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ONTOLOGY REPORT - ANNOTATIONS


Term:reactive oxygen species biosynthetic process
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Accession:GO:1903409 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms:exact_synonym: reactive oxygen species anabolism;   reactive oxygen species biosynthesis;   reactive oxygen species formation;   reactive oxygen species synthesis
 related_synonym: ROS formation;   ROS generation;   reactive oxygen species generation



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reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbf1 golgi-specific brefeldin A-resistance factor 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr19:46,140,948...46,274,949
Ensembl chr19:46,140,948...46,274,949
JBrowse link
G Inava innate immunity activator involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:136,141,260...136,162,045
Ensembl chr 1:136,141,269...136,162,002
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in ISO RGD
MGI
PMID:21275845 GO_REF:0000096 MGI:4417868 RGD:41404729 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:116,062,709...116,089,871
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cybb cytochrome b-245, beta polypeptide acts_upstream_of_or_within IMP (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 acts_upstream_of_or_within IMP (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 acts_upstream_of_or_within IMP (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Duox1 dual oxidase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,143,525...122,178,454
Ensembl chr 2:122,146,153...122,178,453
JBrowse link
G Duox2 dual oxidase 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,109,727...122,129,221
Ensembl chr 2:122,109,728...122,128,930
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within IMP (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Sod1 superoxide dismutase 1, soluble involved_in
acts_upstream_of_or_within
ISO
IMP
(MGI:2682495|PMID:14679182) MGI
RGD
PMID:10640619 PMID:12514262 PMID:14679182 PMID:15880490 GO_REF:0000096 MGI:2682495 MGI:4417868 MGI:4834177 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial involved_in ISO RGD
MGI
PMID:15642720 GO_REF:0000096 MGI:4417868 RGD:2291946 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
hypochlorous acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase acts_upstream_of_or_within IMP (MGI:1333719|PMID:10085024) MGI PMID:10085024 MGI:1333719 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosis, nephropathic involved_in ISO RGD
MGI
PMID:26482480 GO_REF:0000096 MGI:4417868 RGD:12910938 NCBI chr11:73,073,959...73,089,869
Ensembl chr11:73,074,422...73,089,868
JBrowse link
G Cycs cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Fyn Fyn proto-oncogene involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
JBrowse link
G Mpv17l Mpv17 transgene, kidney disease mutant-like involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr16:13,721,025...13,767,483
Ensembl chr16:13,721,025...13,767,483
JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO RGD
MGI
PMID:23590160 GO_REF:0000096 MGI:4417868 RGD:8694322 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr  X:103,324,171...103,457,452
Ensembl chr  X:103,324,263...103,457,462
JBrowse link
G Abcd1 ATP-binding cassette, sub-family D (ALD), member 1 involved_in IMP (MGI:3836690|PMID:18723473), (MGI:5464985|PMID:22521832), (MGI:5790173|PMID:25583114) UniProt PMID:18723473 PMID:22521832 PMID:25583114 MGI:3836690 MGI:5464985 MGI:5790173 NCBI chr  X:72,760,203...72,782,140
Ensembl chr  X:72,760,203...72,782,140
JBrowse link
G Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 involved_in IMP (MGI:3836690|PMID:18723473) UniProt PMID:18723473 MGI:3836690 NCBI chr15:91,029,878...91,076,706
Ensembl chr15:91,030,074...91,076,002
JBrowse link
G Atp5g1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) ISO RGD PMID:22209705 RGD:13800744 NCBI chr11:95,963,619...95,966,520
Ensembl chr11:95,959,678...95,966,496
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in ISO RGD
MGI
PMID:18292530 GO_REF:0000096 MGI:4417868 RGD:11341712 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:111,679,394...111,721,491
Ensembl chr12:111,679,695...111,721,487
JBrowse link
G Ctns cystinosis, nephropathic involved_in ISO RGD
MGI
PMID:26482480 GO_REF:0000096 MGI:4417868 RGD:12910938 NCBI chr11:73,073,959...73,089,869
