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ONTOLOGY REPORT - ANNOTATIONS


Term:reactive oxygen species biosynthetic process
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Accession:GO:1903409 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms:exact_synonym: reactive oxygen species anabolism;   reactive oxygen species biosynthesis;   reactive oxygen species formation;   reactive oxygen species synthesis
 related_synonym: ROS formation;   ROS generation;   reactive oxygen species generation


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reactive oxygen species biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 ISO (PMID:22573891) RGD PMID:22573891 NCBI chr 1:265,904,616...266,033,107
Ensembl chr 1:265,904,566...266,033,156
JBrowse link
G Inava innate immunity activator ISO (PMID:28436939) RGD PMID:28436939 NCBI chr13:53,088,438...53,108,713
Ensembl chr13:53,088,439...53,108,713
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 ISO
ISS
IEA
(PMID:32169171)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:32169171 GO_REF:0000024, GO_REF:0000107 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Cyba cytochrome b-245 alpha chain IMP PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain ISO MGI:MGI:1857284 (MGI:MGI:3050718|PMID:15258578) RGD PMID:15258578 MGI:MGI:3050718 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO MGI:MGI:2182307 (MGI:MGI:3037497|PMID:14980704) RGD PMID:14980704 MGI:MGI:3037497 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO MGI:MGI:2182351 (MGI:MGI:3037497|PMID:14980704) RGD PMID:14980704 MGI:MGI:3037497 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Duox1 dual oxidase 1 IEA
ISO
GO_REF:0000107
UniProtKB:Q1HG43 (PMID:19339556), (PMID:22814254)
Ensembl
RGD
PMID:19339556, PMID:22814254 GO_REF:0000107 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Duox2 dual oxidase 2 IEA
ISO
GO_REF:0000002
UniProtKB:Q1HG44 (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904)
InterPro
RGD
PMID:16651268, PMID:19339556, PMID:22814254, PMID:25761904 GO_REF:0000002 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO MGI:MGI:1934143 (MGI:MGI:3050718|PMID:15258578) RGD PMID:15258578 MGI:MGI:3050718 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Sod1 superoxide dismutase 1 IMP
ISS
ISO
IDA
GO_REF:0000024
(PMID:15544046)
MGI:MGI:1857873 (MGI:MGI:2682495|PMID:14679182)
UniProt
RGD
PMID:14679182, PMID:15544046, PMID:15880490, PMID:10640619, PMID:12514262 GO_REF:0000024, MGI:MGI:2682495, RGD:1581090, RGD:1601266, RGD:634854 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 IDA RGD PMID:15642720 RGD:2291946 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
hypochlorous acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase ISO MGI:MGI:2176344 (MGI:MGI:1333719|PMID:10085024) RGD PMID:10085024 MGI:MGI:1333719 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868
JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:3,321,488...3,359,219
Ensembl chr10:3,321,476...3,357,470
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
negative regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant ISO
IEA
MGI:MGI:2180086 (MGI:MGI:1930064|PMID:11168643)
GO_REF:0000107
RGD
Ensembl
PMID:11168643 GO_REF:0000107, MGI:MGI:1930064 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:11591728), (PMID:19278978) RGD PMID:11591728, PMID:19278978 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Cav1 caveolin 1 ISO
IEA
MGI:MGI:2180364 (MGI:MGI:2450774|PMID:12388077)
GO_REF:0000107
RGD
Ensembl
PMID:12388077 GO_REF:0000107, MGI:MGI:2450774 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cd34 CD34 molecule ISO
ISS
(PMID:17505307)
GO_REF:0000024
RGD
UniProt
PMID:17505307 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Dynll1 dynein light chain LC8-type 1 IDA PMID:8864115 MGI PMID:8864115 RGD:633683 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Epor erythropoietin receptor IMP RGD PMID:10489101 RGD:11041656 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:9519713 RGD:2303775 NCBI chr 4:78,377,228...78,386,683
Ensembl chr 4:78,378,144...78,385,577
JBrowse link
G Gla galactosidase, alpha ISO (MGI:MGI:3624267|PMID:15668341) RGD PMID:15668341 MGI:MGI:3624267 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Il10 interleukin 10 IDA RGD PMID:17017555 RGD:1598631 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il4 interleukin 4 IDA RGD PMID:18182309 RGD:2317291 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Khsrp KH-type splicing regulatory protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16126846)
Ensembl
UniProt
RGD
PMID:16126846 GO_REF:0000024, GO_REF:0000107 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO
ISS
(PMID:20525224)
GO_REF:0000024
