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ONTOLOGY REPORT - ANNOTATIONS

Term:reactive oxygen species biosynthetic process
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Accession:GO:1903409 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms:exact_synonym: reactive oxygen species anabolism;   reactive oxygen species biosynthesis;   reactive oxygen species formation;   reactive oxygen species synthesis
 related_synonym: ROS formation;   ROS generation;   reactive oxygen species generation


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reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor ISO RGD PMID:35788946 RGD:401793705 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
G GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 involved_in ISO (PMID:22573891) UniProt PMID:22573891 NCBI chr14:113,245,486...113,379,472
Ensembl chr14:113,245,502...113,379,471 		JBrowse link
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:23,392,202...23,414,318
Ensembl chr10:23,392,099...23,412,712 		JBrowse link
G LIPA lipase A, lysosomal acid type acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5560864|PMID:24287405) MGI
Ensembl		 PMID:24287405 GO_REF:0000107 MGI:5560864 NCBI chr14:101,131,372...101,254,739
Ensembl chr14:101,126,257...101,193,614 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO RGD PMID:21275845 RGD:41404729 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,266...11,839,354 		JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546 		JBrowse link
G CYBA cytochrome b-245 alpha chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3037497|PMID:14980704) MGI
Ensembl		 PMID:14980704 GO_REF:0000107 MGI:3037497 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3037497|PMID:14980704) MGI
Ensembl		 PMID:14980704 GO_REF:0000107 MGI:3037497 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100 		JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,572,533...126,603,084
Ensembl chr 1:126,572,492...126,603,082 		JBrowse link
G DUOX2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406 		JBrowse link
G GP91-PHOX NADPH oxidase heavy chain subunit acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr  X:33,654,656...33,678,346
Ensembl chr  X:33,643,648...33,680,580 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,266...11,839,354 		JBrowse link
G SOD1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within		 ISO
IEA
ISS		 (MGI:2682495|PMID:14679182) RGD
Ensembl
UniProt
MGI		 PMID:10640619 PMID:12514262 PMID:14679182 PMID:15880490 GO_REF:0000024 GO_REF:0000107 MGI:2682495 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
hypochlorous acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPO myeloperoxidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1333719|PMID:10085024) MGI
Ensembl		 PMID:10085024 GO_REF:0000107 MGI:1333719 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr12:49,730,741...49,754,362
Ensembl chr12:49,730,955...49,753,043 		JBrowse link
G CYCS cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581 		JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:7,423,083...7,441,583
Ensembl chr 3:7,427,395...7,441,567 		JBrowse link
G PRL prolactin involved_in IMP (PMID:24530842) AgBase PMID:24530842 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in ISO PMID:31511561 UniProt PMID:31511561 RGD:126781736 NCBI chr  X:60,186,559...60,313,098
Ensembl chr  X:60,186,814...60,313,064 		JBrowse link
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:124,485,076...124,501,742
Ensembl chr  X:124,485,076...124,501,741 		JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:71,123,187...71,180,758
Ensembl chr 5:71,122,325...71,180,723 		JBrowse link
G ADCY10 adenylate cyclase 10 ISO RGD PMID:32664470 RGD:329347825 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454 		JBrowse link
G APOPT1 apoptogenic 1, mitochondrial involved_in ISO (PMID:25175347) UniProt PMID:25175347
G ATP5MC1 ATP synthase membrane subunit c locus 1 ISO RGD PMID:22209705 RGD:13800744 NCBI chr12:25,110,540...25,113,481
Ensembl chr12:25,110,528...25,113,478 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO RGD PMID:18292530 RGD:11341712 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,616...104,835,630 		JBrowse link
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr12:49,730,741...49,754,362
Ensembl chr12:49,730,955...49,753,043 		JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:23041468 RGD:10401126 NCBI chr 1:92,421,235...92,425,053
Ensembl chr 1:92,421,230...92,425,044 		JBrowse link
G HBP1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) BHF-UCL PMID:24675724 MGI:5754467 NCBI chr 9:106,966,060...106,993,915
Ensembl chr 9:106,966,060...106,993,911 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO RGD PMID:26071548 RGD:401793712 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:22547655 RGD:10402548 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526 		JBrowse link
G INS insulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G LOC100513450 P antigen family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:43,489,559...43,496,654
Ensembl chr  X:43,446,109...43,494,094 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:28483668 RGD:12910717 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G MIR140 microRNA mir-140 ISO RGD PMID:32519270 RGD:329347827 NCBI chr 6:17,077,530...17,077,599
Ensembl chr 6:17,077,507...17,077,620 		JBrowse link
G MIR181A-1 microRNA mir-181a-1 involved_in ISO (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr10:21,696,653...21,696,756
