regulation of blood circulation - Ontology Report

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ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	regulation of blood circulation	go back to main search page
Accession:	GO:1903522	browse the term
Definition:	Any process that modulates the frequency, rate or extent of blood circulation.
Synonyms:	related_synonym:	regulation of hemolymph circulation

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Rat (290) Mouse (286) Human (333) Chinchilla (247) Bonobo (270) Dog (284) Squirrel (262) Pig (279) Green Monkey (273) Naked Mole-rat (252) All
Genes (290)

regulation of blood circulation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Trpa1

transient receptor potential cation channel, subfamily A, member 1

IMP

RGD

PMID:22133672

RGD:10043378

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

Zmpste24

zinc metallopeptidase STE24

acts_upstream_of_or_within

ISO

MGI:2180033 (MGI:3797328|PMID:18443001)

RGD

PMID:18443001

MGI:3797328

NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110

atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(PMID:17242276), (PMID:18832177), (PMID:21859974)
(MGI:5427070|PMID:21859974)

RGD

PMID:17242276 PMID:18832177 PMID:21859974

MGI:5427070

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Kcna5

potassium voltage-gated channel subfamily A member 5

involved_in

ISO

(PMID:19343045), (PMID:23264583)

RGD

PMID:19343045 PMID:23264583

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

Kcne5

potassium voltage-gated channel subfamily E regulatory subunit 5

involved_in

ISO

(PMID:18313602)

RGD

PMID:18313602

NCBI chr X:105,930,398...105,931,013
Ensembl chr X:105,930,398...105,931,013

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

ISO

(PMID:12522251)

RGD

PMID:12522251

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

Nup155

nucleoporin 155

acts_upstream_of_or_within

ISO

MGI:3840086 (MGI:3839697|PMID:19070573)

RGD

PMID:19070573

MGI:3839697

NCBI chr 2:57,201,310...57,252,918
Ensembl chr 2:57,201,272...57,254,148

Scn3b

sodium voltage-gated channel beta subunit 3

involved_in

ISO

(PMID:21051419)

RGD

PMID:21051419

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISS
ISO

GO_REF:0000024
(PMID:18065446)

BHF-UCL
RGD

PMID:18065446

GO_REF:0000024

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

atrial cardiac muscle cell to AV node cell communication

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(MGI:2449848|PMID:12571597)

RGD

PMID:12571597

MGI:2449848

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

atrial cardiac muscle cell to AV node cell communication by electrical coupling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gja5

gap junction protein, alpha 5

involved_in

ISO
IBA

(PMID:16790700), (PMID:20606116), (PMID:23348765)
PMID:21873635
(MGI:3696497|PMID:10515563)

RGD

PMID:10515563 PMID:16790700 PMID:20606116 PMID:23348765 PMID:21873635

MGI:3696497, RGD:13792537

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

AV node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Scn10a

sodium voltage-gated channel alpha subunit 10

involved_in

ISO

(PMID:24998131)

RGD

PMID:24998131

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

Scn4b

sodium voltage-gated channel beta subunit 4

involved_in

ISO

(PMID:17592081)

RGD

PMID:17592081

NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISS
ISO

GO_REF:0000024
(PMID:18616619)

BHF-UCL
RGD

PMID:18616619

GO_REF:0000024

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

AV node cell to bundle of His cell communication

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cxadr

CXADR, Ig-like cell adhesion molecule

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3814765|PMID:18636119)

UniProt
RGD

PMID:18636119

GO_REF:0000024 MGI:3814765

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

Gja5

gap junction protein, alpha 5

acts_upstream_of_or_within

ISO

MGI:2445238 (MGI:3696497|PMID:10515563)

RGD

PMID:10515563

MGI:3696497

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISS
ISO

GO_REF:0000024
(PMID:10471492)

BHF-UCL
RGD

PMID:10471492

GO_REF:0000024

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

AV node cell to bundle of His cell communication by electrical coupling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:22247482)
(MGI:3696497|PMID:10515563)

RGD

PMID:10515563 PMID:22247482

MGI:3696497

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Gjc1

gap junction protein, gamma 1

involved_in

ISO

(MGI:5544102|PMID:22982984)

RGD

PMID:22982984

MGI:5544102

NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867

Gjd3

gap junction protein, delta 3

NOT|involved_in

ISO

(PMID:19168070)
(MGI:3623651|PMID:16571663), (MGI:5544102|PMID:22982984)

RGD

PMID:16571663 PMID:19168070 PMID:22982984

MGI:3623651 MGI:5544102

NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971

AV node cell to bundle of His cell signaling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

AV node cell-bundle of His cell adhesion involved in cell communication

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cxadr

CXADR, Ig-like cell adhesion molecule

involved_in

ISO

(MGI:3814765|PMID:18636119)

RGD

PMID:18636119

MGI:3814765

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

bundle of His cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Scn10a

sodium voltage-gated channel alpha subunit 10

involved_in

ISO

(PMID:24998131)

RGD

PMID:24998131

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISO
ISS

(PMID:18065446)
GO_REF:0000024

RGD
BHF-UCL

PMID:18065446

GO_REF:0000024

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

bundle of His cell to Purkinje myocyte communication

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Tnni3k

TNNI3 interacting kinase

involved_in

ISO
IEA
ISS

(PMID:23236294)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:23236294

GO_REF:0000024 GO_REF:0000107

NCBI chr 2:243,737,346...244,005,319
Ensembl chr 2:243,710,950...244,005,268

bundle of His cell to Purkinje myocyte communication by electrical coupling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:22247482)
(MGI:6101691|PMID:26786475)

RGD

PMID:22247482 PMID:26786475

MGI:6101691

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Tbx5

T-box transcription factor 5

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
(MGI:5449667|PMID:22728936)

Ensembl
RGD

PMID:22728936

GO_REF:0000107 MGI:5449667

NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ctnna3

catenin alpha 3

involved_in

ISO

(PMID:23136403)

RGD

PMID:23136403

NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978

Dsc2

desmocollin 2

involved_in

ISO

(PMID:23863954)

RGD

PMID:23863954

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

Dsg2

desmoglein 2

involved_in

ISO

(PMID:16505173)

RGD

PMID:16505173

NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156

Dsp

desmoplakin

involved_in

ISO

(PMID:12373648)

RGD

PMID:12373648

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

Jup

junction plakoglobin

involved_in

ISO
IEA

(PMID:17924338)
GO_REF:0000107

RGD
Ensembl

PMID:17924338

GO_REF:0000107

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

Pkp2

plakophilin 2

involved_in

ISO

(PMID:22889254)

RGD

PMID:22889254

NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730

cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abcc9

ATP binding cassette subfamily C member 9

involved_in

ISO
IEA

(PMID:24439875)
GO_REF:0000107

RGD
Ensembl

PMID:24439875

GO_REF:0000107

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

Cacna1c

calcium voltage-gated channel subunit alpha1 C

involved_in

ISO
ISS

(PMID:24728418)
GO_REF:0000024

RGD
UniProt

PMID:24728418

GO_REF:0000024

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Gja1

gap junction protein, alpha 1

acts_upstream_of_or_within

ISO

MGI:1857177 (MGI:3639795|PMID:10969038), (MGI:86953|PMID:9109444)

RGD

PMID:9109444 PMID:10969038

MGI:3639795 MGI:86953

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Gja5

gap junction protein, alpha 5

acts_upstream_of_or_within

ISO

RGD

PMID:9501069 PMID:9501070 PMID:10515563 PMID:10969038 PMID:18599871

MGI:1197846 MGI:1197847 MGI:3639795 MGI:3696497 MGI:4412358

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

ISO

(MGI:5575449|PMID:23542581)

RGD

PMID:23542581

MGI:5575449

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

Mef2a

myocyte enhancer factor 2a

involved_in

IEA
ISO

GO_REF:0000107
(MGI:2429350|PMID:12379849)

Ensembl
RGD

PMID:12379849

GO_REF:0000107 MGI:2429350

NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948

Mir208a

microRNA 208a

acts_upstream_of_or_within

ISO

MGI:4359821|MGI:4359822 (MGI:4359539|PMID:19726871)

RGD

PMID:19726871

MGI:4359539

NCBI chr15:28,425,570...28,425,652

Rbfox2

RNA binding fox-1 homolog 2

acts_upstream_of_or_within

ISO

MGI:6442563 (MGI:6402838|PMID:32109384)

RGD

PMID:32109384

MGI:6402838

NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691

Scn10a

sodium voltage-gated channel alpha subunit 10

acts_upstream_of_or_within

ISO

MGI:2180183 (MGI:4848026|PMID:20062061)

RGD

PMID:20062061

MGI:4848026

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

Scn1b

sodium voltage-gated channel beta subunit 1

involved_in

ISO

(MGI:3763979|PMID:17884088)

RGD

PMID:17884088

MGI:3763979

NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739

Scn2b

sodium voltage-gated channel beta subunit 2

acts_upstream_of_or_within_positive_effect

ISO

MGI:2451362 (MGI:6256920|PMID:27932425)

RGD

PMID:27932425

MGI:6256920

NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765

Scn3b

sodium voltage-gated channel beta subunit 3

acts_upstream_of_or_within

ISO

MGI:5294639 (MGI:5294649|PMID:19351516)

RGD

PMID:19351516

MGI:5294649

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

Slc4a3

solute carrier family 4 member 3

acts_upstream_of_or_within
involved_in

ISO
IEA

(PMID:29167417)
GO_REF:0000107

RGD
Ensembl

PMID:29167417

GO_REF:0000107

NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105

Sptbn4

spectrin, beta, non-erythrocytic 4

acts_upstream_of_or_within

ISO

MGI:1856134 (MGI:4837024|PMID:20877009)

RGD

PMID:20877009

MGI:4837024

NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228

Zmpste24

zinc metallopeptidase STE24

acts_upstream_of_or_within

ISO

MGI:2180033 (MGI:5824440|PMID:27799555)

RGD

PMID:27799555

MGI:5824440

NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110

cell communication by electrical coupling involved in cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gja5

gap junction protein, alpha 5

involved_in
acts_upstream_of_or_within

ISO

(PMID:16790700), (PMID:23348765)
MGI:2445466 (MGI:3664488|PMID:11046183)

RGD

PMID:11046183 PMID:16790700 PMID:23348765

MGI:3664488

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Slc8a1

solute carrier family 8 member A1

involved_in

IDA

PMID:21779914

BHF-UCL

PMID:21779914

RGD:8554732

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

cell communication involved in cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1c

calcium voltage-gated channel subunit alpha1 C

acts_upstream_of_or_within

ISO

(MGI:6402838|PMID:32109384)

RGD

PMID:32109384

MGI:6402838

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Gja5

gap junction protein, alpha 5

acts_upstream_of_or_within

ISO

MGI:2445238 (MGI:2445988|PMID:10747000)

RGD

PMID:10747000

MGI:2445988

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Gjd3

gap junction protein, delta 3

NOT|involved_in

ISO

(PMID:19168070)

RGD

PMID:19168070

NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971

Kcnd3

potassium voltage-gated channel subfamily D member 3

acts_upstream_of_or_within

ISO

(MGI:6402838|PMID:32109384)

RGD

PMID:32109384

MGI:6402838

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

Scn5a

sodium voltage-gated channel alpha subunit 5

acts_upstream_of_or_within

ISO

(MGI:6402838|PMID:32109384)

RGD

PMID:32109384

MGI:6402838

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

cell-cell signaling involved in cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Pkp2

plakophilin 2

involved_in

ISO
IBA

(PMID:22889254)
PMID:21873635

RGD

PMID:22889254 PMID:21873635

RGD:13792537

NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730

Tbx5

T-box transcription factor 5

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
UniProtKB:Q9JJV9 (MGI:5449667|PMID:22728936)

Ensembl
RGD

PMID:22728936

GO_REF:0000107 MGI:5449667

NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885

membrane depolarization during atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1c

calcium voltage-gated channel subunit alpha1 C

involved_in

ISO
ISS

(PMID:17224476)
GO_REF:0000024

RGD
BHF-UCL

PMID:17224476

GO_REF:0000024

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Cacnb2

calcium voltage-gated channel auxiliary subunit beta 2

involved_in

ISS
IEA
ISO

GO_REF:0000024
GO_REF:0000107
(PMID:17224476)

BHF-UCL
Ensembl
RGD

PMID:17224476

GO_REF:0000024 GO_REF:0000107

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISO
IEA

(PMID:18065446)
GO_REF:0000107

RGD
Ensembl

PMID:18065446

GO_REF:0000107

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

membrane depolarization during AV node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1c

calcium voltage-gated channel subunit alpha1 C

involved_in

ISS
ISO

GO_REF:0000024
(PMID:26253506)