Ensembl chr11:73,074,422...73,089,868
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:23041468 RGD:10401126 NCBI chr 9:78,385,735...78,389,006
Ensembl chr 9:78,385,731...78,396,433
JBrowse link
G Hbp1 high mobility group box transcription factor 1 involved_in IDA (MGI:5754467|PMID:24675724) BHF-UCL PMID:24675724 MGI:5754467 NCBI chr12:31,976,449...32,000,529
Ensembl chr12:31,976,253...32,000,534
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) involved_in ISO RGD
MGI
PMID:22547655 GO_REF:0000096 MGI:4417868 RGD:10402548 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Ins1 insulin I involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ins2 insulin II involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Mfn2 mitofusin 2 involved_in ISO RGD
MGI
PMID:28483668 GO_REF:0000096 MGI:4417868 RGD:12910717 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
JBrowse link
G Mir181a-1 microRNA 181a-1 involved_in ISO (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 1:137,894,193...137,894,279
Ensembl chr 1:137,894,193...137,894,279
JBrowse link
G Mir181a-2 microRNA 181a-2 involved_in ISO (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 2:38,742,747...38,742,822
Ensembl chr 2:38,742,747...38,742,822
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 involved_in ISO RGD
MGI
PMID:26888427 GO_REF:0000096 MGI:4417868 RGD:11040458 NCBI chr 7:97,049,210...97,057,007
Ensembl chr 7:97,049,210...97,057,009
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 involved_in IMP (MGI:5908331|PMID:22611253) UniProt PMID:22611253 MGI:5908331 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha acts_upstream_of ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO RGD
MGI
PMID:24096089 GO_REF:0000096 MGI:4417868 RGD:10413842 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
JBrowse link
G Rhoa ras homolog family member A involved_in IMP (MGI:5640904|PMID:25398325) CACAO PMID:25398325 MGI:5640904 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO RGD
MGI
PMID:23422569 GO_REF:0000096 MGI:4417868 RGD:9585767 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc30a10 solute carrier family 30, member 10 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:185,187,045...185,200,959
Ensembl chr 1:185,187,045...185,200,959
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,134,012...122,144,255
Ensembl chr 2:122,132,672...122,144,211
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,129,381...122,133,366
Ensembl chr 2:122,129,381...122,133,366
JBrowse link
G Mfn2 mitofusin 2 involved_in ISO RGD
MGI
PMID:27997345 GO_REF:0000096 MGI:4417868 RGD:12910740 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial involved_in ISO RGD
MGI
PMID:19306371 GO_REF:0000096 MGI:4417868 RGD:13506652 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISO RGD
MGI
PMID:27279484 GO_REF:0000096 MGI:4417868 RGD:151347625 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial involved_in ISO RGD
MGI
PMID:20529999 GO_REF:0000096 MGI:4417868 RGD:27095884 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:23,788,820...23,818,729
Ensembl chr17:23,794,818...23,818,461
JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr15:74,388,045...74,461,314
Ensembl chr15:74,388,044...74,461,314
JBrowse link
G Cd36 CD36 molecule involved_in IMP (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Clcn3 chloride channel, voltage-sensitive 3 acts_upstream_of_or_within IMP (MGI:3663198|PMID:16522634) MGI PMID:16522634 MGI:3663198 NCBI chr 8:61,363,423...61,436,353
Ensembl chr 8:61,363,423...61,436,334
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Foxo3 forkhead box O3 involved_in ISO RGD
MGI
PMID:24278276 GO_REF:0000096 MGI:4417868 RGD:10402204 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G H19 H19, imprinted maternally expressed transcript acts_upstream_of ISO (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,266...142,131,880
JBrowse link
G Hdac4 histone deacetylase 4 involved_in ISO RGD
MGI
PMID:24166750 GO_REF:0000096 MGI:4417868 RGD:9681442 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
JBrowse link
G Il4 interleukin 4 involved_in ISO RGD
MGI
PMID:24073824 GO_REF:0000096 MGI:4417868 RGD:10402792 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Lcn2 lipocalin 2 involved_in ISO RGD
MGI
PMID:25557118 GO_REF:0000096 MGI:4417868 RGD:126790477 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Mfn2 mitofusin 2 involved_in ISO RGD
MGI