RGD
UniProt
PMID:20525224 GO_REF:0000024 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Ptgis prostaglandin I2 synthase ISO
ISS
(PMID:20159982)
GO_REF:0000024
RGD
UniProt
PMID:20159982 GO_REF:0000024 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Rgn regucalcin IMP RGD PMID:12686401 RGD:9590175 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:6271078|PMID:29353861)
(PMID:29353861)
Ensembl
RGD
PMID:29353861 GO_REF:0000107, MGI:MGI:6271078 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Sirpa signal-regulatory protein alpha ISO
IEA
(MGI:MGI:3760575|PMID:17954568)
GO_REF:0000107
RGD
Ensembl
PMID:17954568 GO_REF:0000107, MGI:MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Tspo translocator protein IDA RGD PMID:14678758 RGD:2317158 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Wdr35 WD repeat domain 35 IDA RGD PMID:18671723 RGD:11553926 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISO
ISS
(PMID:18178554)
GO_REF:0000024
(MGI:MGI:5142149|PMID:21616078)
RGD
UniProt
PMID:18178554, PMID:21616078 GO_REF:0000024, MGI:MGI:5142149 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 ISO
ISS
(MGI:MGI:3836690|PMID:18723473), (MGI:MGI:5464985|PMID:22521832), (MGI:MGI:5790173|PMID:25583114)
GO_REF:0000024
RGD
UniProt
PMID:18723473, PMID:22521832, PMID:25583114 GO_REF:0000024, MGI:MGI:3836690, MGI:MGI:5464985, MGI:MGI:5790173 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 ISO
ISS
(MGI:MGI:3836690|PMID:18723473)
GO_REF:0000024
RGD
UniProt
PMID:18723473 GO_REF:0000024, MGI:MGI:3836690 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 IMP RGD PMID:22209705 RGD:13800744 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator IMP RGD PMID:18292530 RGD:11341712 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 ISO
ISS
(PMID:25175347)
GO_REF:0000024
RGD
UniProt
PMID:25175347 GO_REF:0000024 NCBI chr 6:136,185,772...136,210,936
NCBI chr 6:136,279,476...136,304,317
Ensembl chr 6:136,185,487...136,210,940
Ensembl chr 6:136,185,487...136,210,940
JBrowse link
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 IMP RGD PMID:23041468 RGD:10401126 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Hbp1 HMG-box transcription factor 1 ISO (MGI:MGI:5754467|PMID:24675724) RGD PMID:24675724 MGI:MGI:5754467 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IMP RGD PMID:22547655 RGD:10402548 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ins2 insulin 2 ISO ComplexPortal:CPX-1134 (PMID:19188609) RGD PMID:19188609 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:28483668 RGD:12910717 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
ISS
(MGI:MGI:5908331|PMID:22611253)
GO_REF:0000024
RGD
UniProt
PMID:22611253 GO_REF:0000024, MGI:MGI:5908331 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO (PMID:31574452) RGD PMID:31574452 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:24096089 RGD:10413842 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rhoa ras homolog family member A ISO (MGI:MGI:5640904|PMID:25398325) RGD PMID:25398325 MGI:MGI:5640904 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:23422569 RGD:9585767 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc30a10 solute carrier family 30, member 10 ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
nitric oxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B ISO (PMID:24500710) RGD PMID:24500710 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 ISO (PMID:24500710) RGD PMID:24500710 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4431324|PMID:20032512)
Ensembl
UniProt
RGD
PMID:20032512 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4431324 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Dynll1 dynein light chain LC8-type 1 TAS PMID:8864115 PINC PMID:8864115 RGD:633683 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G LOC497963 similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS) IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:66,282,171...66,313,373
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 ISO (PMID:24500710) RGD PMID:24500710 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 ISO (PMID:24500710) RGD PMID:24500710 NCBI chr13:102,724,266...102,755,511
Ensembl chr13:102,724,348...102,756,174
JBrowse link
G Nos1 nitric oxide synthase 1 IDA
IBA
ISO
IEA
PMID:21873635
(MGI:MGI:3807771|PMID:7545544), (MGI:MGI:5582183|PMID:11591728)
GO_REF:0000002
GO_REF:0000107
PMID:1383204
RGD
InterPro
Ensembl
PMID:7545544, PMID:11591728, PMID:14966111, PMID:21873635, PMID:1383204 GO_REF:0000002, GO_REF:0000107, MGI:MGI:3807771, MGI:MGI:5582183, RGD:1358520, RGD:13792537, RGD:8553334 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 IDA
IBA
ISO
IEA
TAS
PMID:21873635