BHF-UCL
RGD

PMID:26253506

GO_REF:0000024

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Cacnb2

calcium voltage-gated channel auxiliary subunit beta 2

involved_in

ISO
IEA
ISS

(PMID:17224476)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:17224476

GO_REF:0000024 GO_REF:0000107

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISO
IEA
ISS

(PMID:18616619)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:18616619

GO_REF:0000024 GO_REF:0000107

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Trpm4

transient receptor potential cation channel, subfamily M, member 4

involved_in

ISO
IEA

(PMID:27207958)
GO_REF:0000107

RGD
Ensembl

PMID:27207958

GO_REF:0000107

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

membrane depolarization during bundle of His cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna2d1

calcium voltage-gated channel auxiliary subunit alpha2delta 1

involved_in

ISO
IEA

(PMID:21383000)
GO_REF:0000107

RGD
Ensembl

PMID:21383000

GO_REF:0000107

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISO
IEA
ISS

(PMID:18065446)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:18065446

GO_REF:0000024 GO_REF:0000107

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Trpm4

transient receptor potential cation channel, subfamily M, member 4

involved_in

ISO
IEA

(PMID:27207958)
GO_REF:0000107

RGD
Ensembl

PMID:27207958

GO_REF:0000107

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

membrane depolarization during Purkinje myocyte cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Scn1b

sodium voltage-gated channel beta subunit 1

involved_in

ISO
IEA

(PMID:18464934)
GO_REF:0000107

RGD
Ensembl

PMID:18464934

GO_REF:0000107

NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISS
IEA
ISO

GO_REF:0000024
GO_REF:0000107
(PMID:22766342)

BHF-UCL
Ensembl
RGD

PMID:22766342

GO_REF:0000024 GO_REF:0000107

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Trpm4

transient receptor potential cation channel, subfamily M, member 4

involved_in

ISO
IEA

(PMID:27207958)
GO_REF:0000107

RGD
Ensembl

PMID:27207958

GO_REF:0000107

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

membrane depolarization during SA node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1d

calcium voltage-gated channel subunit alpha1 D

involved_in
acts_upstream_of_or_within

ISO
IEA

(PMID:21131953)
GO_REF:0000107
MGI:2180141 (MGI:3583874|PMID:12700358)

RGD
Ensembl

PMID:12700358 PMID:21131953

GO_REF:0000107 MGI:3583874

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

involved_in

ISO
IEA

(PMID:16407510)
GO_REF:0000107

RGD
Ensembl

PMID:16407510

GO_REF:0000107

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISS
IEA
ISO

GO_REF:0000024
GO_REF:0000107
(PMID:18616619)

BHF-UCL
Ensembl
RGD

PMID:18616619

GO_REF:0000024 GO_REF:0000107

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

membrane repolarization during atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Kcna5

potassium voltage-gated channel subfamily A member 5

involved_in

ISO

(PMID:19343045), (PMID:23264583)

RGD

PMID:19343045 PMID:23264583

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

Kcnj5

potassium inwardly-rectifying channel, subfamily J, member 5

involved_in

ISO
IEA

(PMID:20560207)
GO_REF:0000107

RGD
Ensembl

PMID:20560207

GO_REF:0000107

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

Kcnn2

potassium calcium-activated channel subfamily N member 2

involved_in

ISO

(MGI:5292192|PMID:19139040)

RGD

PMID:19139040

MGI:5292192

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

ISO
IEA

(PMID:12522251), (PMID:25786344)
GO_REF:0000107

RGD
Ensembl

PMID:12522251 PMID:25786344

GO_REF:0000107

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

membrane repolarization during bundle of His cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Kcna5

potassium voltage-gated channel subfamily A member 5

involved_in

ISO

(PMID:23264583)

RGD

PMID:23264583

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

membrane repolarization during SA node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Kcna5

potassium voltage-gated channel subfamily A member 5

involved_in

ISO

(PMID:19343045)

RGD

PMID:19343045

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

negative regulation of blood circulation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ager

advanced glycosylation end product-specific receptor

involved_in

ISO
IEA

UniProtKB:P05067-PRO_0000000093|UniProtKB:P12023-PRO_0000000119|UniProtKB:P22387 (MGI:6271381|PMID:12808450)
GO_REF:0000107

RGD
Ensembl

PMID:12808450

GO_REF:0000107 MGI:6271381

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

App

amyloid beta precursor protein

involved_in

ISO

UniProtKB:P22387|UniProtKB:Q62151 (PMID:12808450)
UniProtKB:P22387|UniProtKB:Q62151 (MGI:6271381|PMID:12808450)

RGD

PMID:12808450

MGI:6271381

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

negative regulation of cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gjd3

gap junction protein, delta 3

involved_in

ISO

(MGI:3623651|PMID:16571663)

RGD

PMID:16571663

MGI:3623651

NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971

negative regulation of cardiac muscle cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adenylate cyclase 10

RGD

NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951

negative regulation of cardiac muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Pde5a

phosphodiesterase 5A

involved_in

ISO
IEA

(MGI:3836877|PMID:19127022)
GO_REF:0000107

RGD
Ensembl

PMID:19127022

GO_REF:0000107 MGI:3836877

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

Sri

sorcin

involved_in

ISO

(MGI:5319286|PMID:22326846)

RGD

PMID:22326846

MGI:5319286

NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077

Zc3h12a

zinc finger CCCH type containing 12A

involved_in

ISS
ISO

GO_REF:0000024
(MGI:5142149|PMID:21616078)

UniProt
RGD

PMID:21616078

GO_REF:0000024 MGI:5142149

NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351

negative regulation of cell communication by electrical coupling involved in cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gjd3

gap junction protein, delta 3

NOT|involved_in

ISO

(PMID:19168070)
(MGI:3623651|PMID:16571663)

RGD

PMID:16571663 PMID:19168070

MGI:3623651

NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971

negative regulation of heart contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Atp1a1

ATPase Na+/K+ transporting subunit alpha 1

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:3527337 (MGI:3525392|PMID:15485817)
GO_REF:0000107

RGD
Ensembl

PMID:15485817

GO_REF:0000107 MGI:3525392

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

Atp1a2

ATPase Na+/K+ transporting subunit alpha 2

acts_upstream_of_or_within

ISO

MGI:2451291 (MGI:1337471|PMID:10360172)

RGD

PMID:10360172

MGI:1337471

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

Atp2a2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:97622 (MGI:1347184|PMID:10555147)
GO_REF:0000107

RGD
Ensembl

PMID:10555147

GO_REF:0000107 MGI:1347184

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

Pde4d

phosphodiesterase 4D

involved_in

ISO

(MGI:5442270|PMID:21903937)

RGD

PMID:21903937

MGI:5442270

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

Pln

phospholamban

acts_upstream_of_or_within

ISO

MGI:2158357|MGI:88110 (MGI:1347184|PMID:10555147), (MGI:87597|PMID:8062415)

RGD

PMID:8062415 PMID:10555147

MGI:1347184 MGI:87597

NCBI chr20:32,629,537...32,639,559

negative regulation of heart rate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Agtr2

angiotensin II receptor, type 2

involved_in

ISO

(MGI:3626025|PMID:9449684)

RGD

PMID:9449684

MGI:3626025

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

Fkbp1b

FKBP prolyl isomerase 1B

involved_in

ISO

(MGI:3621834|PMID:12837242)

RGD

PMID:12837242

MGI:3621834

NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653

Gjd3

gap junction protein, delta 3

involved_in

ISO

(MGI:3623651|PMID:16571663)

RGD

PMID:16571663

MGI:3623651

NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971

Npff

neuropeptide FF-amide peptide precursor

IDA

RGD

PMID:8680863

RGD:2316573

NCBI chr 7:133,654,530...133,655,319

Pik3r1

phosphoinositide-3-kinase regulatory subunit 1

IMP

RGD

PMID:19015400

RGD:4108483

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

Pln

phospholamban

involved_in

ISO
IBA

(PMID:16432188)
PMID:21873635

RGD

PMID:16432188 PMID:21873635

RGD:13792537

NCBI chr20:32,629,537...32,639,559

Rnls

renalase, FAD-dependent amine oxidase

involved_in

ISO

(PMID:15841207)

RGD

PMID:15841207

NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823

Sptbn4

spectrin, beta, non-erythrocytic 4

acts_upstream_of_or_within

ISO

MGI:1856134 (MGI:4837024|PMID:20877009)

RGD

PMID:20877009

MGI:4837024

NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228

Spx

spexin hormone

involved_in

IDA

PMID:22038051

UniProt

PMID:22038051

RGD:8693358

NCBI chr 4:175,356,044...175,362,082
Ensembl chr 4:175,356,247...175,362,082

Sri

sorcin

involved_in

ISO

(PMID:12754254)

RGD

PMID:12754254

NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077

Tac1

tachykinin, precursor 1

IDA

RGD

PMID:2471579

RGD:2305984

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

Tnf

tumor necrosis factor

IMP

RGD

PMID:7875478

RGD:14975128

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Trpv1

transient receptor potential cation channel, subfamily V, member 1

IMP

RGD

PMID:27335281

RGD:13792700

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

urotensin 2

RGD

NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237

negative regulation of heart rate by acetylcholine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Chrm3

cholinergic receptor, muscarinic 3

IMP

RGD

PMID:9316844

RGD:2303391

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adra1a

adrenoceptor alpha 1A

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:2387663 (MGI:2182494|PMID:12093905)
GO_REF:0000107

RGD
Ensembl

PMID:12093905

GO_REF:0000107 MGI:2182494

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

negative regulation of the force of heart contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Atp2b4

ATPase plasma membrane Ca2+ transporting 4

involved_in

ISO

(PMID:17242280)

RGD

PMID:17242280

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

negative regulation of the force of heart contraction by chemical signal

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Grk2

G protein-coupled receptor kinase 2

involved_in

ISO
IEA

(PMID:15051637)
GO_REF:0000107

RGD
Ensembl

PMID:15051637

GO_REF:0000107

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adra1d

adrenoceptor alpha 1D

acts_upstream_of_or_within

ISO

(MGI:2656483|PMID:12595294)

RGD

PMID:12595294

MGI:2656483

NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354

negative regulation of vascular associated smooth muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Arhgap42

Rho GTPase activating protein 42

acts_upstream_of_or_within

ISO

MGI:3871380 (MGI:5638847|PMID:24335996)

RGD

PMID:24335996

MGI:5638847

NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870

Dock4

dedicator of cytokinesis 4

involved_in

ISO

(PMID:22158624)

RGD

PMID:22158624

NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855

Dock5

dedicator of cytokinesis 5

involved_in

ISO

(PMID:22158624)

RGD

PMID:22158624

NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649

negative regulation of vasoconstriction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adm

adrenomedullin

involved_in

ISO

(PMID:11410113)

RGD

PMID:11410113

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

Ahr

aryl hydrocarbon receptor

involved_in

ISO

(MGI:3760685|PMID:14644620)

RGD

PMID:14644620

MGI:3760685

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

apelin

RGD

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

Bmpr2

bone morphogenetic protein receptor type 2

involved_in

ISO

(MGI:3799581|PMID:18552156)

RGD

PMID:18552156

MGI:3799581

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

Cx3cl1

C-X3-C motif chemokine ligand 1

IDA

RGD

PMID:19201996

RGD:4891967

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

Dusp5

dual specificity phosphatase 5

IMP

RGD

PMID:25397684

RGD:13446412

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

Hif1a

hypoxia inducible factor 1 subunit alpha

IMP

RGD

PMID:21106323

RGD:5147878

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hspa1a

heat shock protein family A (Hsp70) member 1A

IMP

regulates cerebral vasospasm following subarachnoid hemorrhage

RGD

PMID:15381648

RGD:1626660

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

Itga4

integrin subunit alpha 4

involved_in

IEA
ISO

GO_REF:0000107
(PMID:35802072)

Ensembl
RGD

PMID:35802072

GO_REF:0000107

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

Itga9

integrin subunit alpha 9

involved_in

ISO

(PMID:35802072)

RGD

PMID:35802072

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

Itgb1

integrin subunit beta 1

involved_in

ISS
ISO

GO_REF:0000024
(PMID:35802072)

UniProt
RGD

PMID:35802072

GO_REF:0000024

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

leptin

RGD

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

Mmp2

matrix metallopeptidase 2

IDA

RGD

PMID:19482300

RGD:2325737

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

Mtnr1b

melatonin receptor 1B

IMP

RGD

PMID:10199853

RGD:9588661

NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737

Nos1

nitric oxide synthase 1

IMP

RGD

PMID:23640592

RGD:7257607

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

Svep1

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

involved_in

ISS
ISO
IEA

GO_REF:0000024
(PMID:35802072)
GO_REF:0000107

UniProt
RGD
Ensembl

PMID:35802072

GO_REF:0000024 GO_REF:0000107

NCBI chr 5:72,811,200...72,988,185
Ensembl chr 5:72,811,410...72,988,525

negative regulation of ventricular cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bin1

bridging integrator 1

involved_in

IEA
ISO

GO_REF:0000107
(MGI:5583915|PMID:24836577)

