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ONTOLOGY REPORT - ANNOTATIONS

Term:reactive oxygen species biosynthetic process
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Accession:GO:1903409 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms:exact_synonym: reactive oxygen species anabolism;   reactive oxygen species biosynthesis;   reactive oxygen species formation;   reactive oxygen species synthesis
 related_synonym: ROS formation;   ROS generation;   reactive oxygen species generation

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reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 involved_in ISO (PMID:22573891) UniProt PMID:22573891 NCBI chrNW_004955485:8,006,161...8,126,074
Ensembl chrNW_004955485:8,006,706...8,115,561 		JBrowse link
G Inava innate immunity activator involved_in ISO (PMID:28436939) UniProt PMID:28436939 NCBI chrNW_004955406:37,086,302...37,107,221
Ensembl chrNW_004955406:37,086,302...37,107,221 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO RGD PMID:21275845 RGD:41404729 NCBI chrNW_004955456:13,353,780...13,363,956
Ensembl chrNW_004955456:13,354,011...13,363,891 		JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in ISO (PMID:32169171) FlyBase PMID:32169171 NCBI chrNW_004955506:6,286,824...6,309,764
Ensembl chrNW_004955506:6,286,648...6,312,716 		JBrowse link
G Duox1 dual oxidase 1 involved_in ISO (PMID:19339556), (PMID:22814254) UniProt PMID:19339556 PMID:22814254 NCBI chrNW_004955409:8,228,754...8,256,575
Ensembl chrNW_004955409:8,229,199...8,255,003 		JBrowse link
G Duox2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chrNW_004955409:8,270,657...8,288,201
Ensembl chrNW_004955409:8,271,164...8,287,096 		JBrowse link
G LOC102004641 cytochrome b-245 light chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118 		JBrowse link
G LOC102010322 cytochrome P450 1A2 acts_upstream_of_or_within ISO (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chrNW_004955450:3,165,107...3,171,894
Ensembl chrNW_004955450:3,165,106...3,171,942 		JBrowse link
G LOC102010850 cytochrome P450 1A1 acts_upstream_of_or_within ISO (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488 		JBrowse link
G LOC102012042 cytochrome b-245 heavy chain acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chrNW_004955587:781,533...818,149
Ensembl chrNW_004955587:781,388...819,912 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chrNW_004955456:13,353,780...13,363,956
Ensembl chrNW_004955456:13,354,011...13,363,891 		JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in		 ISO (MGI:2682495|PMID:14679182)
(PMID:15544046)		 RGD
MGI
UniProt		 PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 MGI:2682495 RGD:1581090 RGD:1601266 RGD:634854 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727 		JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
hypochlorous acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase acts_upstream_of_or_within ISO (MGI:1333719|PMID:10085024) MGI PMID:10085024 MGI:1333719 NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chrNW_004955467:13,151,663...13,169,005
Ensembl chrNW_004955467:13,151,957...13,168,696 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chrNW_004955411:36,403,156...36,597,660
Ensembl chrNW_004955411:36,401,842...36,512,054 		JBrowse link
G LOC102023786 cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chrNW_004955410:27,086,405...27,089,255
Ensembl chrNW_004955410:27,086,405...27,089,255 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:269,382...313,056 JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004955483:4,495,257...4,503,377 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISO PMID:31511561 UniProt PMID:31511561 RGD:126781736 NCBI chrNW_004955562:1,079,884...1,220,806
Ensembl chrNW_004955562:1,077,198...1,221,061 		JBrowse link
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:3836690|PMID:18723473), (MGI:5464985|PMID:22521832), (MGI:5790173|PMID:25583114) UniProt PMID:18723473 PMID:22521832 PMID:25583114 MGI:3836690 MGI:5464985 MGI:5790173 NCBI chrNW_004955580:459,715...475,363
Ensembl chrNW_004955580:459,715...475,774 		JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 involved_in ISO (MGI:3836690|PMID:18723473) UniProt PMID:18723473 MGI:3836690 NCBI chrNW_004955505:717,800...769,702
