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ONTOLOGY REPORT - ANNOTATIONS


Term:reactive oxygen species biosynthetic process
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Accession:GO:1903409 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms:exact_synonym: reactive oxygen species anabolism;   reactive oxygen species biosynthesis;   reactive oxygen species formation;   reactive oxygen species synthesis
 related_synonym: ROS formation;   ROS generation;   reactive oxygen species generation



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reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 involved_in ISO (PMID:22573891) UniProt PMID:22573891 NCBI chr10:98,849,000...98,986,443
Ensembl chr10:102,316,329...102,452,439
JBrowse link
G INAVA innate immunity activator involved_in ISO (PMID:28436939) UniProt PMID:28436939 NCBI chr 1:176,491,264...176,514,719
Ensembl chr 1:180,794,646...180,818,853
JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO RGD PMID:21275845 RGD:41404729 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in ISO (PMID:32169171) FlyBase PMID:32169171 NCBI chr17:69,890,817...69,928,342
Ensembl chr17:75,445,923...75,479,571
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 acts_upstream_of_or_within ISO (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 acts_upstream_of_or_within ISO (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447
JBrowse link
G DUOX1 dual oxidase 1 involved_in ISO (PMID:19339556), (PMID:22814254) UniProt PMID:19339556 PMID:22814254 NCBI chr15:24,077,557...24,113,206
Ensembl chr15:42,431,595...42,467,943
JBrowse link
G DUOX2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr15:24,040,513...24,061,758
Ensembl chr15:42,395,135...42,414,281
JBrowse link
G LOC100982531 cytochrome b-245 heavy chain acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183
JBrowse link
G LOC100986914 cytochrome b-245 light chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719
JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in
ISO (MGI:2682495|PMID:14679182)
(PMID:15544046)
RGD
MGI
UniProt
PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 MGI:2682495 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
hypochlorous acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPO myeloperoxidase acts_upstream_of_or_within ISO (MGI:1333719|PMID:10085024) MGI PMID:10085024 MGI:1333719 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr17:3,686,903...3,711,857
Ensembl chr17:3,683,575...3,708,253
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451
JBrowse link
G LOC100986481 cytochrome c ISO RGD PMID:21410437 RGD:7349317 NCBI chr 7:25,784,900...25,791,598
Ensembl chr 7:25,396,013...25,398,549
JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in ISO PMID:31511561 UniProt PMID:31511561 RGD:126781736 NCBI chr  X:64,304,101...64,407,310
Ensembl chr  X:74,418,754...74,521,726
JBrowse link
G ABCD1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:3836690|PMID:18723473), (MGI:5464985|PMID:22521832), (MGI:5790173|PMID:25583114) UniProt PMID:18723473 PMID:22521832 PMID:25583114 MGI:3836690 MGI:5464985 MGI:5790173 NCBI chr  X:143,275,165...143,295,283
Ensembl chr  X:153,162,412...153,182,424
JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 involved_in ISO (MGI:3836690|PMID:18723473) UniProt PMID:18723473 MGI:3836690 NCBI chr12:49,082,122...49,158,524
Ensembl chr12:49,941,914...50,011,140
JBrowse link
G ATP5MC1 ATP synthase membrane subunit c locus 1 ISO RGD PMID:22209705 RGD:13800744 NCBI chr17:8,641,273...8,644,395
Ensembl chr17:8,828,117...8,831,190
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO RGD PMID:18292530 RGD:11341712 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr17:3,686,903...3,711,857
Ensembl chr17:3,683,575...3,708,253
JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:23041468 RGD:10401126 NCBI chr 6:71,342,291...71,346,033
Ensembl chr 6:74,629,688...74,633,754
JBrowse link
G HBP1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) BHF-UCL PMID:24675724 MGI:5754467 NCBI chr 7:99,147,813...99,181,335
Ensembl chr 7:111,873,874...111,906,437
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:22547655 RGD:10402548 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959
JBrowse link
G INS insulin involved_in ISO (PMID:19188609) ARUK-UCL PMID:19188609 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G LOC100994669 cytochrome c oxidase assembly factor 8 involved_in ISO (PMID:25175347) UniProt PMID:25175347 NCBI chr14:84,189,323...84,217,230
Ensembl chr14:104,000,692...104,027,230
JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:28483668 RGD:12910717 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077
JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 ISO RGD PMID:26888427 RGD:11040458 NCBI chr11:73,128,457...73,140,344
Ensembl chr11:76,720,094...76,763,098
JBrowse link
G PAGE4 PAGE family member 4 involved_in ISO (PMID:25374899) UniProt PMID:25374899 NCBI chr  X:42,044,199...42,048,954
Ensembl chr  X:49,758,858...49,763,611
JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in ISO (MGI:5908331|PMID:22611253) UniProt PMID:22611253 MGI:5908331 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha acts_upstream_of ISO (PMID:31574452) ARUK-UCL PMID:31574452 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24096089 RGD:10413842 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
JBrowse link