Ensembl
RGD

PMID:24836577

GO_REF:0000107 MGI:5583915

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

positive regulation of atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Trpm4

transient receptor potential cation channel, subfamily M, member 4

IMP

RGD

PMID:23954346

RGD:10003031

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

positive regulation of cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Tbx5

T-box transcription factor 5

involved_in
acts_upstream_of

IEA
ISO

GO_REF:0000107
(MGI:5449667|PMID:22728936)

Ensembl
RGD

PMID:22728936

GO_REF:0000107 MGI:5449667

NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885

positive regulation of cardiac muscle cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Atp2a1

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

involved_in

ISS

GO_REF:0000024

UniProt

GO_REF:0000024

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

Cacna1h

calcium voltage-gated channel subunit alpha1 H

IMP

RGD

PMID:19443576

RGD:7205486

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

Strit1

small transmembrane regulator of ion transport 1

involved_in

ISO

(MGI:6304509|PMID:30299255)

RGD

PMID:30299255

MGI:6304509

NCBI chr 2:147,935,219...147,938,083
Ensembl chr 2:147,935,222...147,938,083

positive regulation of cardiac muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ace2

angiotensin I converting enzyme 2

involved_in

IEA
ISO

GO_REF:0000107
(MGI:2181229|PMID:12075344)

Ensembl
RGD

PMID:12075344

GO_REF:0000107 MGI:2181229

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

Adra1a

adrenoceptor alpha 1A

involved_in

IMP

PMID:19011682

BHF-UCL

PMID:19011682

RGD:5688340

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

Ccn2

cellular communication network factor 2

IMP

RGD

PMID:19707545

RGD:2314476

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

Chga

chromogranin A

involved_in

IDA

PMID:22459152

UniProt

PMID:22459152

RGD:6906968

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

Hsp90aa1

heat shock protein 90 alpha family class A member 1

IEP

RGD

PMID:21620734

RGD:5686387

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

IEA
ISO

GO_REF:0000107
(PMID:19646991)

Ensembl
RGD

PMID:19646991

GO_REF:0000107

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

Nppa

natriuretic peptide A

involved_in

ISO
IEA

(PMID:19646991)
GO_REF:0000107

RGD
Ensembl

PMID:19646991

GO_REF:0000107

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

Rgs2

regulator of G-protein signaling 2

involved_in

ISO

(MGI:3836877|PMID:19127022), (MGI:5009116|PMID:21291891)

RGD

PMID:19127022 PMID:21291891

MGI:3836877 MGI:5009116

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

Smtn

smoothelin

acts_upstream_of_or_within

ISO

MGI:3613292|MGI:3613293 (MGI:4437553|PMID:18678771)

RGD

PMID:18678771

MGI:4437553

NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886

urocortin

RGD

NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950

positive regulation of cell communication by electrical coupling involved in cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Trdn

triadin

involved_in

ISO

(PMID:15731460)

RGD

PMID:15731460

NCBI chr 1:23,955,651...24,410,494
Ensembl chr 1:23,955,651...24,410,595

positive regulation of cerebral blood circulation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Dusp5

dual specificity phosphatase 5

IMP

RGD

PMID:25397684

RGD:13446412

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

positive regulation of gastric mucosal blood circulation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ghrl

ghrelin and obestatin prepropeptide

IDA

RGD

PMID:17033095

RGD:12910734

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

Ptger2

prostaglandin E receptor 2

IDA

RGD

PMID:10807413

RGD:10043357

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

Ptger3

prostaglandin E receptor 3

IMP

RGD

PMID:10807413

RGD:10043357

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

positive regulation of heart contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Apela

apelin receptor early endogenous ligand

involved_in

IMP

PMID:26611206

UniProt

PMID:26611206

RGD:11534624

NCBI chr16:24,694,356...24,703,466
Ensembl chr16:24,694,324...24,703,465

Apln

apelin

involved_in

IMP

PMID:26611206

UniProt

PMID:26611206

RGD:11534624

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

Atp1a1

ATPase Na+/K+ transporting subunit alpha 1

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:2451290 (MGI:1337471|PMID:10360172)
GO_REF:0000107

RGD
Ensembl

PMID:10360172

GO_REF:0000107 MGI:1337471

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

Gsk3a

glycogen synthase kinase 3 alpha

involved_in

ISO
IEA

(MGI:4829580|PMID:20516643)
GO_REF:0000107

RGD
Ensembl

PMID:20516643

GO_REF:0000107 MGI:4829580

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

Hrc

histidine rich calcium binding protein

involved_in

ISO

UniProtKB:B9EIW1 (PMID:24125847)

RGD

PMID:24125847

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

Nkx2-5

NK2 homeobox 5

involved_in

IEA
ISO

GO_REF:0000107
(MGI:3829107|PMID:18689573)

Ensembl
RGD

PMID:18689573

GO_REF:0000107 MGI:3829107

NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934

Tgfb2

transforming growth factor, beta 2

involved_in

ISS
ISO

GO_REF:0000024
(PMID:15896309)

AgBase
RGD

PMID:15896309

GO_REF:0000024

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

positive regulation of heart rate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ada

adenosine deaminase

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:1857117|MGI:2681791 (MGI:3653129|PMID:16626672)
GO_REF:0000107

RGD
Ensembl

PMID:16626672

GO_REF:0000107 MGI:3653129

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

Adm

adrenomedullin

involved_in

IDA
IBA
ISO

PMID:21873635
(PMID:18434369)

RGD

PMID:18434369 PMID:19520650 PMID:21873635

RGD:2325635, RGD:13792537

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

Adm2

adrenomedullin 2

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331

Adra1a

adrenoceptor alpha 1A

IMP

RGD

PMID:22040923

RGD:5688308

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

adrenoceptor beta 1

RGD

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

apelin

RGD

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

Atp5pf

ATP synthase peripheral stalk subunit F6

IDA

RGD

PMID:12686462

RGD:13800918

NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119

Avpr1a

arginine vasopressin receptor 1A

IMP

RGD

PMID:18339407

RGD:2300339

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

Crhr2

corticotropin releasing hormone receptor 2

IMP

RGD

PMID:20060787

RGD:5130949

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

Edn1

endothelin 1

involved_in

ISO

(PMID:2649896)

RGD

PMID:2649896

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

Edn2

endothelin 2

involved_in

IEA
ISO

GO_REF:0000107
(PMID:2649896)

Ensembl
RGD

PMID:2649896

GO_REF:0000107

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

Edn3

endothelin 3

involved_in

ISO

(PMID:2649896)

RGD

PMID:2649896

NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093

Gch1

GTP cyclohydrolase 1

involved_in

ISO

(MGI:5629781|PMID:25557619)

RGD

PMID:25557619

MGI:5629781

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

Hey2

hes-related family bHLH transcription factor with YRPW motif 2

acts_upstream_of_or_within

ISO

MGI:3574394 (MGI:3574376|PMID:15297376)

RGD

PMID:15297376

MGI:3574376

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

Hrc

histidine rich calcium binding protein

involved_in

ISO

UniProtKB:B9EIW1 (PMID:24125847)

RGD

PMID:24125847

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

ISO
IEA

(PMID:19646991)
GO_REF:0000107

RGD
Ensembl

PMID:19646991

GO_REF:0000107

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

Nmu

neuromedin U

involved_in

IDA

PMID:11853869

UniProt

PMID:11853869

RGD:13461753

NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192

Nppa

natriuretic peptide A

involved_in

ISO
IEA

(PMID:19646991)
GO_REF:0000107

RGD
Ensembl

PMID:19646991

GO_REF:0000107

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

Pde4d

phosphodiesterase 4D

involved_in

IMP

PMID:19801680

BHF-UCL

PMID:19801680

RGD:7327160

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

Rgs4

regulator of G-protein signaling 4

IMP

RGD

PMID:25844489

RGD:13524517

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

Ryr2

ryanodine receptor 2

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:2183509|MGI:3713774 (MGI:2182484|PMID:12089338), (MGI:3713015|PMID:17431507)

Ensembl
RGD

PMID:12089338 PMID:17431507

GO_REF:0000107 MGI:2182484 MGI:3713015

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Scn3b

sodium voltage-gated channel beta subunit 3

involved_in

ISO

(MGI:5294533|PMID:19796257)

RGD

PMID:19796257

MGI:5294533

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

Scn5a

sodium voltage-gated channel alpha subunit 5

IMP

RGD

PMID:17259145

RGD:6484226

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

sirtuin 1

RGD

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

Slc1a1

solute carrier family 1 member 1

involved_in

ISO

(MGI:5584094|PMID:23361868)

RGD

PMID:23361868

MGI:5584094

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

Tacr3

tachykinin receptor 3

IDA

RGD

PMID:2471579

RGD:2305984

NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791

Trpm4

transient receptor potential cation channel, subfamily M, member 4

IMP

RGD

PMID:23954346

RGD:10003031

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

Uts2

urotensin 2

IDA

RGD

PMID:18597948 PMID:12217424

RGD:2306810, RGD:2306871

NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237

positive regulation of heart rate by epinephrine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Tpm1

tropomyosin 1

involved_in

ISO

(MGI:3802907|PMID:17556658)

RGD

PMID:17556658

MGI:3802907

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

positive regulation of heart rate by epinephrine-norepinephrine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adra1a

adrenoceptor alpha 1A

acts_upstream_of_or_within
involved_in

ISO
IEA
IBA

MGI:104774 (MGI:2664013|PMID:12782680)
GO_REF:0000107
PMID:21873635

RGD
Ensembl

PMID:12782680 PMID:21873635

GO_REF:0000107 MGI:2664013, RGD:13792537

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

Adra1b

adrenoceptor alpha 1B

acts_upstream_of_or_within
involved_in

ISO
IBA

MGI:104773 (MGI:2664013|PMID:12782680)
PMID:21873635

RGD

PMID:12782680 PMID:21873635

MGI:2664013, RGD:13792537

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

Adrb1

adrenoceptor beta 1

involved_in
acts_upstream_of_or_within

IEA
ISO
IBA

GO_REF:0000107
MGI:1857120 (MGI:1338641|PMID:10358009), (MGI:82113|PMID:8693001)
PMID:21873635

Ensembl
RGD

PMID:8693001 PMID:10358009 PMID:21873635

GO_REF:0000107 MGI:1338641 MGI:82113, RGD:13792537

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Chrna7

cholinergic receptor nicotinic alpha 7 subunit

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:1888407 (MGI:3531222|PMID:10942027)
GO_REF:0000107

RGD
Ensembl

PMID:10942027

GO_REF:0000107 MGI:3531222

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

positive regulation of the force of heart contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Myl2

myosin light chain 2

involved_in

ISS
ISO

GO_REF:0000024
(MGI:5688843|PMID:16908724)

UniProt
RGD

PMID:16908724

GO_REF:0000024 MGI:5688843

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

Nos1

nitric oxide synthase 1

involved_in

ISO

(MGI:3771112|PMID:17242280)

RGD

PMID:17242280

MGI:3771112

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

Ryr2

ryanodine receptor 2

involved_in

ISO
IEA

(PMID:15105296)
GO_REF:0000107

RGD
Ensembl

PMID:15105296

GO_REF:0000107

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Slc8a1

solute carrier family 8 member A1

involved_in

ISO
IEA

(PMID:15105296)
GO_REF:0000107

RGD
Ensembl

PMID:15105296

GO_REF:0000107

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

Slc9a1

solute carrier family 9 member A1

involved_in

ISO

(PMID:15105296)

RGD

PMID:15105296

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

positive regulation of the force of heart contraction by epinephrine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adrenoceptor beta 2

RGD

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

positive regulation of the force of heart contraction by epinephrine-norepinephrine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adra1a

adrenoceptor alpha 1A

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:104774 (MGI:2656483|PMID:12595294)
GO_REF:0000107

RGD
Ensembl

PMID:12595294

GO_REF:0000107 MGI:2656483

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

Adra1b

adrenoceptor alpha 1B

acts_upstream_of_or_within

ISO

MGI:104773 (MGI:2656483|PMID:12595294)

RGD

PMID:12595294

MGI:2656483

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

Adrb1

adrenoceptor beta 1

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:1857120 (MGI:82113|PMID:8693001), (MGI:84440|PMID:7761854)