PMID:27997345 GO_REF:0000096 MGI:4417868 RGD:12910740 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
JBrowse link
G Mir24-1 microRNA 24-1 involved_in ISO (PMID:21788589) BHF-UCL PMID:21788589 NCBI chr13:63,449,022...63,449,089
Ensembl chr13:63,449,022...63,449,089
JBrowse link
G Mir24-2 microRNA 24-2 involved_in ISO (PMID:21788589) BHF-UCL PMID:21788589 NCBI chr 8:84,935,444...84,935,550
Ensembl chr 8:84,935,444...84,935,550
JBrowse link
G Mir675 microRNA 675 acts_upstream_of ISO (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr 7:142,130,801...142,130,884
Ensembl chr 7:142,130,801...142,130,884
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IMP (MGI:6201889|PMID:25049354) ARUK-UCL PMID:25049354 MGI:6201889 NCBI chr 9:7,558,430...7,568,487
Ensembl chr 9:7,558,457...7,568,486
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) involved_in ISO RGD
MGI
PMID:21712532 GO_REF:0000096 MGI:4417868 RGD:9590189 NCBI chr  X:100,683,617...100,727,957
Ensembl chr  X:100,683,666...100,727,957
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 acts_upstream_of_or_within IDA (MGI:5543357|PMID:22555455) MGI PMID:22555455 MGI:5543357 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of IMP (MGI:5300086|PMID:22041900) ARUK-UCL PMID:22041900 MGI:5300086 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911
JBrowse link
G Slc5a3 solute carrier family 5 (inositol transporters), member 3 acts_upstream_of_or_within IMP (MGI:6414721|PMID:28128227) ARUK-UCL PMID:28128227 MGI:6414721 NCBI chr16:91,855,210...91,884,361
Ensembl chr16:91,855,210...91,884,361
JBrowse link
G Tlr4 toll-like receptor 4 involved_in IMP (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tlr6 toll-like receptor 6 involved_in IMP (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 5:65,109,379...65,128,387
Ensembl chr 5:65,109,374...65,117,440
JBrowse link
regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Arg2 arginase type II involved_in IMP (MGI:5810834|PMID:27214549) UniProt PMID:27214549 MGI:5810834 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075
JBrowse link
G Ccn6 cellular communication network factor 6 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr10:39,026,966...39,049,484
Ensembl chr10:39,026,966...39,039,790
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 involved_in ISO RGD
MGI
PMID:27279484 GO_REF:0000096 MGI:4417868 RGD:151347625 NCBI chr 1:152,675,904...152,712,741
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Pikfyve phosphoinositide kinase, FYVE type zinc finger containing involved_in ISO
IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:6103777|PMID:28779020)
MGI
GO_Central
UniProt
PMID:21873635 PMID:28779020 GO_REF:0000096 MGI:4834177 MGI:6103777 MGI:6201960 NCBI chr 1:65,225,796...65,317,855
Ensembl chr 1:65,225,842...65,317,854
JBrowse link
G Slc25a33 solute carrier family 25, member 33 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 4:149,828,493...149,858,746
Ensembl chr 4:149,828,493...149,858,734
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in IMP (MGI:5641585|PMID:25637806) UniProt PMID:25637806 MGI:5641585 NCBI chr 7:45,358,887...45,367,426
Ensembl chr 7:45,358,891...45,367,426
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) involved_in IMP (MGI:4837058|PMID:20416274) UniProt PMID:20416274 MGI:4837058 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28739
    metabolic process 11540
      biosynthetic process 5833
        reactive oxygen species biosynthetic process 72
          hydrogen peroxide biosynthetic process + 22
          hypochlorous acid biosynthetic process 1
          negative regulation of reactive oxygen species biosynthetic process + 27
          positive regulation of reactive oxygen species biosynthetic process + 28
          regulation of reactive oxygen species biosynthetic process + 61
Path 2
Term Annotations click to browse term
  biological_process 28739
    metabolic process 11540
      cellular metabolic process 9711
        reactive oxygen species metabolic process 267
          reactive oxygen species biosynthetic process 72
            hydrogen peroxide biosynthetic process + 22
            hypochlorous acid biosynthetic process 1
            negative regulation of reactive oxygen species biosynthetic process + 27
            positive regulation of reactive oxygen species biosynthetic process + 28
            regulation of reactive oxygen species biosynthetic process + 61
paths to the root