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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of reactive oxygen species biosynthetic process
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Accession:GO:1903426 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.
Synonyms:exact_synonym: regulation of reactive oxygen species anabolism;   regulation of reactive oxygen species biosynthesis;   regulation of reactive oxygen species formation;   regulation of reactive oxygen species synthesis
 related_synonym: regulation of ROS formation;   regulation of ROS generation;   regulation of reactive oxygen species generation



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regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26210919)
Ensembl
UniProt
RGD
PMID:26210919 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Arg2 arginase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5810834|PMID:27214549)
Ensembl
RGD
PMID:27214549 GO_REF:0000107 MGI:5810834 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Ccn6 cellular communication network factor 6 involved_in ISO (PMID:27252383) RGD PMID:27252383 NCBI chr20:42,569,309...42,585,126
Ensembl chr20:42,569,309...42,585,126
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IMP RGD PMID:27279484 RGD:151347625 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO
IBA
(PMID:28779020)
PMID:21873635
(MGI:6103777|PMID:28779020)
RGD PMID:28779020 PMID:21873635 MGI:6103777, RGD:13792537 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868
JBrowse link
G Slc25a33 solute carrier family 25 member 33 involved_in ISO (PMID:20453889) RGD PMID:20453889 NCBI chr 5:160,195,040...160,219,961
Ensembl chr 5:160,195,042...160,219,961
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:5641585|PMID:25637806) RGD PMID:25637806 MGI:5641585 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Ucp1 uncoupling protein 1 involved_in NAS
ISO
PMID:20416274
(MGI:4837058|PMID:20416274)
RGD PMID:20416274 PMID:20416274 MGI:4837058, RGD:11541111 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649
JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in IMP PMID:31511561 UniProt PMID:31511561 RGD:126781736 NCBI chr  X:69,295,598...69,436,775
Ensembl chr  X:69,295,552...69,436,858
JBrowse link
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3836690|PMID:18723473), (MGI:5464985|PMID:22521832), (MGI:5790173|PMID:25583114)
UniProt
RGD
PMID:18723473 PMID:22521832 PMID:25583114 GO_REF:0000024 MGI:3836690 MGI:5464985 MGI:5790173 NCBI chr  X:151,428,334...151,450,115
Ensembl chr  X:151,428,578...151,450,115
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3836690|PMID:18723473)
UniProt
RGD
PMID:18723473 GO_REF:0000024 MGI:3836690 NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 IMP RGD PMID:22209705 RGD:13800744 NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator IMP RGD PMID:18292530 RGD:11341712 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 involved_in ISO
ISS
(PMID:25175347)
GO_REF:0000024
RGD
UniProt
PMID:25175347 GO_REF:0000024 NCBI chr 6:130,772,218...130,797,081
Ensembl chr 6:130,771,199...130,797,081
JBrowse link
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 IMP RGD PMID:23041468 RGD:10401126 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Hbp1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) RGD PMID:24675724 MGI:5754467 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IMP RGD PMID:22547655 RGD:10402548 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Ins2 insulin 2 involved_in ISO ComplexPortal:CPX-1134 (PMID:19188609) RGD PMID:19188609 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:28483668 RGD:12910717 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir181a2 microRNA 181a-2 involved_in ISO (PMID:23516523) RGD PMID:23516523 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO
GO_REF:0000024
(MGI:5908331|PMID:22611253)
UniProt
RGD
PMID:22611253 GO_REF:0000024 MGI:5908331 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha acts_upstream_of ISO (PMID:31574452) RGD PMID:31574452 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:24096089 RGD:10413842 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Rhoa ras homolog family member A involved_in ISO (MGI:5640904|PMID:25398325) RGD PMID:25398325 MGI:5640904 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:23422569 RGD:9585767 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc30a10 solute carrier family 30, member 10 involved_in ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268 PMID:22814254 NCBI chr 3:109,245,476...109,248,844
Ensembl chr 3:109,245,476...109,248,968
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Nox4 NADPH oxidase 4 IMP RGD PMID:27279484 RGD:151347625 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,470...12,623,615
Ensembl chr10:12,615,190...12,623,615
JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 involved_in ISO (PMID:26838550) RGD PMID:26838550 NCBI chr 7:106,404,844...106,476,902
Ensembl chr 7:106,404,958...106,476,902
JBrowse link
G Cd36 CD36 molecule involved_in ISO (MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:4438693 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Clcn3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2447864 (MGI:3663198|PMID:16522634)
Ensembl
RGD
PMID:16522634 GO_REF:0000107 MGI:3663198 NCBI chr16:29,127,419...29,200,133
Ensembl chr16:29,127,419...29,200,119
JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in ISO (PMID:22423966) RGD PMID:22423966 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Foxo3 forkhead box O3 IMP RGD PMID:24278276 RGD:10402204 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in IGI PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Hdac4 histone deacetylase 4 IMP RGD PMID:24166750 RGD:9681442 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Il4 interleukin 4 IDA RGD PMID:24073824 RGD:10402792 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lcn2 lipocalin 2 IDA RGD PMID:25557118 RGD:126790477 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir24-2 microRNA 24-2 involved_in ISO (PMID:21788589) RGD PMID:21788589 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790
JBrowse link
G Mir675 microRNA 675 acts_upstream_of ISO (PMID:31574452) RGD PMID:31574452 NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in ISO
IEA
(MGI:6201889|PMID:25049354)
GO_REF:0000107
RGD
Ensembl
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase IMP RGD PMID:21712532 RGD:9590189 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (MGI:5543357|PMID:22555455) RGD PMID:22555455 MGI:5543357 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of
involved_in
ISO
IEA
(MGI:5300086|PMID:22041900)
GO_REF:0000107
RGD
Ensembl
PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:24404184) RGD PMID:24404184 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G RGD1565355 similar to fatty acid translocase/CD36 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Slc5a3 solute carrier family 5 member 3 acts_upstream_of_or_within ISO (MGI:6414721|PMID:28128227) RGD PMID:28128227 MGI:6414721 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Tlr4 toll-like receptor 4 involved_in ISO
IEA
(MGI:4438693|PMID:20037584)
GO_REF:0000107
RGD
Ensembl
PMID:20037584 GO_REF:0000107 MGI:4438693 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:4438693 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    metabolic process 11461
      biosynthetic process 5814
        reactive oxygen species biosynthetic process 69
          regulation of reactive oxygen species biosynthetic process 58
            negative regulation of reactive oxygen species biosynthetic process + 25
            positive regulation of reactive oxygen species biosynthetic process + 27
            regulation of hydrogen peroxide biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 18737
    biological regulation 13318
      regulation of biological process 12598
        regulation of cellular process 11911
          regulation of cellular metabolic process 5498
            regulation of reactive oxygen species metabolic process 174
              regulation of reactive oxygen species biosynthetic process 58
                negative regulation of reactive oxygen species biosynthetic process + 25
                positive regulation of reactive oxygen species biosynthetic process + 27
                regulation of hydrogen peroxide biosynthetic process + 13
paths to the root