Ensembl
RGD

PMID:7761854 PMID:8693001

GO_REF:0000107 MGI:82113 MGI:84440

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

positive regulation of the force of heart contraction by norepinephrine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adrenoceptor beta 1

RGD

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

positive regulation of vascular associated smooth muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Chrm3

cholinergic receptor, muscarinic 3

IMP

RGD

PMID:8428203

RGD:2303387

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

Mir21

microRNA 21

involved_in

ISO

(PMID:22158624)

RGD

PMID:22158624

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

Rhoa

ras homolog family member A

acts_upstream_of_or_within

ISO

(MGI:5638847|PMID:24335996)

RGD

PMID:24335996

MGI:5638847

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

positive regulation of vasoconstriction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abl1

ABL proto-oncogene 1, non-receptor tyrosine kinase

IMP

RGD

PMID:17615370

RGD:8693596

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

Ace

angiotensin I converting enzyme

IMP

RGD

PMID:17161436

RGD:12879819

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

adducin 3

RGD

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

Adra1a

adrenoceptor alpha 1A

involved_in

IDA
IBA
IMP

PMID:21873635
PMID:19011682

RGD
GO_Central
BHF-UCL

PMID:15877108 PMID:21873635 PMID:19011682 PMID:22040923

RGD:1625777, RGD:13792537, RGD:5688340, RGD:5688308

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

Adra1d

adrenoceptor alpha 1D

involved_in

IMP
IBA

PMID:21873635

RGD
GO_Central

PMID:17199872 PMID:21873635

RGD:5688350, RGD:13792537

NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354

Adra2c

adrenoceptor alpha 2C

IMP

RGD

PMID:20862454

RGD:6893567

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

Akt1

AKT serine/threonine kinase 1

IMP

RGD

PMID:21532183

RGD:5509096

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Alox5

arachidonate 5-lipoxygenase

IMP

RGD

PMID:16331105

RGD:1626151

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

arginine vasopressin

RGD

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

Avpr1a

arginine vasopressin receptor 1A

involved_in

IMP
IBA

PMID:21873635

RGD
GO_Central

PMID:17428891 PMID:21873635

RGD:2300345, RGD:13792537

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

Avpr1b

arginine vasopressin receptor 1B

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792

Avpr2

arginine vasopressin receptor 2

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr X:151,633,501...151,636,155
Ensembl chr X:151,633,522...151,635,989

Casr

calcium-sensing receptor

IMP

RGD

PMID:22098336

RGD:7205678

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

Cav1

caveolin 1

involved_in
acts_upstream_of_or_within

IMP
IEA
ISO

GO_REF:0000107
MGI:2180364 (MGI:2176684|PMID:11884617)

Ensembl
RGD

PMID:11884617 PMID:21098487

GO_REF:0000107 MGI:2176684, RGD:6849297

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

CD38 molecule

RGD

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

chromogranin A

RGD

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

Chrm3

cholinergic receptor, muscarinic 3

IMP

RGD

PMID:9316844

RGD:2303391

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

Cysltr1

cysteinyl leukotriene receptor 1

IMP

RGD

PMID:16445567 PMID:16331105

RGD:2316238, RGD:1626151

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

Dbh

dopamine beta-hydroxylase

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:1857556 (MGI:87391|PMID:9139828)

Ensembl
RGD

PMID:9139828

GO_REF:0000107 MGI:87391

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

Egfr

epidermal growth factor receptor

IMP

RGD

PMID:22966991

RGD:7204494

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

F2r

coagulation factor II (thrombin) receptor

involved_in

IDA
ISO
IEA

(MGI:5315674|PMID:21859963)
GO_REF:0000107

RGD
Ensembl

PMID:21859963 PMID:12644441

GO_REF:0000107 MGI:5315674, RGD:1582293

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

F2rl1

F2R like trypsin receptor 1

involved_in

ISO

(PMID:24506284)

RGD

PMID:24506284

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

Faah

fatty acid amide hydrolase

IMP

RGD

PMID:17245358

RGD:1625725

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

Fga

fibrinogen alpha chain

involved_in

ISO

(PMID:15739255)

RGD

PMID:15739255

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

Fgb

fibrinogen beta chain

involved_in

ISO

(PMID:15739255)

RGD

PMID:15739255

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

Fgg

fibrinogen gamma chain

involved_in

ISO

(PMID:15739255)

RGD

PMID:15739255

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

Gja1

gap junction protein, alpha 1

IMP

RGD

PMID:21414209

RGD:7207411

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Gja5

gap junction protein, alpha 5

IMP

RGD

PMID:21414209

RGD:7207411

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Grk2

G protein-coupled receptor kinase 2

IMP

RGD

PMID:28882814

RGD:13506839

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

Hmgcr

3-hydroxy-3-methylglutaryl-CoA reductase

IMP

RGD

PMID:19221211

RGD:2316498

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

Hrh1

histamine receptor H 1

involved_in

IMP
IEA

GO_REF:0000002

InterPro
RGD

PMID:17169617

GO_REF:0000002, RGD:1642309

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

Hrh2

histamine receptor H 2

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

Htr2a

5-hydroxytryptamine receptor 2A

IMP

RGD

PMID:16527989

RGD:1582161

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

Htr2c

5-hydroxytryptamine receptor 2C

IMP

RGD

PMID:15118345

RGD:1625008

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

Icam1

intercellular adhesion molecule 1

IMP

RGD

PMID:12296653

RGD:4145431

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Klk1c9

kallikrein 1-related peptidase C9

IDA

RGD

PMID:1900513

RGD:1302426

NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245

monoglyceride lipase

RGD

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

Mt-co1

mitochondrially encoded cytochrome c oxidase I

involved_in

ISO

(PMID:24506284)

RGD

PMID:24506284

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

Mt-co2

mitochondrially encoded cytochrome c oxidase II

involved_in

ISO

(PMID:24506284)

RGD

PMID:24506284

NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

Npy1r

neuropeptide Y receptor Y1

IMP

RGD

PMID:9802404

RGD:1642323

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

Oxtr

oxytocin receptor

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674

phosphodiesterase 5A

RGD

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

Ptger3

prostaglandin E receptor 3

IMP

RGD

PMID:10747002

RGD:10043337

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

Ptgs1

prostaglandin-endoperoxide synthase 1

IMP

RGD

PMID:17245358 PMID:18456673

RGD:1625725, RGD:2300248

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

Ptgs2

prostaglandin-endoperoxide synthase 2

IMP

RGD

PMID:17245358 PMID:18456673

RGD:1625725, RGD:2300248

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Rbfox2

RNA binding fox-1 homolog 2

IMP

RGD

PMID:28993448

RGD:329848961

NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691

Rhoa

ras homolog family member A

IEP

RGD

PMID:17468135

RGD:1642958

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Shc1

SHC adaptor protein 1

IMP

RGD

PMID:16242150

RGD:1643184

NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536

Smtnl1

smoothelin-like 1

acts_upstream_of_or_within
involved_in

ISO

MGI:3796616 (MGI:3796498|PMID:18310078)
(MGI:4844228|PMID:20634291)

RGD

PMID:18310078 PMID:20634291

MGI:3796498 MGI:4844228

NCBI chr 3:69,889,010...69,901,096
Ensembl chr 3:69,889,010...69,901,079

Tacr1

tachykinin receptor 1

IMP

RGD

PMID:18602450

RGD:2304265

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

Tbxa2r

thromboxane A2 receptor

involved_in

IMP
IBA

PMID:21873635

RGD
GO_Central

PMID:16905600 PMID:21873635 PMID:10513923

RGD:1601433, RGD:13792537, RGD:11059603

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

Tbxas1

thromboxane A synthase 1

IMP

RGD

PMID:9370383

RGD:1601472

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

Trpm4

transient receptor potential cation channel, subfamily M, member 4

IMP

RGD

PMID:20610768 PMID:15472118

RGD:9999443, RGD:10003027

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

urotensin 2 receptor

RGD

NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252

WD repeat domain 35

RGD

NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029

Purkinje myocyte to ventricular cardiac muscle cell signaling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ryr2

ryanodine receptor 2

involved_in

IEA
ISO

GO_REF:0000107
(MGI:3820489|PMID:17872467)

Ensembl
RGD

PMID:17872467

GO_REF:0000107 MGI:3820489

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

regulation of atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(PMID:12571597)
(MGI:2449848|PMID:12571597)

RGD

PMID:12571597

MGI:2449848

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:23348765)

RGD

PMID:23348765

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Ryr2

ryanodine receptor 2

involved_in

ISO
IEA

(PMID:17875969)
GO_REF:0000107

RGD
Ensembl

PMID:17875969

GO_REF:0000107

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

regulation of AV node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(MGI:2449848|PMID:12571597)

RGD

PMID:12571597

MGI:2449848

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Cxadr

CXADR, Ig-like cell adhesion molecule

involved_in

ISO

(MGI:3814765|PMID:18636119)

RGD

PMID:18636119

MGI:3814765

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:22247482)
(MGI:3696497|PMID:10515563)

RGD

PMID:10515563 PMID:22247482

MGI:3696497

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Ryr2

ryanodine receptor 2

involved_in

ISO
IEA

(PMID:17875969)
GO_REF:0000107

RGD
Ensembl

PMID:17875969

GO_REF:0000107

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

regulation of bundle of His cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:22247482)
(MGI:3696497|PMID:10515563)

RGD

PMID:10515563 PMID:22247482

MGI:3696497

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Rangrf

RAN guanine nucleotide release factor

involved_in

ISO

(PMID:21621375)

RGD

PMID:21621375

NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840

regulation of cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ace2

angiotensin I converting enzyme 2

involved_in

ISO
IEA

(PMID:12967627)
GO_REF:0000107

RGD
Ensembl

PMID:12967627

GO_REF:0000107

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

Agt

angiotensinogen

involved_in

ISO
IEA

UniProtKB:P00797 (PMID:17416596)
GO_REF:0000107

RGD
Ensembl

PMID:17416596

GO_REF:0000107

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

Ehd3

EH-domain containing 3

involved_in

IEA
ISO

GO_REF:0000107
(MGI:5770033|PMID:25825486)

Ensembl
RGD

PMID:25825486

GO_REF:0000107 MGI:5770033

NCBI chr 6:21,640,861...21,665,601
Ensembl chr 6:21,639,290...21,665,236

Mir19a

microRNA 19a

involved_in

ISO

(PMID:23271053)

RGD

PMID:23271053

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

Nkx2-5

NK2 homeobox 5

involved_in

IEA
ISO

GO_REF:0000107
(MGI:3829107|PMID:18689573)

Ensembl
RGD

PMID:18689573

GO_REF:0000107 MGI:3829107

NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934

Tmem65

transmembrane protein 65

involved_in

ISO
IBA

(MGI:5699931|PMID:26403541)
PMID:21873635

RGD

PMID:26403541 PMID:21873635

MGI:5699931, RGD:13792537

NCBI chr 7:90,336,997...90,378,930
Ensembl chr 7:90,274,142...90,379,474

Tnni3k

TNNI3 interacting kinase

involved_in

ISO
IEA
ISS

UniProtKB:Q5GIG6 (PMID:23236294)
GO_REF:0000107
(MGI:5474909|PMID:23236294)
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:23236294

GO_REF:0000024 GO_REF:0000107 MGI:5474909

NCBI chr 2:243,737,346...244,005,319
Ensembl chr 2:243,710,950...244,005,268

regulation of cardiac muscle cell action potential involved in regulation of contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akap9

A-kinase anchoring protein 9

involved_in

ISO

(PMID:18093912)

RGD

PMID:18093912

NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606

Atp2a2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

involved_in

IDA

PMID:9851937

BHF-UCL

PMID:9851937

RGD:10047146

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

Camk2d

calcium/calmodulin-dependent protein kinase II delta

involved_in

PMID:12676813

BHF-UCL

PMID:12676813

RGD:10047271

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

Cav3

caveolin 3

involved_in

ISO

(PMID:17060380)

RGD

PMID:17060380

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

Fgf13

fibroblast growth factor 13

involved_in

ISO

(MGI:5437408|PMID:21817159)

RGD

PMID:21817159

MGI:5437408

NCBI chr X:137,276,498...137,800,056
Ensembl chr X:137,276,511...137,800,391

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

involved_in

ISO
IEA

(PMID:16407510)
GO_REF:0000107

RGD
Ensembl

PMID:16407510

GO_REF:0000107

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Rangrf

RAN guanine nucleotide release factor

involved_in

ISO

(PMID:21621375)

