
              negative regulation of blood circulation 33
                negative regulation of cerebral blood circulation 0
                negative regulation of gastric mucosal blood circulation 0
                negative regulation of heart contraction + 31
paths to the root