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ONTOLOGY REPORT - ANNOTATIONS

Term:reactive oxygen species biosynthetic process
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Accession:GO:1903409 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms:exact_synonym: reactive oxygen species anabolism;   reactive oxygen species biosynthesis;   reactive oxygen species formation;   reactive oxygen species synthesis
 related_synonym: ROS formation;   ROS generation;   reactive oxygen species generation


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reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor ISO RGD PMID:35788946 RGD:401793705 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 involved_in ISO (PMID:22573891) UniProt PMID:22573891 NCBI chr28:14,775,431...14,896,121
Ensembl chr28:14,788,369...14,895,978 		JBrowse link
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:2,264,120...2,284,196 JBrowse link
G LIPA lipase A, lysosomal acid type acts_upstream_of_or_within ISO (MGI:5560864|PMID:24287405) MGI PMID:24287405 MGI:5560864 NCBI chr26:38,892,771...38,918,441
Ensembl chr26:38,893,337...38,918,436 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO RGD PMID:21275845 RGD:41404729 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458 		JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,658,692...4,682,667
Ensembl chr 9:4,658,090...4,679,096 		JBrowse link
G CYBA cytochrome b-245 alpha chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893 		JBrowse link
G CYBB cytochrome b-245 beta chain acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr  X:32,533,365...32,568,149
Ensembl chr  X:32,533,320...32,568,217 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3037497|PMID:14980704) MGI
Ensembl		 PMID:14980704 GO_REF:0000107 MGI:3037497 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3037497|PMID:14980704) MGI
Ensembl		 PMID:14980704 GO_REF:0000107 MGI:3037497 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:11,556,024...11,588,203
Ensembl chr30:11,556,024...11,588,202 		JBrowse link
G DUOX2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr30:11,521,833...11,541,719
Ensembl chr30:11,521,845...11,541,716 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458 		JBrowse link
G SOD1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15544046)
(MGI:2682495|PMID:14679182)		 RGD
UniProt
MGI		 PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 MGI:2682495 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
hypochlorous acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPO myeloperoxidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1333719|PMID:10085024) MGI
Ensembl		 PMID:10085024 GO_REF:0000107 MGI:1333719 NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr 9:47,474,488...47,490,951
Ensembl chr 9:47,473,901...47,490,252 		JBrowse link
G CYCS cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr14:38,579,446...38,581,983
Ensembl chr14:38,579,446...38,581,983 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541 		JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr 6:28,385,199...28,393,560 JBrowse link
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr35:20,673,830...20,683,824
Ensembl chr35:20,673,839...20,683,824 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in ISO PMID:31511561 UniProt PMID:31511561 RGD:126781736 NCBI chr  X:58,305,804...58,470,827
Ensembl chr  X:58,306,776...58,471,417 		JBrowse link
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:121,545,690...121,564,117
Ensembl chr  X:121,545,586...121,563,186 		JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:14,015,093...14,084,362
Ensembl chr27:14,015,091...14,163,312 		JBrowse link
G ADCY10 adenylate cyclase 10 ISO RGD PMID:32664470 RGD:329347825 NCBI chr 7:30,576,445...30,660,926
Ensembl chr 7:30,577,591...30,660,926 		JBrowse link
G ATP5MC1 ATP synthase membrane subunit c locus 1 ISO RGD PMID:22209705 RGD:13800744 NCBI chr 9:25,123,194...25,125,959
Ensembl chr 9:25,123,241...25,127,909 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO RGD PMID:18292530 RGD:11341712 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095 		JBrowse link
G COA8 cytochrome c oxidase assembly factor 8 involved_in ISO (PMID:25175347) UniProt PMID:25175347 NCBI chr 8:71,324,271...71,357,468
Ensembl chr 8:71,318,244...71,357,466 		JBrowse link
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr 9:47,474,488...47,490,951
Ensembl chr 9:47,473,901...47,490,252 		JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:23041468 RGD:10401126 NCBI chr12:35,576,576...35,581,339
Ensembl chr12:35,576,576...35,581,230 		JBrowse link
G HBP1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) BHF-UCL PMID:24675724 MGI:5754467 NCBI chr18:13,339,359...13,368,105
Ensembl chr18:13,340,287...13,367,915 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO RGD PMID:26071548 RGD:401793712 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:22547655 RGD:10402548 NCBI chr37:7,010,421...7,025,912 JBrowse link
G INS insulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:28483668 RGD:12910717 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225 		JBrowse link
G MIR140 microRNA mir-140 ISO RGD PMID:32519270 RGD:329347827 NCBI chr 5:79,814,256...79,814,316
Ensembl chr 5:79,814,246...79,814,326 		JBrowse link
G MIR181A-1 microRNA mir-181a-1 involved_in ISO (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 7:4,055,465...4,055,526
Ensembl chr 7:4,055,465...4,055,526 		JBrowse link
G MIR181A-2 microRNA mir-181a-2 involved_in ISO (PMID:23516523) ARUK-UCL PMID:23516523 NCBI chr 9:58,302,547...58,302,606
Ensembl chr 9:58,302,547...58,302,606 		JBrowse link
G MIR590 microRNA mir-590 involved_in ISO (PMID:26648441) BHF-UCL PMID:26648441 NCBI chr 6:6,186,538...6,186,598