RGD

PMID:21621375

NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840

regulation of cardiac muscle cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adora1

adenosine A1 receptor

IDA

RGD

PMID:19525381

RGD:2317914

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

Adrb1

adrenoceptor beta 1

IMP
IDA

RGD

PMID:22216755 PMID:19525381

RGD:6893639, RGD:2317914

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

Akap6

A-kinase anchoring protein 6

involved_in

IMP

PMID:11179196

BHF-UCL

PMID:11179196

RGD:8553373

NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738

Ank2

ankyrin 2

involved_in

ISO

UniProtKB:Q8C8R3 (PMID:17242276)
(MGI:3771114|PMID:17242276)

RGD

PMID:17242276

MGI:3771114

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Atp1a1

ATPase Na+/K+ transporting subunit alpha 1

IMP

RGD

PMID:15629895

RGD:6903236

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

Atp1a2

ATPase Na+/K+ transporting subunit alpha 2

IMP

RGD

PMID:17442282

RGD:6903343

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

Casq2

calsequestrin 2

involved_in

IMP

PMID:17569730

BHF-UCL

PMID:17569730

RGD:2314601

NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267

Fxyd1

FXYD domain-containing ion transport regulator 1

IMP

RGD

PMID:14684371

RGD:9685468

NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278

Gata4

GATA binding protein 4

IMP

RGD

PMID:21702924

RGD:7207043

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

Kcnj2

potassium inwardly-rectifying channel, subfamily J, member 2

IMP

RGD

PMID:22426100

RGD:7247430

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

Myh7b

myosin heavy chain 7B

IMP

RGD

PMID:32207065

RGD:126925946

NCBI chr 3:144,076,911...144,122,714
Ensembl chr 3:144,098,190...144,122,084

Pde4b

phosphodiesterase 4B

involved_in

ISO
IEA

(MGI:5286798|PMID:21670503)
GO_REF:0000107

RGD
Ensembl

PMID:21670503

GO_REF:0000107 MGI:5286798

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

Pde4d

phosphodiesterase 4D

involved_in

IMP
ISO
IBA

(MGI:5286798|PMID:21670503), (MGI:5442270|PMID:21903937)
PMID:21873635
PMID:19801680

RGD

PMID:21670503 PMID:21903937 PMID:19801680 PMID:21873635 PMID:19801680

MGI:5286798 MGI:5442270, RGD:7327160, RGD:13792537, RGD:7327160

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

Pln

phospholamban

acts_upstream_of_or_within

ISO

MGI:2158357 (MGI:3655311|PMID:8620604)

RGD

PMID:8620604

MGI:3655311

NCBI chr20:32,629,537...32,639,559

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in
acts_upstream_of_or_within

ISO
ISS
IEA

(PMID:22529811)
GO_REF:0000024
GO_REF:0000107
MGI:2179753 (MGI:3695100|PMID:16172272)

RGD
BHF-UCL
Ensembl

PMID:16172272 PMID:22529811

GO_REF:0000024 GO_REF:0000107 MGI:3695100

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Sri

sorcin

involved_in

ISO

(PMID:12754254), (PMID:17130302)

RGD

PMID:12754254 PMID:17130302

NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077

Stc1

stanniocalcin 1

involved_in

ISO

(PMID:12663264)

RGD

PMID:12663264

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

Sumo1

small ubiquitin-like modifier 1

involved_in

ISO

(MGI:5292424|PMID:21900893)

RGD

PMID:21900893

MGI:5292424

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

regulation of cardiac muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adora1

adenosine A1 receptor

IMP

RGD

PMID:20334814

RGD:2317910

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

Adra1a

adrenoceptor alpha 1A

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

Adra1b

adrenoceptor alpha 1B

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

Agrn

agrin

involved_in

ISO

(MGI:4352602|PMID:19376779)

RGD

PMID:19376779

MGI:4352602

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

Ank2

ankyrin 2

involved_in

ISO

(PMID:15178757)
(MGI:3044878|PMID:15178757)

RGD

PMID:15178757

MGI:3044878

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Asb15

ankyrin repeat and SOCS box containing 15

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr 4:53,021,553...53,050,846
Ensembl chr 4:53,031,692...53,049,928

Bmp10

bone morphogenetic protein 10

involved_in

ISO
IEA

(PMID:17921333)
GO_REF:0000107

RGD
Ensembl

PMID:17921333

GO_REF:0000107

NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627

Calm1

calmodulin 1

involved_in

ISO
IEA

(PMID:23040497)
GO_REF:0000107

RGD
Ensembl

PMID:23040497

GO_REF:0000107

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

Calm2

calmodulin 2

involved_in

ISO

(PMID:23040497)

RGD

PMID:23040497

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

Calm3

calmodulin 3

involved_in

ISO

(PMID:23040497)

RGD

PMID:23040497

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

Cav3

caveolin 3

involved_in

ISO

(PMID:17275750)

RGD

PMID:17275750

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

Ehd3

EH-domain containing 3

involved_in

IEA
ISO

GO_REF:0000107
(MGI:5770033|PMID:25825486)

Ensembl
RGD

PMID:25825486

GO_REF:0000107 MGI:5770033

NCBI chr 6:21,640,861...21,665,601
Ensembl chr 6:21,639,290...21,665,236

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:16790700), (PMID:22247482), (PMID:23348765)

RGD

PMID:16790700 PMID:22247482 PMID:23348765

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

involved_in

ISO

(PMID:12750403)

RGD

PMID:12750403

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Mir1

microRNA 1

involved_in

ISO

(PMID:19131648)

RGD

PMID:19131648

NCBI chr18:1,887,537...1,887,623

Mir1b

microRNA 1b

involved_in

ISO

(PMID:19131648)

RGD

PMID:19131648

NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201

Mir200c

microRNA 200c

acts_upstream_of

ISO

(PMID:29373717)

RGD

PMID:29373717

NCBI chr 4:157,523,679...157,523,747

Nkx2-5

NK2 homeobox 5

involved_in

IEA
ISO

GO_REF:0000107
(MGI:3829107|PMID:18689573)

Ensembl
RGD

PMID:18689573

GO_REF:0000107 MGI:3829107

NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934

P2rx4

purinergic receptor P2X 4

involved_in

ISO

(PMID:11606481), (PMID:15130891)

RGD

PMID:11606481 PMID:15130891

NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253

Rnf207

ring finger protein 207

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375

Ryr2

ryanodine receptor 2

involved_in

ISO

(PMID:11159936)

RGD

PMID:11159936

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Scn10a

sodium voltage-gated channel alpha subunit 10

involved_in

ISO

(PMID:20062061)

RGD

PMID:20062061

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

Smad7

SMAD family member 7

involved_in

IEA
ISO

GO_REF:0000107
(MGI:3836072|PMID:18952608)

Ensembl
RGD

PMID:18952608

GO_REF:0000107 MGI:3836072

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

Tnni3k

TNNI3 interacting kinase

involved_in

ISO
IEA
ISS

(PMID:24925317)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:24925317

GO_REF:0000024 GO_REF:0000107

NCBI chr 2:243,737,346...244,005,319
Ensembl chr 2:243,710,950...244,005,268

regulation of cardiac muscle contraction by calcium ion signaling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(PMID:12571597)
(MGI:2449848|PMID:12571597)

RGD

PMID:12571597

MGI:2449848

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Atp1a2

ATPase Na+/K+ transporting subunit alpha 2

involved_in

PMID:17442282

BHF-UCL

PMID:17442282

RGD:6903343

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

Atp1b1

ATPase Na+/K+ transporting subunit beta 1

involved_in

ISO
IEA

(MGI:4359299|PMID:19683723)
GO_REF:0000107

RGD
Ensembl

PMID:19683723

GO_REF:0000107 MGI:4359299

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

Atp2a2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

involved_in

ISO
IBA
IDA

(PMID:10587333)
PMID:21873635
PMID:9851937

RGD

PMID:10587333 PMID:21873635 PMID:9851937

RGD:13792537, RGD:10047146

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

Hdac4

histone deacetylase 4

acts_upstream_of_or_within
involved_in

ISO
IEA

(MGI:3793386|PMID:18250163)
GO_REF:0000107

RGD
Ensembl

PMID:18250163

GO_REF:0000107 MGI:3793386

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

Ryr2

ryanodine receptor 2

involved_in

ISO

(PMID:17875969)

RGD

PMID:17875969

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Slc9a1

solute carrier family 9 member A1

involved_in

ISO

(PMID:15105296)

RGD

PMID:15105296

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

Tnni3

troponin I3, cardiac type

involved_in

ISO

(PMID:25771144)

RGD

PMID:25771144

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

UniProtKB:Q8C8R3 (PMID:17178715)
(MGI:5427070|PMID:21859974), (MGI:5430893|PMID:17178715)

RGD

PMID:17178715 PMID:21859974

MGI:5427070 MGI:5430893

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Cacna1c

calcium voltage-gated channel subunit alpha1 C

involved_in

ISS

GO_REF:0000024

UniProt

GO_REF:0000024

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Camk2d

calcium/calmodulin-dependent protein kinase II delta

involved_in

PMID:12676813

BHF-UCL

PMID:12676813

RGD:10047271

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

Casq2

calsequestrin 2

involved_in
acts_upstream_of_or_within

IBA
IEA
ISO
IMP

PMID:21873635
GO_REF:0000107
(MGI:1202079|PMID:9525981)
(MGI:3689635|PMID:16932808)
PMID:17569730
(PMID:16601229), (PMID:16908766)

Ensembl
RGD

PMID:9525981 PMID:16601229 PMID:16908766 PMID:16932808 PMID:21873635 More...

GO_REF:0000107 MGI:1202079 MGI:3689635, RGD:13792537, RGD:2314601

NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267

Dmd

dystrophin

involved_in

ISO

(MGI:4420848|PMID:20080623)

RGD

PMID:20080623

MGI:4420848

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

Fkbp1b

FKBP prolyl isomerase 1B

involved_in

IBA
ISO

PMID:21873635
(MGI:3621834|PMID:12837242)

RGD

PMID:12837242 PMID:21873635

MGI:3621834, RGD:13792537

NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653

Pln

phospholamban

acts_upstream_of_or_within

ISO

MGI:2158357 (MGI:82999|PMID:8831698)

RGD

PMID:8831698

MGI:82999

NCBI chr20:32,629,537...32,639,559

Ryr2

ryanodine receptor 2

involved_in

IEA
ISO

GO_REF:0000107
UniProtKB:Q9Z2I2 (MGI:3621834|PMID:12837242)

Ensembl
RGD

PMID:12837242

GO_REF:0000107 MGI:3621834

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Slc8a1

solute carrier family 8 member A1

involved_in

IDA

PMID:21779914

BHF-UCL

PMID:21779914

RGD:8554732

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

Tmem38a

transmembrane protein 38a

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:1098718 (MGI:3715564|PMID:17611541)

Ensembl
RGD

PMID:17611541

GO_REF:0000107 MGI:3715564

NCBI chr16:17,258,160...17,274,204
Ensembl chr16:17,258,164...17,273,415

Tmem38b

transmembrane protein 38B

acts_upstream_of_or_within

ISO

MGI:1921416 (MGI:3715564|PMID:17611541)

RGD

PMID:17611541

MGI:3715564

NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025

regulation of cell communication by electrical coupling involved in cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Camk2d

calcium/calmodulin-dependent protein kinase II delta

involved_in

PMID:12676813

BHF-UCL

PMID:12676813

RGD:10047271

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

Cav1

caveolin 1

involved_in

ISO
IEA

(MGI:5607357|PMID:25017399)
GO_REF:0000107

RGD
Ensembl

PMID:25017399

GO_REF:0000107 MGI:5607357

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Hrc

histidine rich calcium binding protein

involved_in

ISO

UniProtKB:B9EIW1 (PMID:24125847)

RGD

PMID:24125847

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

Irx3

iroquois homeobox 3

acts_upstream_of

ISO

(MGI:5288100|PMID:21825130)

RGD

PMID:21825130

MGI:5288100

NCBI chr19:15,211,882...15,215,317
Ensembl chr19:15,211,878...15,215,317

Pde4d

phosphodiesterase 4D

involved_in

IEA
ISO

GO_REF:0000107
(PMID:16213210)

Ensembl
RGD

PMID:16213210

GO_REF:0000107

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

Sri

sorcin

involved_in

ISO

(PMID:17130302)

RGD

PMID:17130302

NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077

regulation of heart contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1b

calcium voltage-gated channel subunit alpha1 B

acts_upstream_of_or_within

ISO

MGI:2180187 (MGI:2179540|PMID:11296258)

RGD

PMID:11296258

MGI:2179540

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

Chrm2

cholinergic receptor, muscarinic 2

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

Dmpk

DM1 protein kinase

involved_in

IBA
ISO

PMID:21873635
(MGI:3575053|PMID:15598648)
(PMID:15598648)