(MGI:MGI:3807769|PMID:9271491), (MGI:MGI:3807772|PMID:1383204)
(PMID:7504305), (PMID:7682706)
GO_REF:0000107
PMID:9851365
RGD
Ensembl
PMID:1383204, PMID:7504305, PMID:7682706, PMID:9271491, PMID:12826065, PMID:21873635, PMID:9851365, PMID:16172396 GO_REF:0000107, MGI:MGI:3807769, MGI:MGI:3807772, RGD:1358527, RGD:13792537, RGD:8656011, RGD:1580262 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 IMP
IBA
ISO
IEA
IEP
PMID:21873635
(PMID:1378832), (PMID:7488039)
GO_REF:0000107
MGI:MGI:1857229 (MGI:MGI:3576391|PMID:15647265)
RGD
Ensembl
PMID:1378832, PMID:7488039, PMID:15647265, PMID:12388111, PMID:21873635, PMID:16344378 GO_REF:0000107, MGI:MGI:3576391, RGD:628542, RGD:13792537, RGD:7794722 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G P2rx4 purinergic receptor P2X 4 ISO MGI:MGI:3612982 (MGI:MGI:3612001|PMID:16327800) RGD PMID:16327800 MGI:MGI:3612001 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G Rora RAR-related orphan receptor A ISO MGI:MGI:1857035 (MGI:MGI:66348|PMID:7518067) RGD PMID:7518067 MGI:MGI:66348 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Slc7a2 solute carrier family 7 member 2 ISO MGI:MGI:2150359 (MGI:MGI:2656016|PMID:12675924) RGD PMID:12675924 MGI:MGI:2656016 NCBI chr16:54,459,409...54,513,349
Ensembl chr16:54,460,067...54,513,349
JBrowse link
G Spr sepiapterin reductase ISO (PMID:15197144) RGD PMID:15197144 NCBI chr 4:116,912,343...116,916,073
Ensembl chr 4:116,912,351...116,916,236
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:114,241,057...114,251,720
Ensembl chr 3:114,241,057...114,251,647
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268, PMID:22814254 NCBI chr 3:114,236,718...114,240,086
Ensembl chr 3:114,236,718...114,240,086
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Zfp13 zinc finger protein 13 ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,908,643...12,916,784
Ensembl chr10:12,908,643...12,916,784
JBrowse link
positive regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:17616753 RGD:8548892 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 ISO
IBA
(PMID:20018850)
PMID:21873635
RGD PMID:20018850, PMID:21873635 RGD:13792537 NCBI chr 2:60,337,667...60,379,144
Ensembl chr 2:60,337,667...60,379,420
JBrowse link
G Aif1 allograft inflammatory factor 1 IDA
IMP
RGD PMID:16157606, PMID:16157606 RGD:2313017, RGD:2313017 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:10376603) RGD PMID:10376603 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IMP RGD PMID:18335029 RGD:2313325 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:O00206|UniProtKB:P16671|UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ass1 argininosuccinate synthase 1 ISO (PMID:21106532) RGD PMID:21106532 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Cd36 CD36 molecule ISO UniProtKB:P05067:PRO_0000000092 (MGI:MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:MGI:4438693 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Clec7a C-type lectin domain containing 7A ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Clu clusterin ISO
ISS
IEA
(PMID:15857407)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:15857407 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Crp C-reactive protein IDA RGD PMID:9767445 RGD:9586000 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 IMP
IBA
ISO
PMID:21873635
(MGI:MGI:5315329|PMID:21493890)
RGD PMID:21493890, PMID:12237779, PMID:21873635 MGI:MGI:5315329, RGD:727432, RGD:13792537 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:16973909 RGD:9685181 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Esr1 estrogen receptor 1 ISO
ISS
(PMID:21937726)
GO_REF:0000024
RGD
UniProt
PMID:21937726 GO_REF:0000024 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Hrh1 histamine receptor H 1 IDA RGD PMID:12419527 RGD:727463 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO
ISS
(MGI:MGI:3687888|PMID:12855682)
GO_REF:0000024
RGD
UniProt
PMID:12855682 GO_REF:0000024, MGI:MGI:3687888 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Icam1 intercellular adhesion molecule 1 IMP RGD PMID:9062344 RGD:1600239 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:1930064|PMID:11168643)
(PMID:8383325)
RGD PMID:8383325, PMID:11168643 MGI:MGI:1930064 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta ISO
IEA
(PMID:8383325)
GO_REF:0000107
RGD
Ensembl
PMID:8383325 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 IDA RGD PMID:15845578 RGD:2306941 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor ISO
IEA
(PMID:10747347)
GO_REF:0000107
RGD
Ensembl