G RHOA ras homolog family member A involved_in ISO (MGI:5640904|PMID:25398325) CACAO PMID:25398325 MGI:5640904 NCBI chr 3:49,282,009...49,339,887 JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:23422569 RGD:9585767 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SLC30A10 solute carrier family 30 member 10 involved_in ISO (PMID:22427991) UniProt PMID:22427991 NCBI chr 1:195,480,707...195,528,243
Ensembl chr 1:200,522,554...200,566,228
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) UniProt PMID:22814254 NCBI chr15:24,064,967...24,077,641
Ensembl chr15:42,418,234...42,430,749
JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268)
(PMID:22814254)
UniProt PMID:16651268 PMID:22814254 NCBI chr15:24,061,922...24,066,016
Ensembl chr15:42,415,195...42,418,974
JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077
JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
G ZNF205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr16:2,054,056...2,061,992
Ensembl chr16:3,233,794...3,241,216
JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in ISO (PMID:26838550) UniProt PMID:26838550 NCBI chr 8:139,154,065...139,251,115
Ensembl chr 8:142,220,827...142,301,070
JBrowse link
G CD36 CD36 molecule involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865
JBrowse link
G CLCN3 chloride voltage-gated channel 3 acts_upstream_of_or_within ISO (MGI:3663198|PMID:16522634) MGI PMID:16522634 MGI:3663198 NCBI chr 4:161,838,061...161,943,072
Ensembl chr 4:173,925,474...174,011,681
JBrowse link
G FOXO3 forkhead box O3 ISO RGD PMID:24278276 RGD:10402204 NCBI chr 6:106,360,519...106,485,676
Ensembl chr 6:110,406,266...110,516,272
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382
JBrowse link
G HDAC4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054
JBrowse link
G IL4 interleukin 4 ISO RGD PMID:24073824 RGD:10402792 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798
JBrowse link
G LOC100986914 cytochrome b-245 light chain involved_in ISO (PMID:22423966) UniProt PMID:22423966 NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719
JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077
JBrowse link
G MMP8 matrix metallopeptidase 8 involved_in ISO (MGI:6201889|PMID:25049354) ARUK-UCL PMID:25049354 MGI:6201889 NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736
JBrowse link
G MRPS6 mitochondrial ribosomal protein S6 acts_upstream_of_or_within ISO (MGI:6414721|PMID:28128227) ARUK-UCL PMID:28128227 MGI:6414721 NCBI chr21:20,441,365...20,510,800
Ensembl chr21:33,862,033...33,879,670
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:21712532 RGD:9590189 NCBI chr  X:60,798,219...60,840,948
Ensembl chr  X:70,852,687...70,894,921
JBrowse link
G PARK7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (MGI:5543357|PMID:22555455) MGI PMID:22555455 MGI:5543357 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of ISO (MGI:5300086|PMID:22041900) ARUK-UCL PMID:22041900 MGI:5300086 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064
JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in ISO (PMID:24404184) UniProt PMID:24404184 NCBI chr15:34,174,491...34,263,045
Ensembl chr15:52,498,202...52,529,984
JBrowse link
G TLR4 toll like receptor 4 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 4:33,153,151...33,174,053
Ensembl chr 4:39,009,103...39,011,490
JBrowse link
regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase involved_in ISO (PMID:26210919) UniProt PMID:26210919 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
JBrowse link
G ARG2 arginase 2 involved_in ISO (MGI:5810834|PMID:27214549) UniProt PMID:27214549 MGI:5810834 NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962
JBrowse link
G CCN6 cellular communication network factor 6 involved_in ISO (PMID:27252383) UniProt PMID:27252383 NCBI chr 6:109,863,877...109,880,480
Ensembl chr 6:113,939,975...113,955,427
JBrowse link
G PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO (PMID:28779020)
(MGI:6103777|PMID:28779020)
UniProt PMID:28779020 MGI:6103777 NCBI chr2B:95,505,376...95,597,792
Ensembl chr2B:213,628,997...213,721,299
JBrowse link
G SLC25A33 solute carrier family 25 member 33 involved_in ISO (PMID:20453889) UniProt PMID:20453889 NCBI chr 1:8,300,384...8,343,270
Ensembl chr 1:9,541,918...9,574,549
JBrowse link
G SPHK2 sphingosine kinase 2 involved_in ISO (MGI:5641585|PMID:25637806) UniProt PMID:25637806 MGI:5641585 NCBI chr19:45,620,980...45,631,786
Ensembl chr19:54,213,166...54,224,767
JBrowse link
G UCP1 uncoupling protein 1 involved_in ISO (MGI:4837058|PMID:20416274) UniProt PMID:20416274 MGI:4837058 NCBI chr 4:132,921,033...132,930,714
Ensembl chr 4:144,230,858...144,240,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12786
    metabolic process 8099
      biosynthetic process 4145
        reactive oxygen species biosynthetic process 62
          hydrogen peroxide biosynthetic process + 19
          hypochlorous acid biosynthetic process 1
          negative regulation of reactive oxygen species biosynthetic process + 24
          positive regulation of reactive oxygen species biosynthetic process + 22
          regulation of reactive oxygen species biosynthetic process + 51
Path 2
Term Annotations click to browse term
  biological_process 12786
    metabolic process 8099
      cellular metabolic process 7388
        reactive oxygen species metabolic process 227
          reactive oxygen species biosynthetic process 62
            hydrogen peroxide biosynthetic process + 19
            hypochlorous acid biosynthetic process 1
            negative regulation of reactive oxygen species biosynthetic process + 24
            positive regulation of reactive oxygen species biosynthetic process + 22
            regulation of reactive oxygen species biosynthetic process + 51
paths to the root