RGD

PMID:15598648 PMID:21873635

MGI:3575053, RGD:13792537

NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593

Gja1

gap junction protein, alpha 1

acts_upstream_of_or_within

ISO

MGI:1857177|MGI:2386742|MGI:3051881 (MGI:2157676|PMID:11397787), (MGI:3051209|PMID:11179202)

RGD

PMID:11179202 PMID:11397787

MGI:2157676 MGI:3051209

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Glp1r

glucagon-like peptide 1 receptor

involved_in

IEA
ISO

GO_REF:0000107
(MGI:2663341|PMID:12746281)

Ensembl
RGD

PMID:12746281

GO_REF:0000107 MGI:2663341

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

Gnai2

G protein subunit alpha i2

NOT|acts_upstream_of_or_within

ISO

MGI:2152618 (MGI:1931975|PMID:11158953)

RGD

PMID:11158953

MGI:1931975

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

Gnai3

G protein subunit alpha i3

NOT|acts_upstream_of_or_within

ISO

MGI:2152617 (MGI:1931975|PMID:11158953)

RGD

PMID:11158953

MGI:1931975

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

Gnao1

G protein subunit alpha o1

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:2152683 (MGI:86399|PMID:9050846)
GO_REF:0000107

RGD
Ensembl

PMID:9050846

GO_REF:0000107 MGI:86399

NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493

Hbegf

heparin-binding EGF-like growth factor

acts_upstream_of_or_within

ISO

MGI:2655703 (MGI:2654964|PMID:12621152)

RGD

PMID:12621152

MGI:2654964

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

acts_upstream_of_or_within

ISO

MGI:2684538 (MGI:2682533|PMID:14657344)

RGD

PMID:14657344

MGI:2682533

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Hopx

HOP homeobox

acts_upstream_of_or_within

ISO

MGI:2389244 (MGI:3624209|PMID:15790958)

RGD

PMID:15790958

MGI:3624209

NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909

Hrc

histidine rich calcium binding protein

acts_upstream_of_or_within

ISO

(MGI:3625212|PMID:16600288)

RGD

PMID:16600288

MGI:3625212

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

Kcne5

potassium voltage-gated channel subfamily E regulatory subunit 5

involved_in

ISO

(PMID:18313602)

RGD

PMID:18313602

NCBI chr X:105,930,398...105,931,013
Ensembl chr X:105,930,398...105,931,013

Mir92a2

microRNA 92a-2

involved_in

ISO

(PMID:23897866)

RGD

PMID:23897866

NCBI chr X:132,421,942...132,422,033
Ensembl chr X:132,421,942...132,422,033

Mybpc3

myosin binding protein C3

acts_upstream_of_or_within

ISO

MGI:2654420|MGI:3526881 (MGI:3580188|PMID:15059932), (MGI:3607201|PMID:15472117), (MGI:3628863|PMID:14500336)

RGD

PMID:14500336 PMID:15059932 PMID:15472117

MGI:3580188 MGI:3607201 MGI:3628863

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

Myh6

myosin heavy chain 6

acts_upstream_of_or_within

ISO

RGD

PMID:8614836 PMID:8878443 PMID:9045856 PMID:9884344 PMID:10066683 More...

MGI:1327483 MGI:1332374 MGI:1333559 MGI:1344104 MGI:3664144 MGI:80448 MGI:83539

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

Pln

phospholamban

involved_in
acts_upstream_of_or_within

ISO

(PMID:16432188)
MGI:2158357 (MGI:82999|PMID:8831698)

RGD

PMID:8831698 PMID:16432188

MGI:82999

NCBI chr20:32,629,537...32,639,559

S100a1

S100 calcium binding protein A1

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544

Sp4

Sp4 transcription factor

acts_upstream_of_or_within

ISO

MGI:2676622 (MGI:2181501|PMID:11007485)

RGD

PMID:11007485

MGI:2181501

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

tyrosine hydroxylase

acts_upstream_of_or_within

ISO

MGI:1860450|MGI:1860453 (MGI:72094|PMID:7715703), (MGI:77787|PMID:7592982)

RGD

PMID:7592982 PMID:7715703

MGI:72094 MGI:77787

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

Thra

thyroid hormone receptor alpha

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:1860441|MGI:2183135 (MGI:1195830|PMID:9430637), (MGI:3047216|PMID:15240882)

Ensembl
RGD

PMID:9430637 PMID:15240882

GO_REF:0000107 MGI:1195830 MGI:3047216

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

Thrb

thyroid hormone receptor beta

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
(MGI:1316795|PMID:9832432)

Ensembl
RGD

PMID:9832432

GO_REF:0000107 MGI:1316795

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

Tnnt2

troponin T2, cardiac type

involved_in
acts_upstream_of_or_within

ISS
IEA
ISO

GO_REF:0000024
GO_REF:0000107
MGI:3692450|MGI:3693250 (MGI:1931973|PMID:11158969), (MGI:3611718|PMID:16326803)
(PMID:15542288)

UniProt
Ensembl
RGD

PMID:11158969 PMID:15542288 PMID:16326803

GO_REF:0000024 GO_REF:0000107 MGI:1931973 MGI:3611718

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

Zmpste24

zinc metallopeptidase STE24

acts_upstream_of_or_within

ISO

MGI:2180033 (MGI:5824440|PMID:27799555)

RGD

PMID:27799555

MGI:5824440

NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110

regulation of heart rate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

RGD

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

Ank2

ankyrin 2

involved_in

ISO

(PMID:18832177)
(MGI:5430886|PMID:18832177)

RGD

PMID:18832177

MGI:5430886

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Bves

blood vessel epicardial substance

acts_upstream_of_or_within

ISO

MGI:2385915 (MGI:5424322|PMID:22354168)

RGD

PMID:22354168

MGI:5424322

NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472

Cacna1e

calcium voltage-gated channel subunit alpha1 E

acts_upstream_of_or_within

ISO

MGI:3526823 (MGI:3614618|PMID:14976402)

RGD

PMID:14976402

MGI:3614618

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

Cacna1g

calcium voltage-gated channel subunit alpha1 G

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:2182962 (MGI:3714901|PMID:16690884)
GO_REF:0000107

RGD
Ensembl

PMID:16690884

GO_REF:0000107 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Calca

calcitonin-related polypeptide alpha

acts_upstream_of_or_within

ISO

MGI:2445489 (MGI:2445452|PMID:11717154)

RGD

PMID:11717154

MGI:2445452

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

Calm1

calmodulin 1

involved_in

ISO
IEA

(PMID:23040497)
GO_REF:0000107

RGD
Ensembl

PMID:23040497

GO_REF:0000107

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

Calm2

calmodulin 2

involved_in

ISO

(PMID:23040497)

RGD

PMID:23040497

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

Calm3

calmodulin 3

involved_in

ISO

(PMID:23040497)

RGD

PMID:23040497

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

Casq2

calsequestrin 2

involved_in

ISO
IEA

(PMID:15485681), (PMID:16601229), (PMID:16908766)
GO_REF:0000107
(MGI:3689635|PMID:16932808)

RGD
Ensembl

PMID:15485681 PMID:16601229 PMID:16908766 PMID:16932808

GO_REF:0000107 MGI:3689635

NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267

Cav3

caveolin 3

involved_in

ISO

(PMID:17060380)

RGD

PMID:17060380

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

Dmd

dystrophin

involved_in

ISO

(PMID:19027585)
(MGI:4420848|PMID:20080623)

RGD

PMID:19027585 PMID:20080623

MGI:4420848

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

Drd2

dopamine receptor D2

acts_upstream_of_or_within

ISO

MGI:1857875 (MGI:3608592|PMID:11566895)

RGD

PMID:11566895

MGI:3608592

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

Ednra

endothelin receptor type A

involved_in

ISO
IEA

MGI:102720 (MGI:3654957|PMID:16399858)
GO_REF:0000107

RGD
Ensembl

PMID:16399858

GO_REF:0000107 MGI:3654957

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

Ednrb

endothelin receptor type B

involved_in

ISO

MGI:105923 (MGI:3654957|PMID:16399858)

RGD

PMID:16399858

MGI:3654957

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

Epas1

endothelial PAS domain protein 1

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:1861921 (MGI:1313089|PMID:9808618)

Ensembl
RGD

PMID:9808618

GO_REF:0000107 MGI:1313089

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

Fkbp1b

FKBP prolyl isomerase 1B

acts_upstream_of_or_within

ISO

MGI:3623214 (MGI:3639647|PMID:16672364)

RGD

PMID:16672364

MGI:3639647

NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653

Gpd1l1

glycerol-3-phosphate dehydrogenase 1 like 1

involved_in

ISO

(PMID:17967977), (PMID:19666841)

RGD

PMID:17967977 PMID:19666841

NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

involved_in

ISO
ISS

(PMID:16407510)
GO_REF:0000024

RGD
UniProt

PMID:16407510

GO_REF:0000024

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Hrc

histidine rich calcium binding protein

involved_in

ISO

(PMID:18617481)

RGD

PMID:18617481

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

Irx5

iroquois homeobox 5

acts_upstream_of_or_within

ISO

MGI:3610374 (MGI:3690830|PMID:16239150)

RGD

PMID:16239150

MGI:3690830

NCBI chr19:14,639,052...14,643,911
Ensembl chr19:14,624,225...14,642,318

Kcnj8

potassium inwardly-rectifying channel, subfamily J, member 8

acts_upstream_of_or_within

ISO

MGI:6358100 (MGI:6193143|PMID:29666184)

RGD

PMID:29666184

MGI:6193143

NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

ISO

MGI:3056651 (MGI:4834732|PMID:20368164)

RGD

PMID:20368164

MGI:4834732

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

Mc3r

melanocortin 3 receptor

IMP

RGD

PMID:21091037

RGD:6484594

NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444

Mdm2

MDM2 proto-oncogene

acts_upstream_of_or_within

ISO

MGI:107934 (MGI:5440773|PMID:22821713)

RGD

PMID:22821713

MGI:5440773

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

Mdm4

MDM4 regulator of p53

acts_upstream_of_or_within

ISO

MGI:96952 (MGI:5440773|PMID:22821713)

RGD

PMID:22821713

MGI:5440773

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

Mybpc3

myosin binding protein C3

acts_upstream_of_or_within

ISO

(MGI:1352072|PMID:10532952)

RGD

PMID:10532952

MGI:1352072

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

Myh6

myosin heavy chain 6

involved_in
acts_upstream_of_or_within

ISO
IEA

(PMID:15621050)
MGI:2182704 (MGI:1202509|PMID:9541509)
GO_REF:0000107

RGD
Ensembl

PMID:9541509 PMID:15621050

GO_REF:0000107 MGI:1202509

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

Myh7

myosin heavy chain 7

involved_in

ISO
IEA

(PMID:15621050)
GO_REF:0000107

RGD
Ensembl

PMID:15621050

GO_REF:0000107

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

Oxt

oxytocin/neurophysin I prepropeptide

IDA

RGD

PMID:3668162

RGD:2304216

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

Pde4d

phosphodiesterase 4D

involved_in

ISO

(MGI:3690823|PMID:16213210)

RGD

PMID:16213210

MGI:3690823

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

Pmch

pro-melanin-concentrating hormone

IDA

RGD

PMID:17045349

RGD:1642492

NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250

Popdc2

popeye domain containing 2

acts_upstream_of_or_within

ISO

MGI:3773727 (MGI:5424322|PMID:22354168)

RGD

PMID:22354168

MGI:5424322

NCBI chr11:62,351,843...62,398,688
Ensembl chr11:62,374,759...62,390,756

Ryr2

ryanodine receptor 2

involved_in

ISO

(PMID:11159936), (PMID:12919952), (PMID:15197150)
(MGI:3820489|PMID:17872467)

RGD

PMID:11159936 PMID:12919952 PMID:15197150 PMID:17872467

MGI:3820489

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Scn10a

sodium voltage-gated channel alpha subunit 10

involved_in

ISO
IBA

(PMID:20062061), (PMID:21041692)
PMID:21873635

RGD

PMID:20062061 PMID:21041692 PMID:21873635

RGD:13792537

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISS
IBA
ISO

GO_REF:0000024
PMID:21873635
(PMID:10471492), (PMID:18065446), (PMID:18616619), (PMID:21895525), (PMID:22529811), (PMID:23085483), (PMID:26279430), (PMID:26392562)

BHF-UCL
RGD

PMID:10471492 PMID:18065446 PMID:18616619 PMID:21895525 PMID:22529811 More...