PMID:10747347 GO_REF:0000107 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Itgb2 integrin subunit beta 2 IMP RGD PMID:9062344 RGD:1600239 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:12595539 RGD:1641934 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Klf2 Kruppel-like factor 2 ISO (PMID:21768538) RGD PMID:21768538 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Klf4 Kruppel like factor 4 ISO (PMID:22430140) RGD PMID:22430140 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klrk1 killer cell lectin like receptor K1 ISO
IEA
(MGI:MGI:2450811|PMID:12645935)
GO_REF:0000107
RGD
Ensembl
PMID:12645935 GO_REF:0000107, MGI:MGI:2450811 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like ISO MGI:MGI:3701255 (MGI:MGI:3700871|PMID:16476767) RGD PMID:16476767 MGI:MGI:3700871 NCBI chr20:3,242,236...3,253,995
Ensembl chr20:3,242,470...3,249,189
JBrowse link
G LOC103692716 heat shock protein HSP 90-alpha ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:135,044,833...135,050,417
Ensembl chr 6:135,045,363...135,049,728
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mir29b1 microRNA 29b-1 IMP RGD PMID:29374012 RGD:13702880 NCBI chr 4:58,344,310...58,344,390
Ensembl chr 4:58,344,310...58,344,390
JBrowse link
G Mmp8 matrix metallopeptidase 8 IEA
ISO
IMP
GO_REF:0000107
(MGI:MGI:6201889|PMID:25049354)
Ensembl
RGD
PMID:25049354, PMID:25049354 GO_REF:0000107, MGI:MGI:6201889, RGD:13792525 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:19576187 RGD:10041012 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO (PMID:20214800) RGD PMID:20214800 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (PMID:19265036)
(MGI:MGI:5315687|PMID:19265036)
RGD PMID:19265036 MGI:MGI:5315687 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:21926342 RGD:10041069 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptx3 pentraxin 3 ISO (MGI:MGI:3037598|PMID:14726497) RGD PMID:14726497 MGI:MGI:3037598 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:1,814,661...1,833,033
Ensembl chr20:1,814,661...1,818,800
JBrowse link
G Smad3 SMAD family member 3 IGI
ISO
PMID:27038547
(PMID:27038547)
RGD PMID:27038547, PMID:27038547 RGD:11535100 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:14720208 RGD:10042970 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sod2 superoxide dismutase 2 ISO MGI:MGI:1857480 (MGI:MGI:3577668|PMID:15637112) RGD PMID:15637112 MGI:MGI:3577668 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 ISO MGI:MGI:2679794 (MGI:MGI:2670551|PMID:12872135) RGD PMID:12872135 MGI:MGI:2670551 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tlr2 toll-like receptor 2 ISO MGI:MGI:2178675 (MGI:MGI:2178646|PMID:10549626), (MGI:MGI:3611539|PMID:16239543) RGD PMID:10549626, PMID:16239543 MGI:MGI:2178646, MGI:MGI:3611539 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 IEA
ISO
GO_REF:0000107
MGI:MGI:1860885|UniProtKB:P05067:PRO_0000000092 (MGI:MGI:2178646|PMID:10549626), (MGI:MGI:4438693|PMID:20037584)
Ensembl
RGD
PMID:10549626, PMID:20037584 GO_REF:0000107, MGI:MGI:2178646, MGI:MGI:4438693 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr5 toll-like receptor 5 IDA RGD PMID:16973131 RGD:1643119 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764
JBrowse link
G Tlr6 toll-like receptor 6 ISO UniProtKB:O00206|UniProtKB:P05067:PRO_0000000092|UniProtKB:P16671 (MGI:MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:MGI:4438693 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
G Tnf tumor necrosis factor ISO (PMID:8383325) RGD PMID:8383325 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:16081483 RGD:2317115 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ulbp1 UL16 binding protein 1 ISO (MGI:MGI:2450811|PMID:12645935) RGD PMID:12645935 MGI:MGI:2450811 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916
JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 ISO (PMID:26838550) RGD PMID:26838550 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Cd36 CD36 molecule ISO (MGI:MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:MGI:4438693 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Clcn3 chloride voltage-gated channel 3 ISO MGI:MGI:2447864 (MGI:MGI:3663198|PMID:16522634) RGD PMID:16522634 MGI:MGI:3663198 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Cyba cytochrome b-245 alpha chain ISO (PMID:22423966) RGD PMID:22423966 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Foxo3 forkhead box O3 IMP RGD PMID:24278276 RGD:10402204 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IGI PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Hdac4 histone deacetylase 4 IMP RGD PMID:24166750 RGD:9681442 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Il4 interleukin 4 IDA RGD PMID:24073824 RGD:10402792 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO (MGI:MGI:6201889|PMID:25049354) RGD PMID:25049354 MGI:MGI:6201889 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase IMP RGD PMID:21712532 RGD:9590189 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