Ensembl chrNW_004955505:721,222...798,470 		JBrowse link
G Apopt1 apoptogenic 1, mitochondrial involved_in ISO (PMID:25175347) UniProt PMID:25175347 NCBI chrNW_004955538:2,415,781...2,432,742
Ensembl chrNW_004955538:2,415,604...2,434,658 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 ISO RGD PMID:22209705 RGD:13800744 NCBI chrNW_004955451:12,426,309...12,429,460
Ensembl chrNW_004955451:12,426,309...12,429,395 		JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO RGD PMID:18292530 RGD:11341712 NCBI chrNW_004955403:415,092...442,214
Ensembl chrNW_004955403:412,632...434,741 		JBrowse link
G Ctns cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chrNW_004955467:13,151,663...13,169,005
Ensembl chrNW_004955467:13,151,957...13,168,696 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:23041468 RGD:10401126 NCBI chrNW_004955493:8,661,317...8,663,190 JBrowse link
G Hbp1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) BHF-UCL PMID:24675724 MGI:5754467 NCBI chrNW_004955410:11,626,743...11,652,343
Ensembl chrNW_004955410:11,626,743...11,652,343 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:22547655 RGD:10402548 NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419 		JBrowse link
G Ins insulin involved_in ISO (PMID:19188609) ARUK-UCL PMID:19188609 NCBI chrNW_004955422:13,909,408...13,910,419
Ensembl chrNW_004955422:13,909,407...13,910,419 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:28483668 RGD:12910717 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772 		JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 ISO RGD PMID:26888427 RGD:11040458 NCBI chrNW_004955414:13,867,880...13,878,040 JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (MGI:5908331|PMID:22611253) UniProt PMID:22611253 MGI:5908331 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha acts_upstream_of ISO (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24096089 RGD:10413842 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152 		JBrowse link
G Rhoa ras homolog family member A involved_in ISO (MGI:5640904|PMID:25398325) CACAO PMID:25398325 MGI:5640904 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451 		JBrowse link
G Sirt1 sirtuin 1 ISO RGD PMID:23422569 RGD:9585767 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Slc30a10 solute carrier family 30 member 10 involved_in ISO (PMID:22427991) UniProt PMID:22427991 NCBI chrNW_004955520:3,631,192...3,641,595 JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) UniProt PMID:22814254 NCBI chrNW_004955409:8,256,707...8,266,891
Ensembl chrNW_004955409:8,256,707...8,266,891 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268)
(PMID:22814254)		 UniProt PMID:16651268 PMID:22814254 NCBI chrNW_004955409:8,266,873...8,270,486
Ensembl chrNW_004955409:8,266,873...8,270,486 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772 		JBrowse link
G Nox4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chrNW_004955414:4,062,337...4,220,032
Ensembl chrNW_004955414:4,062,081...4,212,746 		JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Znf205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:14,242,239...14,249,276
Ensembl chrNW_004955442:14,242,423...14,249,309 		JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 involved_in ISO (PMID:26838550) UniProt PMID:26838550 NCBI chrNW_004955454:1,250,261...1,313,547
Ensembl chrNW_004955454:1,237,363...1,314,127 		JBrowse link
G Cd36 CD36 molecule involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 acts_upstream_of_or_within ISO (MGI:3663198|PMID:16522634) MGI PMID:16522634 MGI:3663198 NCBI chrNW_004955403:36,625,871...36,710,201
Ensembl chrNW_004955403:36,625,770...36,710,201 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:24278276 RGD:10402204 NCBI chrNW_004955411:33,655,958...33,770,829
Ensembl chrNW_004955411:33,655,958...33,770,829 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994 NCBI chrNW_004955513:5,154,864...5,178,636
Ensembl chrNW_004955513:5,154,864...5,178,636 		JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chrNW_004955542:1,629,691...1,886,160
Ensembl chrNW_004955542:1,629,691...1,886,210 		JBrowse link