GO_REF:0000024, RGD:13792537

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Sema3a

semaphorin 3A

acts_upstream_of_or_within

ISO

MGI:2158944 (MGI:3711619|PMID:17417650)

RGD

PMID:17417650

MGI:3711619

NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432

Shox2

SHOX homeobox 2

acts_upstream_of
involved_in

ISO
IEA

(MGI:3836832|PMID:19166829)
GO_REF:0000107

RGD
Ensembl

PMID:19166829

GO_REF:0000107 MGI:3836832

NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143

Slc1a1

solute carrier family 1 member 1

involved_in

ISO

MGI:2655190 (MGI:5584094|PMID:23361868)

RGD

PMID:23361868

MGI:5584094

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

Slc8a1

solute carrier family 8 member A1

involved_in

ISO

(MGI:1927695|PMID:10967099)

RGD

PMID:10967099

MGI:1927695

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

Snta1

syntrophin, alpha 1

involved_in

ISO

(PMID:18591664)

RGD

PMID:18591664

NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709

Tmem161b

transmembrane protein 161B

involved_in

ISO

(MGI:6509747|PMID:33597309)

RGD

PMID:33597309

MGI:6509747

NCBI chr 2:14,714,451...14,793,809
Ensembl chr 2:14,715,701...14,793,803

Tnni3k

TNNI3 interacting kinase

involved_in

ISO
IEA
ISS

UniProtKB:Q5GIG6 (PMID:23236294), (PMID:24925317)
GO_REF:0000107
GO_REF:0000024
(MGI:5474909|PMID:23236294)

RGD
Ensembl
BHF-UCL

PMID:23236294 PMID:24925317

GO_REF:0000024 GO_REF:0000107 MGI:5474909

NCBI chr 2:243,737,346...244,005,319
Ensembl chr 2:243,710,950...244,005,268

Trpv4

transient receptor potential cation channel, subfamily V, member 4

NOT|involved_in

IMP

PMID:23136043

UniProt

PMID:23136043

RGD:10400856

NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517

regulation of heart rate by cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ace

angiotensin I converting enzyme

involved_in

IEA

GO_REF:0000107

Ensembl

GO_REF:0000107

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

Akap9

A-kinase anchoring protein 9

involved_in

ISO

(PMID:18093912)

RGD

PMID:18093912

NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606

Ank2

ankyrin 2

involved_in

ISO

(PMID:12571597), (PMID:15178757), (PMID:17242276), (PMID:21859974)
(MGI:2176661|PMID:11781319), (MGI:2449848|PMID:12571597), (MGI:3044878|PMID:15178757)

RGD

PMID:11781319 PMID:12571597 PMID:15178757 PMID:17242276 PMID:21859974

MGI:2176661 MGI:2449848 MGI:3044878

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Bin1

bridging integrator 1

involved_in

IEA
ISO

GO_REF:0000107
(MGI:5583915|PMID:24836577)

Ensembl
RGD

PMID:24836577

GO_REF:0000107 MGI:5583915

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

Cacna1c

calcium voltage-gated channel subunit alpha1 C

involved_in

ISO
ISS

(PMID:15454078), (PMID:15863612), (PMID:17224476), (PMID:26253506)
GO_REF:0000024

RGD
BHF-UCL

PMID:15454078 PMID:15863612 PMID:17224476 PMID:26253506

GO_REF:0000024

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Cacna1d

calcium voltage-gated channel subunit alpha1 D

involved_in
acts_upstream_of_or_within

ISO
IEA

(PMID:21131953)
GO_REF:0000107
MGI:2180141 (MGI:3583874|PMID:12700358)

RGD
Ensembl

PMID:12700358 PMID:21131953

GO_REF:0000107 MGI:3583874

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Cacna2d1

calcium voltage-gated channel auxiliary subunit alpha2delta 1

involved_in

ISO
IEA

(PMID:25527503)
GO_REF:0000107

RGD
Ensembl

PMID:25527503

GO_REF:0000107

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

Cacnb2

calcium voltage-gated channel auxiliary subunit beta 2

involved_in

ISO
IEA
ISS

(PMID:17224476)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
BHF-UCL

PMID:17224476

GO_REF:0000024 GO_REF:0000107

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

Cav1

caveolin 1

involved_in

ISO
IEA

(MGI:5607357|PMID:25017399)
GO_REF:0000107

RGD
Ensembl

PMID:25017399

GO_REF:0000107 MGI:5607357

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Ctnna3

catenin alpha 3

involved_in

ISO

(PMID:23136403)

RGD

PMID:23136403

NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978

Dsc2

desmocollin 2

involved_in

ISO

(PMID:23863954)

RGD

PMID:23863954

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

Dsg2

desmoglein 2

involved_in

ISO

(PMID:16505173), (PMID:23381804)

RGD

PMID:16505173 PMID:23381804

NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156

Dsp

desmoplakin

involved_in

ISO

(PMID:12373648)

RGD

PMID:12373648

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

Gja5

gap junction protein, alpha 5

acts_upstream_of_or_within

ISO

MGI:2445466 (MGI:3664488|PMID:11046183)

RGD

PMID:11046183

MGI:3664488

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

involved_in

ISO
IEA

(PMID:12750403)
GO_REF:0000107

RGD
Ensembl

PMID:12750403

GO_REF:0000107

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Isl1

ISL LIM homeobox 1

acts_upstream_of
involved_in

ISO
IEA

(MGI:5688210|PMID:26193633)
GO_REF:0000107

RGD
Ensembl

PMID:26193633

GO_REF:0000107 MGI:5688210

NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584

Jup

junction plakoglobin

involved_in

ISO
IEA

(PMID:17924338)
GO_REF:0000107

RGD
Ensembl

PMID:17924338

GO_REF:0000107

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

Kcna5

potassium voltage-gated channel subfamily A member 5

involved_in

ISO

(PMID:19343045), (PMID:23264583)

RGD

PMID:19343045 PMID:23264583

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

Kcnd3

potassium voltage-gated channel subfamily D member 3

involved_in
acts_upstream_of_or_within

ISO
IEA

(PMID:21349352)
(MGI:6402838|PMID:32109384)
GO_REF:0000107

RGD
Ensembl

PMID:21349352 PMID:32109384

GO_REF:0000107 MGI:6402838

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

Kcne1

potassium voltage-gated channel subfamily E regulatory subunit 1

involved_in
acts_upstream_of_or_within

ISO
IBA

(PMID:10400998)
MGI:1857442 (MGI:3615054|PMID:14561835)
PMID:21873635

RGD

PMID:10400998 PMID:14561835 PMID:21873635

MGI:3615054, RGD:13792537

NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901

Kcne2

potassium voltage-gated channel subfamily E regulatory subunit 2

involved_in

ISO
IBA

(PMID:10219239)
PMID:21873635

RGD

PMID:10219239 PMID:21873635

RGD:13792537

NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043

Kcne3

potassium voltage-gated channel subfamily E regulatory subunit 3

involved_in

ISO
IBA

(PMID:22987075)
PMID:21873635

RGD

PMID:22987075 PMID:21873635

RGD:13792537

NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020

Kcne4

potassium voltage-gated channel subfamily E regulatory subunit 4

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr 9:80,243,429...80,251,533
Ensembl chr 9:80,247,379...80,250,979

Kcne5

potassium voltage-gated channel subfamily E regulatory subunit 5

involved_in

IBA
ISO

PMID:21873635
(PMID:18313602), (PMID:21493962)

RGD

PMID:18313602 PMID:21493962 PMID:21873635

RGD:13792537

NCBI chr X:105,930,398...105,931,013
Ensembl chr X:105,930,398...105,931,013

Kcnh2

potassium voltage-gated channel subfamily H member 2

acts_upstream_of_or_within
involved_in

ISO
IBA

(MGI:1860395|PMID:10843886)
PMID:21873635
(PMID:7889573)
(PMID:21536673)

RGD

PMID:7889573 PMID:10843886 PMID:21536673 PMID:21873635

MGI:1860395, RGD:13792537

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

Kcnh6

potassium voltage-gated channel subfamily H member 6

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr10:90,949,240...90,970,746
Ensembl chr10:90,949,846...90,970,701

Kcnj2

potassium inwardly-rectifying channel, subfamily J, member 2

involved_in

ISO

(PMID:15761194)

RGD

PMID:15761194

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

Kcnj5

potassium inwardly-rectifying channel, subfamily J, member 5

involved_in

ISO
IEA

(PMID:20560207)
GO_REF:0000107

RGD
Ensembl

PMID:20560207

GO_REF:0000107

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

Kcnq1

potassium voltage-gated channel subfamily Q member 1

involved_in

ISO
IEA

(PMID:8528244)
GO_REF:0000107

RGD
Ensembl

PMID:8528244

GO_REF:0000107

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

Pkp2

plakophilin 2

involved_in

ISO

(PMID:17980246), (PMID:22889254)

RGD

PMID:17980246 PMID:22889254

NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730

Rbfox2

RNA binding fox-1 homolog 2

acts_upstream_of_or_within

ISO

MGI:6442563 (MGI:6402838|PMID:32109384)

RGD

PMID:32109384

MGI:6402838

NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691

Scn1b

sodium voltage-gated channel beta subunit 1

involved_in

IBA
IEA
ISO

PMID:21873635
GO_REF:0000107
(PMID:19808477)

Ensembl
RGD

PMID:19808477 PMID:21873635

GO_REF:0000107, RGD:13792537

NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739

Scn2b

sodium voltage-gated channel beta subunit 2

involved_in

ISO

(PMID:19808477)

RGD

PMID:19808477

NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765

Scn3b

sodium voltage-gated channel beta subunit 3

involved_in

ISO
IBA

(PMID:20042427), (PMID:21051419)
PMID:21873635

RGD

PMID:20042427 PMID:21051419 PMID:21873635

RGD:13792537

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

Scn4b

sodium voltage-gated channel beta subunit 4

involved_in

ISO

(PMID:17592081)

RGD

PMID:17592081

NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in
acts_upstream_of_or_within

ISS
IEA
ISO

BHF-UCL
Ensembl
RGD

PMID:11972032 PMID:15809371 PMID:15932895 PMID:16172272 PMID:21895525 More...

GO_REF:0000024 GO_REF:0000107 MGI:2179151 MGI:3629469 MGI:3695100 MGI:4354492 MGI:6402838

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Src

SRC proto-oncogene, non-receptor tyrosine kinase

involved_in

IEA

GO_REF:0000107

Ensembl

GO_REF:0000107

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

Trpm4

transient receptor potential cation channel, subfamily M, member 4

involved_in

ISO
IEA

(PMID:27207958)
GO_REF:0000107

RGD
Ensembl

PMID:27207958

GO_REF:0000107

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

regulation of heart rate by chemical signal

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ffar3

free fatty acid receptor 3

acts_upstream_of_or_within

ISO

MGI:5013799 (MGI:5009064|PMID:21518883)

RGD

PMID:21518883

MGI:5009064

NCBI chr 1:86,105,388...86,106,728
Ensembl chr 1:86,104,920...86,106,849

Nos1ap

nitric oxide synthase 1 adaptor protein

involved_in

ISO

(PMID:19247217)

RGD

PMID:19247217

NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949

Srebf1

sterol regulatory element binding transcription factor 1

acts_upstream_of_or_within

ISO

MGI:2177773 (MGI:3772404|PMID:18060044)

RGD

PMID:18060044

MGI:3772404

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

regulation of Purkinje myocyte action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gja5

gap junction protein, alpha 5

involved_in

ISO

(PMID:22247482)

RGD

PMID:22247482

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

regulation of SA node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(PMID:12571597), (PMID:18832177)
(MGI:2449848|PMID:12571597)

RGD

PMID:12571597 PMID:18832177

MGI:2449848

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Ryr2

ryanodine receptor 2

involved_in

ISO
IEA

(PMID:17875969)
GO_REF:0000107

RGD
Ensembl

PMID:17875969

GO_REF:0000107

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Tbx18

T-box transcription factor 18

acts_upstream_of

ISO

(PMID:23242162)

RGD

PMID:23242162

NCBI chr 8:88,652,054...88,680,081
Ensembl chr 8:88,652,054...88,680,058

regulation of the force of heart contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adrenomedullin

RGD

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

apelin

RGD

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

Atp1a1

ATPase Na+/K+ transporting subunit alpha 1

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:2451290|MGI:3527337 (MGI:1337471|PMID:10360172), (MGI:3525392|PMID:15485817)
GO_REF:0000107

RGD
Ensembl

PMID:10360172 PMID:15485817

GO_REF:0000107 MGI:1337471 MGI:3525392

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

Atp1a2

ATPase Na+/K+ transporting subunit alpha 2

acts_upstream_of_or_within

ISO

MGI:2451291 (MGI:1337471|PMID:10360172)

RGD

PMID:10360172

MGI:1337471

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

Atp2a2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:97622 (MGI:1347184|PMID:10555147)
GO_REF:0000107