G Park7 Parkinsonism associated deglycase ISO (MGI:MGI:5543357|PMID:22555455) RGD PMID:22555455 MGI:MGI:5543357 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Rab27a RAB27A, member RAS oncogene family ISO (PMID:24404184) RGD PMID:24404184 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Slc5a3 solute carrier family 5 member 3 ISO (MGI:MGI:6414721|PMID:28128227) RGD PMID:28128227 MGI:MGI:6414721 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Tlr4 toll-like receptor 4 ISO (MGI:MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:MGI:4438693 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr6 toll-like receptor 6 ISO (MGI:MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:MGI:4438693 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 IEP RGD PMID:11829529 RGD:634667 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Cd47 Cd47 molecule IEA
ISO
GO_REF:0000107
(MGI:MGI:6201986|PMID:16055727)
Ensembl
RGD
PMID:16055727 GO_REF:0000107, MGI:MGI:6201986 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO UniProtKB:P05067 (MGI:MGI:6162390|PMID:23499256) RGD PMID:23499256 MGI:MGI:6162390 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator NAS RGD PMID:8702680 RGD:728623 NCBI chr 3:110,975,923...110,979,957
Ensembl chr 3:110,975,923...110,979,957
JBrowse link
G Igf1 insulin-like growth factor 1 ISO MGI:MGI:2386329|MGI:MGI:2389580 (MGI:MGI:5433272|PMID:21677284) RGD PMID:21677284 MGI:MGI:5433272 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Jak2 Janus kinase 2 IGI PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein TAS PMID:20431962 DFLAT PMID:20431962 RGD:8553554 NCBI chr13:88,653,123...88,943,976 JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO (MGI:MGI:3810237|PMID:17698736) RGD PMID:17698736 MGI:MGI:3810237 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Rac1 Rac family small GTPase 1 IGI PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Sirpa signal-regulatory protein alpha IMP PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO
IEA
ISS
(PMID:26210919)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26210919 GO_REF:0000024, GO_REF:0000107 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Arg2 arginase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:5810834|PMID:27214549)
Ensembl
RGD
PMID:27214549 GO_REF:0000107, MGI:MGI:5810834 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Ccn6 cellular communication network factor 6 ISO (PMID:27252383) RGD PMID:27252383 NCBI chr20:44,237,491...44,255,064
Ensembl chr20:44,237,491...44,255,064
JBrowse link
G LOC100909612 mitochondrial brown fat uncoupling protein 1-like IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr19:29,395,702...29,400,389
Ensembl chr19:29,396,157...29,400,355
JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing ISO
IEA
(PMID:28779020)
(MGI:MGI:6103777|PMID:28779020)
GO_REF:0000107
RGD
Ensembl
PMID:28779020 GO_REF:0000107, MGI:MGI:6103777 NCBI chr 9:71,911,744...72,005,816
Ensembl chr 9:71,915,421...72,005,838
JBrowse link
G Slc25a33 solute carrier family 25 member 33 ISO (PMID:20453889) RGD PMID:20453889 NCBI chr 5:166,701,463...166,726,794
Ensembl chr 5:166,701,465...166,726,794
JBrowse link
G Sphk2 sphingosine kinase 2 ISO (MGI:MGI:5641585|PMID:25637806) RGD PMID:25637806 MGI:MGI:5641585 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Ucp1 uncoupling protein 1 NAS
ISO
PMID:20416274
(MGI:MGI:4837058|PMID:20416274)
RGD PMID:20416274, PMID:20416274 MGI:MGI:4837058, RGD:11541111 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      biosynthetic process 6225
        reactive oxygen species biosynthetic process 141
          hydrogen peroxide biosynthetic process + 20
          hypochlorous acid biosynthetic process 1
          negative regulation of reactive oxygen species biosynthetic process + 41
          nitric oxide biosynthetic process + 88
          positive regulation of reactive oxygen species biosynthetic process + 66
          regulation of reactive oxygen species biosynthetic process + 117
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        reactive oxygen species metabolic process 310
          reactive oxygen species biosynthetic process 141
            hydrogen peroxide biosynthetic process + 20
            hypochlorous acid biosynthetic process 1
            negative regulation of reactive oxygen species biosynthetic process + 41
            nitric oxide biosynthetic process + 88
            positive regulation of reactive oxygen species biosynthetic process + 66
            regulation of reactive oxygen species biosynthetic process + 117
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.