G Il4 interleukin 4 ISO RGD PMID:24073824 RGD:10402792 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G LOC102004641 cytochrome b-245 light chain involved_in ISO (PMID:22423966) UniProt PMID:22423966 NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in ISO (MGI:6201889|PMID:25049354) ARUK-UCL PMID:25049354 MGI:6201889 NCBI chrNW_004955412:5,928,997...5,939,012
Ensembl chrNW_004955412:5,928,997...5,939,012 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:21712532 RGD:9590189 NCBI chrNW_004955475:11,062,258...11,112,252
Ensembl chrNW_004955475:11,062,076...11,114,169 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (MGI:5543357|PMID:22555455) MGI PMID:22555455 MGI:5543357 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
G Plcg2 phospholipase C gamma 2 acts_upstream_of ISO (MGI:5300086|PMID:22041900) ARUK-UCL PMID:22041900 MGI:5300086 NCBI chrNW_004955522:4,352,890...4,480,735
Ensembl chrNW_004955522:4,358,233...4,468,986 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:24404184) UniProt PMID:24404184 NCBI chrNW_004955409:588,725...621,874
Ensembl chrNW_004955409:588,254...621,874 		JBrowse link
G Slc5a3 solute carrier family 5 member 3 acts_upstream_of_or_within ISO (MGI:6414721|PMID:28128227) ARUK-UCL PMID:28128227 MGI:6414721 NCBI chrNW_004955407:33,460,238...33,511,889
Ensembl chrNW_004955407:33,494,816...33,511,968 		JBrowse link
G Tlr4 toll like receptor 4 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942 		JBrowse link
regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISO (PMID:26210919) UniProt PMID:26210919 NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909 		JBrowse link
G Arg2 arginase 2 involved_in ISO (MGI:5810834|PMID:27214549) UniProt PMID:27214549 MGI:5810834 NCBI chrNW_004955466:2,549,557...2,577,060
Ensembl chrNW_004955466:2,549,557...2,577,060 		JBrowse link
G Ccn6 cellular communication network factor 6 involved_in ISO (PMID:27252383) UniProt PMID:27252383 NCBI chrNW_004955526:4,501,331...4,525,866
Ensembl chrNW_004955526:4,502,654...4,522,259 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO RGD PMID:27279484 RGD:151347625 NCBI chrNW_004955406:22,355,717...22,384,746
Ensembl chrNW_004955406:22,355,724...22,384,864 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO (PMID:28779020)
(MGI:6103777|PMID:28779020)		 UniProt PMID:28779020 MGI:6103777 NCBI chrNW_004955457:6,749,226...6,841,855
Ensembl chrNW_004955457:6,748,534...6,842,489 		JBrowse link
G Slc25a33 solute carrier family 25 member 33 involved_in ISO (PMID:20453889) UniProt PMID:20453889 NCBI chrNW_004955486:3,905,001...3,921,501
Ensembl chrNW_004955486:3,905,001...3,921,505 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:5641585|PMID:25637806) UniProt PMID:25637806 MGI:5641585 NCBI chrNW_004955559:1,921,479...1,929,450
Ensembl chrNW_004955559:1,917,301...1,928,493 		JBrowse link
G Ucp1 uncoupling protein 1 involved_in ISO (MGI:4837058|PMID:20416274) UniProt PMID:20416274 MGI:4837058 NCBI chrNW_004955428:3,253,363...3,282,518
Ensembl chrNW_004955428:3,274,810...3,283,237 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12199
    metabolic process 7783
      biosynthetic process 3944
        reactive oxygen species biosynthetic process 63
          hydrogen peroxide biosynthetic process + 21
          hypochlorous acid biosynthetic process 1
          negative regulation of reactive oxygen species biosynthetic process + 24
          positive regulation of reactive oxygen species biosynthetic process + 22
          regulation of reactive oxygen species biosynthetic process + 52
Path 2
Term Annotations click to browse term
  biological_process 12199
    metabolic process 7783
      cellular metabolic process 6670
        reactive oxygen species metabolic process 214
          reactive oxygen species biosynthetic process 63
            hydrogen peroxide biosynthetic process + 21
            hypochlorous acid biosynthetic process 1
            negative regulation of reactive oxygen species biosynthetic process + 24
            positive regulation of reactive oxygen species biosynthetic process + 22
            regulation of reactive oxygen species biosynthetic process + 52
paths to the root