RGD
Ensembl

PMID:10555147

GO_REF:0000107 MGI:1347184

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

Cav1

caveolin 1

acts_upstream_of_or_within

ISO

MGI:2154537 (MGI:3612726|PMID:16380094)

RGD

PMID:16380094

MGI:3612726

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

chromogranin A

RGD

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

Csrp3

cysteine and glycine rich protein 3

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:97622 (MGI:1347184|PMID:10555147)

Ensembl
RGD

PMID:10555147

GO_REF:0000107 MGI:1347184

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

Gaa

alpha glucosidase

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:2179961 (MGI:2136118|PMID:11328962)

Ensembl
RGD

PMID:11328962

GO_REF:0000107 MGI:2136118

NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836

Glrx3

glutaredoxin 3

involved_in

ISO

(MGI:4461873|PMID:18258855)

RGD

PMID:18258855

MGI:4461873

NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010

Grk2

G protein-coupled receptor kinase 2

acts_upstream_of_or_within
involved_in

ISO
IBA

MGI:87937 (MGI:84440|PMID:7761854)
PMID:21873635

RGD

PMID:7761854 PMID:21873635

MGI:84440, RGD:13792537

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

interferon gamma

RGD

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Myh6

myosin heavy chain 6

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:2182704 (MGI:1202509|PMID:9541509)
(PMID:15621050)

Ensembl
RGD

PMID:9541509 PMID:15621050

GO_REF:0000107 MGI:1202509

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

Myh7

myosin heavy chain 7

involved_in

ISO
IEA

(PMID:15621050)
GO_REF:0000107

RGD
Ensembl

PMID:15621050

GO_REF:0000107

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

Myl2

myosin light chain 2

involved_in

IDA

PMID:15331360

UniProt

PMID:15331360

RGD:10400860

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

Myl3

myosin light chain 3

involved_in

ISO
IEA

(PMID:16675844)
GO_REF:0000107

RGD
Ensembl

PMID:16675844

GO_REF:0000107

NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816

Myl4

myosin, light chain 4

involved_in

ISO

(PMID:16675844)

RGD

PMID:16675844

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

phosphodiesterase 5A

RGD

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

Pebp1

phosphatidylethanolamine binding protein 1

IDA

RGD

PMID:16608915

RGD:2302820

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

Pln

phospholamban

acts_upstream_of_or_within

ISO

MGI:1330824|MGI:2158357|MGI:88110 (MGI:1347184|PMID:10555147), (MGI:3655341|PMID:9118481)

RGD

PMID:9118481 PMID:10555147

MGI:1347184 MGI:3655341

NCBI chr20:32,629,537...32,639,559

Prkca

protein kinase C, alpha

acts_upstream_of_or_within

ISO

MGI:3037088 (MGI:3033566|PMID:14966518)

RGD

PMID:14966518

MGI:3033566

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

Slc8a1

solute carrier family 8 member A1

acts_upstream_of_or_within

ISO

MGI:3609617 (MGI:3607962|PMID:12767889)

RGD

PMID:12767889

MGI:3607962

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

Slc9a1

solute carrier family 9 member A1

IMP

RGD

PMID:21659487

RGD:6771329

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

regulation of the force of heart contraction by cardiac conduction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Pln

phospholamban

acts_upstream_of_or_within

ISO

MGI:2158357 (MGI:1352349|PMID:10644605)

RGD

PMID:10644605

MGI:1352349

NCBI chr20:32,629,537...32,639,559

Slc9a1

solute carrier family 9 member A1

involved_in

ISO

(PMID:21359875)

RGD

PMID:21359875

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

regulation of the force of heart contraction by chemical signal

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cav1

caveolin 1

acts_upstream_of_or_within
involved_in

ISO
IEA

MGI:97362 (MGI:3832129|PMID:18951881)
GO_REF:0000107

RGD
Ensembl

PMID:18951881

GO_REF:0000107 MGI:3832129

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Nos3

nitric oxide synthase 3

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:102709 (MGI:3832129|PMID:18951881)

Ensembl
RGD

PMID:18951881

GO_REF:0000107 MGI:3832129

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

regulation of vascular associated smooth muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adra2b

adrenoceptor alpha 2B

IMP

RGD

PMID:18054907

RGD:2313547

NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355

Atp2b1

ATPase plasma membrane Ca2+ transporting 1

involved_in

ISS
IEA
ISO

GO_REF:0000024
GO_REF:0000107
(MGI:6282934|PMID:24805951)

UniProt
Ensembl
RGD

PMID:24805951

GO_REF:0000024 GO_REF:0000107 MGI:6282934

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

Chrm3

cholinergic receptor, muscarinic 3

involved_in

IBA

PMID:21873635

GO_Central

PMID:21873635

RGD:13792537

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

Map2k1

mitogen activated protein kinase kinase 1

IMP

inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001)

RGD

PMID:10198244

RGD:2293329

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

P2rx1

purinergic receptor P2X 1

acts_upstream_of_or_within

ISO

MGI:2181608 (MGI:3694186|PMID:16920810)

RGD

PMID:16920810

MGI:3694186

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

Zdhhc21

zinc finger DHHC-type palmitoyltransferase 21

involved_in

ISO

(MGI:5921050|PMID:26715683)

RGD

PMID:26715683

MGI:5921050

NCBI chr 5:97,227,621...97,286,866
Ensembl chr 5:97,229,345...97,286,537

regulation of vasoconstriction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adra1a

adrenoceptor alpha 1A

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

Adra1b

adrenoceptor alpha 1B

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

Adra2a

adrenoceptor alpha 2A

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

Agtr1a

angiotensin II receptor, type 1a

involved_in

ISO

(PMID:15117835)

RGD

PMID:15117835

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

Agtr1b

angiotensin II receptor, type 1b

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232

Asic2

acid sensing ion channel subunit 2

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107
MGI:2180111 (MGI:3794223|PMID:18296560)

Ensembl
RGD

PMID:18296560

GO_REF:0000107 MGI:3794223

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

Atp1a2

ATPase Na+/K+ transporting subunit alpha 2

acts_upstream_of_or_within

ISO

MGI:2451291|MGI:98496 (MGI:3525892|PMID:14627611)

RGD

PMID:14627611

MGI:3525892

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

Cacna1c

calcium voltage-gated channel subunit alpha1 C

acts_upstream_of_or_within

ISO

MGI:2389040|MGI:2674119 (MGI:3663939|PMID:14609949)

RGD

PMID:14609949

MGI:3663939

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

dopamine receptor D1

RGD

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

Edn1

endothelin 1

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

Edn2

endothelin 2

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

Edn3

endothelin 3

involved_in

TAS
IEA

GO_REF:0000002

InterPro
RGD

PMID:12184995

GO_REF:0000002, RGD:1299957

NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093

Htr1a

5-hydroxytryptamine receptor 1A

involved_in

IEA

GO_REF:0000002

InterPro

GO_REF:0000002

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

Kcna5

potassium voltage-gated channel subfamily A member 5

acts_upstream_of_or_within

ISO

MGI:2384510 (MGI:2138011|PMID:11481235)

RGD

PMID:11481235

MGI:2138011

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

P2rx1

purinergic receptor P2X 1

acts_upstream_of_or_within

ISO

MGI:2181608 (MGI:3699669|PMID:14679185)

RGD

PMID:14679185

MGI:3699669

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

Per2

period circadian regulator 2

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3794791|PMID:17404161)

UniProt
RGD

PMID:17404161

GO_REF:0000024 MGI:3794791

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

Prkcq

protein kinase C, theta

IEP

RGD

PMID:16951045

RGD:1625607

NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704

Tbxa2r

thromboxane A2 receptor

acts_upstream_of_or_within

ISO

MGI:88106 (MGI:3525892|PMID:14627611)

RGD

PMID:14627611

MGI:3525892

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

regulation of vasoconstriction by circulating norepinephrine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Snta1

syntrophin, alpha 1

acts_upstream_of_or_within

ISO

MGI:2179769 (MGI:3691879|PMID:12600881)

RGD

PMID:12600881

MGI:3691879

NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709

regulation of vein smooth muscle contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adrb2

adrenoceptor beta 2

enables

IDA

salbutamol, isoproterenol, clenbuterol, norepinephrine

RGD

PMID:6289140

RGD:2301944

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

Htr7

5-hydroxytryptamine receptor 7

IMP

RGD

PMID:31125290

RGD:14696717

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

regulation of ventricular cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1c

calcium voltage-gated channel subunit alpha1 C

involved_in

ISS
ISO

GO_REF:0000024
(PMID:15454078), (PMID:26253506)

BHF-UCL
RGD

PMID:15454078 PMID:26253506

GO_REF:0000024

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

Cav1

caveolin 1

involved_in

ISO
IEA

(MGI:5607357|PMID:25017399)
GO_REF:0000107

RGD
Ensembl

PMID:25017399

GO_REF:0000107 MGI:5607357

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Ctnna3

catenin alpha 3

involved_in

ISO

(PMID:23136403)

RGD

PMID:23136403

NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978

Dlg1

discs large MAGUK scaffold protein 1

involved_in

IEA
ISO

GO_REF:0000107
(MGI:5816439|PMID:25447080)

Ensembl
RGD

PMID:25447080

GO_REF:0000107 MGI:5816439

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

Dsc2

desmocollin 2

involved_in

ISO

(PMID:23863954)

RGD

PMID:23863954

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

Dsg2

desmoglein 2

involved_in

ISO

(PMID:16505173), (PMID:23381804)

RGD

PMID:16505173 PMID:23381804

NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156

Dsp

desmoplakin

involved_in

ISO

(PMID:12373648)

RGD

PMID:12373648

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

Jup

junction plakoglobin

involved_in

ISO
IEA

(PMID:17924338)
GO_REF:0000107

RGD
Ensembl

PMID:17924338

GO_REF:0000107

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

Pkp2

plakophilin 2

involved_in

ISO

(PMID:22889254)

RGD

PMID:22889254

NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730

Ryr2

ryanodine receptor 2

involved_in

ISO
IEA

(PMID:17875969)
GO_REF:0000107

RGD
Ensembl

PMID:17875969

GO_REF:0000107

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

Trpm4

transient receptor potential cation channel, subfamily M, member 4

involved_in

ISO
IEA

(PMID:27207958)
GO_REF:0000107

RGD
Ensembl

PMID:27207958

GO_REF:0000107

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

SA node cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(MGI:5430886|PMID:18832177)

RGD

PMID:18832177

MGI:5430886

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Gja5

gap junction protein, alpha 5

acts_upstream_of_or_within

ISO

MGI:2445466 (MGI:3664488|PMID:11046183)

RGD

PMID:11046183

MGI:3664488

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

involved_in

ISO

(PMID:12750403)

RGD

PMID:12750403

NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639

Scn3b

sodium voltage-gated channel beta subunit 3

involved_in

ISO

(MGI:5294533|PMID:19796257)

RGD

PMID:19796257

MGI:5294533

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

Scn5a

sodium voltage-gated channel alpha subunit 5

involved_in

ISO
ISS

(PMID:18616619)
GO_REF:0000024

RGD
BHF-UCL

PMID:18616619

GO_REF:0000024

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

SA node cell to atrial cardiac muscle cell communication

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ank2

ankyrin 2

involved_in

ISO

(PMID:12571597), (PMID:18832177), (PMID:21859974)
(MGI:5430886|PMID:18832177)

RGD

PMID:12571597 PMID:18832177 PMID:21859974

MGI:5430886

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

SA node cell to atrial cardiac muscle cell signaling

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cacna1g

calcium voltage-gated channel subunit alpha1 G

involved_in

ISS
ISO

GO_REF:0000024
(MGI:3714901|PMID:16690884)

BHF-UCL
RGD

PMID:16690884

GO_REF:0000024 MGI:3714901

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

Term paths to the root

Path 1
Term	Annotations
biological_process	19574
multicellular organismal process	9171
regulation of multicellular organismal process	3351
regulation of system process	655
regulation of blood circulation	290
negative regulation of blood circulation +	28
positive regulation of blood circulation +	48
regulation of cerebral blood circulation +	1
regulation of gastric mucosal blood circulation +	3
regulation of heart contraction +	212
regulation of vasoconstriction +	98
Path 2
Term	Annotations
biological_process	19574
multicellular organismal process	9171
system process	3469
circulatory system process	608
blood circulation	579
regulation of blood circulation	290
negative regulation of blood circulation +	28
positive regulation of blood circulation +	48
regulation of cerebral blood circulation +	1
regulation of gastric mucosal blood circulation +	3
regulation of heart contraction +	212
regulation of vasoconstriction +	98

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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ONTOLOGY REPORT - ANNOTATIONS