Ensembl chr10:21,696,653...21,696,756 		JBrowse link
G MIR181A-2 microRNA mir-181a-2 involved_in ISO (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 1:265,497,249...265,497,328
Ensembl chr 1:265,497,249...265,497,328 		JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 ISO RGD PMID:26888427 RGD:11040458 NCBI chr 9:12,486,488...12,492,507
Ensembl chr 9:12,485,167...12,492,591 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha acts_upstream_of
involved_in		 ISO
IEA		 (PMID:31574452) ARUK-UCL
Ensembl		 PMID:31574452 GO_REF:0000107 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24096089 RGD:10413842 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872 		JBrowse link
G RHOA ras homolog family member A involved_in ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:23422569 RGD:9585767 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,605,142...126,615,736
Ensembl chr 1:126,605,142...126,615,719 		JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,616,631...126,620,359
Ensembl chr 1:126,613,201...126,623,388 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G NOX4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,212...22,776,534 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:39,091,439...39,105,633
Ensembl chr 3:39,091,443...39,106,615 		JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:28386847 RGD:329337357 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454 		JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:1,582,321...1,658,639
Ensembl chr 4:1,582,330...1,647,573 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15450084 RGD:2313867 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G CD36 CD36 molecule involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3663198|PMID:16522634) MGI
Ensembl		 PMID:16522634 GO_REF:0000107 MGI:3663198 NCBI chr14:20,037,628...20,127,160
Ensembl chr14:20,026,685...20,127,155 		JBrowse link
G CYBA cytochrome b-245 alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420 		JBrowse link
G FOXO3 forkhead box O3 ISO RGD PMID:24278276 RGD:10402204 NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,218...74,760,325 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994
G HDAC4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G IL4 interleukin 4 ISO RGD PMID:24073824 RGD:10402792 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:21712532 RGD:9590189 NCBI chr  X:57,521,091...57,558,467
Ensembl chr  X:57,521,098...57,558,515 		JBrowse link
G PARK7 Parkinsonism associated deglycase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5543357|PMID:22555455) MGI
Ensembl		 PMID:22555455 GO_REF:0000107 MGI:5543357 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:5300086|PMID:22041900) ARUK-UCL
Ensembl		 PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060 		JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:116,532,816...116,606,477
Ensembl chr 1:116,532,974...116,606,474 		JBrowse link
G SLC5A3 solute carrier family 5 member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6414721|PMID:28128227) ARUK-UCL
Ensembl		 PMID:28128227 GO_REF:0000107 MGI:6414721 NCBI chr13:197,688,632...197,723,323
Ensembl chr13:197,711,679...197,718,695 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094 		JBrowse link
G ARG2 arginase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:91,343,987...91,385,911
Ensembl chr 7:91,343,988...91,385,909 		JBrowse link
G CCN6 cellular communication network factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:78,005,442...78,020,595
Ensembl chr 1:78,005,847...78,019,709 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 ISO RGD PMID:27279484 RGD:151347625 NCBI chr 9:124,776,516...124,813,358
Ensembl chr 9:124,776,534...124,812,923 		JBrowse link
G PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr15:111,372,148...111,468,720
Ensembl chr15:111,372,173...111,467,899 		JBrowse link
G SLC25A33 solute carrier family 25 member 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:69,934,810...69,969,091
Ensembl chr 6:69,934,834...69,969,084 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:53,982,911...53,986,779
Ensembl chr 6:53,979,012...53,986,768 		JBrowse link
G UCP1 uncoupling protein 1 involved_in ISO (MGI:4837058|PMID:20416274) UniProt PMID:20416274 MGI:4837058 NCBI chr 8:86,522,028...86,526,162 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17396
    metabolic process 10259
      biosynthetic process 7053
        reactive oxygen species biosynthetic process 71
          hydrogen peroxide biosynthetic process + 21
          hypochlorous acid biosynthetic process 1
          negative regulation of reactive oxygen species biosynthetic process + 29
          positive regulation of reactive oxygen species biosynthetic process + 24
          regulation of reactive oxygen species biosynthetic process + 58
Path 2
Term Annotations click to browse term
  biological_process 17396
    metabolic process 10259
      cellular metabolic process 8988
        reactive oxygen species metabolic process 250
          reactive oxygen species biosynthetic process 71
            hydrogen peroxide biosynthetic process + 21
            hypochlorous acid biosynthetic process 1
            negative regulation of reactive oxygen species biosynthetic process + 29
            positive regulation of reactive oxygen species biosynthetic process + 24
            regulation of reactive oxygen species biosynthetic process + 58
paths to the root