Ensembl chr 6:6,186,538...6,186,598 		JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 ISO RGD PMID:26888427 RGD:11040458 NCBI chr21:20,748,452...20,758,236 JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in ISO (MGI:5908331|PMID:22611253) UniProt PMID:22611253 MGI:5908331 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha acts_upstream_of ISO (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr10:19,934,020...20,006,096
Ensembl chr10:19,934,165...20,006,146 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24096089 RGD:10413842 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764 		JBrowse link
G RHOA ras homolog family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:23422569 RGD:9585767 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:11,546,285...11,555,715
Ensembl chr30:11,547,014...11,555,110 		JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268)
(PMID:22814254)		 UniProt PMID:16651268 PMID:22814254 NCBI chr30:11,541,849...11,546,019
Ensembl chr30:11,542,078...11,545,811 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225 		JBrowse link
G NOX4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,085,069...38,095,012
Ensembl chr 6:38,085,231...38,097,678 		JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:28386847 RGD:329337357 NCBI chr 7:30,576,445...30,660,926
Ensembl chr 7:30,577,591...30,660,926 		JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15450084 RGD:2313867 NCBI chr 5:32,026,193...32,038,698
Ensembl chr 5:31,882,501...32,038,119 		JBrowse link
G CD36 CD36 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3663198|PMID:16522634) MGI
Ensembl		 PMID:16522634 GO_REF:0000107 MGI:3663198 NCBI chr25:20,528,708...20,616,687
Ensembl chr25:20,528,699...20,615,070 		JBrowse link
G CYBA cytochrome b-245 alpha chain involved_in ISO (PMID:22423966) UniProt PMID:22423966 NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893 		JBrowse link
G FOXO3 forkhead box O3 ISO RGD PMID:24278276 RGD:10402204 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994 NCBI chr 9:48,492,967...48,513,981
Ensembl chr 9:48,493,287...48,509,050 		JBrowse link
G HDAC4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chr25:49,318,621...49,545,314
Ensembl chr25:49,317,349...49,453,478 		JBrowse link
G IL4 interleukin 4 ISO RGD PMID:24073824 RGD:10402792 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225 		JBrowse link
G MIR24-1 microRNA mir-24-1 involved_in ISO (PMID:21788589) BHF-UCL PMID:21788589 NCBI chr 1:71,677,608...71,677,669
Ensembl chr 1:71,677,608...71,677,669 		JBrowse link
G MIR24-2 microRNA mir-24-2 involved_in ISO (PMID:21788589) BHF-UCL PMID:21788589 NCBI chr20:48,620,684...48,620,745
Ensembl chr20:48,620,674...48,620,745 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:21712532 RGD:9590189 NCBI chr  X:55,821,227...55,857,597
Ensembl chr  X:55,821,234...55,855,502 		JBrowse link
G PARK7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (MGI:5543357|PMID:22555455) MGI PMID:22555455 MGI:5543357 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:5300086|PMID:22041900) ARUK-UCL
Ensembl		 PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr 5:70,054,683...70,233,459
Ensembl chr 5:70,059,255...70,207,049 		JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:20,633,576...20,706,240
Ensembl chr30:20,635,400...20,690,521 		JBrowse link
G SLC5A3 solute carrier family 5 member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6414721|PMID:28128227) ARUK-UCL
Ensembl		 PMID:28128227 GO_REF:0000107 MGI:6414721 NCBI chr31:28,610,332...28,635,233
Ensembl chr31:28,610,332...28,635,233 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099 		JBrowse link
regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609 		JBrowse link
G ARG2 arginase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:41,588,051...41,619,406
Ensembl chr 8:41,588,150...41,619,402 		JBrowse link
G CCN6 cellular communication network factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:68,488,846...68,499,104
Ensembl chr12:68,478,905...68,498,049 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 ISO RGD PMID:27279484 RGD:151347625 NCBI chr 7:16,914,629...16,946,370
Ensembl chr 7:16,904,031...16,945,372 		JBrowse link
G PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:16,537,095...16,620,427
Ensembl chr37:16,541,562...16,619,554 		JBrowse link
G SLC25A33 solute carrier family 25 member 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,790,116...62,825,644
Ensembl chr 5:62,790,157...62,825,388 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,681,425...107,689,790
Ensembl chr 1:107,680,599...107,689,707 		JBrowse link
G UCP1 uncoupling protein 1 involved_in IEA
ISS		 UniProt GO_REF:0000024 GO_REF:0000104 NCBI chr19:2,254,881...2,289,902 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16829
    metabolic process 10315
      biosynthetic process 7165
        reactive oxygen species biosynthetic process 73
          hydrogen peroxide biosynthetic process + 21
          hypochlorous acid biosynthetic process 1
          negative regulation of reactive oxygen species biosynthetic process + 29
          positive regulation of reactive oxygen species biosynthetic process + 26
          regulation of reactive oxygen species biosynthetic process + 60
Path 2
Term Annotations click to browse term
  biological_process 16829
    metabolic process 10315
      cellular metabolic process 9002
        reactive oxygen species metabolic process 262
          reactive oxygen species biosynthetic process 73
            hydrogen peroxide biosynthetic process + 21
            hypochlorous acid biosynthetic process 1
            negative regulation of reactive oxygen species biosynthetic process + 29
            positive regulation of reactive oxygen species biosynthetic process + 26
            regulation of reactive oxygen species biosynthetic process + 60
paths to the root