ONTOLOGY REPORT - ANNOTATIONS
Term: reactive oxygen species biosynthetic process
Accession: GO:1903409
browse the term
Definition: The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
Synonyms: exact_synonym: reactive oxygen species anabolism; reactive oxygen species biosynthesis; reactive oxygen species formation; reactive oxygen species synthesis
related_synonym: ROS formation; ROS generation; reactive oxygen species generation
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Abcc9
ATP binding cassette subfamily C member 9
acts_upstream_of_or_within involved_in
ISO IEA
MGI:2155916 (PMID:20935152) GO_REF:0000107
RGD Ensembl
PMID:20935152
GO_REF:0000107
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
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Ahr
aryl hydrocarbon receptor
IMP
RGD
PMID:35788946
RGD:401793705
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Dmd
dystrophin
acts_upstream_of_or_within
ISO
MGI:1856328 (PMID:20716577)
RGD
PMID:20716577
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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Gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
involved_in
ISO
(PMID:22573891)
RGD
PMID:22573891
NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042
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Inava
innate immunity activator
involved_in
ISO
(PMID:28436939)
RGD
PMID:28436939
NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729
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Lipa
lipase A, lysosomal acid type
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2451080 (PMID:24287405)
Ensembl RGD
PMID:24287405
GO_REF:0000107
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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Ncf1
neutrophil cytosolic factor 1
IMP
RGD
PMID:21275845
RGD:41404729
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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Acox1
acyl-CoA oxidase 1
involved_in
IEA ISS ISO
GO_REF:0000107 GO_REF:0000024 (PMID:32169171)
Ensembl UniProt RGD
PMID:32169171
GO_REF:0000024 GO_REF:0000107
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Cyba
cytochrome b-245 alpha chain
involved_in
IMP
PMID:8798532
BHF-UCL
PMID:8798532
RGD:2317869
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Cybb
cytochrome b-245 beta chain
acts_upstream_of_or_within
ISO
MGI:1857284 (PMID:15258578)
RGD
PMID:15258578
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
acts_upstream_of_or_within
ISO
MGI:2182307 (PMID:14980704)
RGD
PMID:14980704
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2182351 (PMID:14980704)
Ensembl RGD
PMID:14980704
GO_REF:0000107
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Duox1
dual oxidase 1
involved_in
ISO IEA
UniProtKB:Q1HG43 (PMID:19339556), (PMID:22814254) GO_REF:0000107
RGD Ensembl
PMID:19339556 PMID:22814254
GO_REF:0000107
NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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Duox2
dual oxidase 2
involved_in
ISO
UniProtKB:Q1HG44 (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904)
RGD
PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904
NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
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Ncf1
neutrophil cytosolic factor 1
acts_upstream_of_or_within
ISO
MGI:1934143 (PMID:15258578)
RGD
PMID:15258578
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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Sod1
superoxide dismutase 1
acts_upstream_of_or_within involved_in
IMP ISO IEA ISS IDA
MGI:1857873 (PMID:14679182) GO_REF:0000107 (PMID:15544046) GO_REF:0000024
RGD Ensembl UniProt
PMID:14679182 PMID:15544046 PMID:15880490 PMID:12514262 PMID:10640619
GO_REF:0000024 GO_REF:0000107, RGD:1581090 , RGD:634854 , RGD:1601266
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
IDA
RGD
PMID:15642720
RGD:2291946
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Mpo
myeloperoxidase
acts_upstream_of_or_within
ISO
MGI:2176344 (PMID:10085024)
RGD
PMID:10085024
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Ctns
cystinosin, lysosomal cystine transporter
IMP
RGD
PMID:26482480
RGD:12910938
NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
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Cycs
cytochrome c, somatic
IMP
RGD
PMID:21410437
RGD:7349317
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Fyn
FYN proto-oncogene, Src family tyrosine kinase
involved_in
IMP
PMID:27525436
ARUK-UCL
PMID:27525436
RGD:13601987
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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Mpv17l
MPV17 mitochondrial inner membrane protein like
involved_in
ISO
(PMID:22306510)
RGD
PMID:22306510
NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649
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Prl
prolactin
involved_in
ISO
(PMID:24530842)
RGD
PMID:24530842
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Stat3
signal transducer and activator of transcription 3
IMP
RGD
PMID:23590160
RGD:8694322
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Abcb7
ATP binding cassette subfamily B member 7
involved_in
IMP
PMID:31511561
UniProt
PMID:31511561
RGD:126781736
NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858
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Abcd1
ATP binding cassette subfamily D member 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:18723473), (PMID:22521832), (PMID:25583114) (MGI:3836690|PMID:18723473), (MGI:5464985|PMID:22521832), (MGI:5790173|PMID:25583114)
UniProt RGD
PMID:18723473 PMID:22521832 PMID:25583114
GO_REF:0000024 MGI:3836690 MGI:5464985 MGI:5790173
NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115
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Abcd2
ATP binding cassette subfamily D member 2
involved_in
ISS ISO
GO_REF:0000024 (MGI:3836690|PMID:18723473)
UniProt RGD
PMID:18723473
GO_REF:0000024 MGI:3836690
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
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Adcy10
adenylate cyclase 10
IMP
RGD
PMID:32664470
RGD:329347825
NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
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Atp5mc1
ATP synthase membrane subunit c locus 1
IMP
RGD
PMID:22209705
RGD:13800744
NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124 Ensembl chr10:81,023,925...81,027,124
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Cflar
CASP8 and FADD-like apoptosis regulator
IMP
RGD
PMID:18292530
RGD:11341712
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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Coa8
cytochrome c oxidase assembly factor 8
involved_in
ISO ISS
(PMID:25175347) GO_REF:0000024
RGD UniProt
PMID:25175347
GO_REF:0000024
NCBI chr 6:130,772,218...130,797,081
Ensembl chr 6:130,771,199...130,797,081
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Ctns
cystinosin, lysosomal cystine transporter
IMP
RGD
PMID:26482480
RGD:12910938
NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
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Eef1a1
eukaryotic translation elongation factor 1 alpha 1
IMP
RGD
PMID:23041468
RGD:10401126
NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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Hbp1
HMG-box transcription factor 1
involved_in
ISO
(MGI:5754467|PMID:24675724) (PMID:24675724)
RGD
PMID:24675724
MGI:5754467
NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
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Hif1a
hypoxia inducible factor 1 subunit alpha
IMP
RGD
PMID:26071548
RGD:401793712
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hspd1
heat shock protein family D (Hsp60) member 1
IMP
RGD
PMID:22547655
RGD:10402548
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Ins2
insulin 2
involved_in
ISO
ComplexPortal:CPX-1134 (PMID:19188609)
RGD
PMID:19188609
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Mfn2
mitofusin 2
IMP
RGD
PMID:28483668
RGD:12910717
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mir140
microRNA 140
IMP
RGD
PMID:32519270
RGD:329347827
NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
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Mir181a2
microRNA 181a-2
involved_in
ISO
(PMID:23516523)
RGD
PMID:23516523
NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
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Ndufc2
NADH:ubiquinone oxidoreductase subunit C2
IMP
RGD
PMID:26888427
RGD:11040458
NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
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Park7
Parkinsonism associated deglycase
involved_in
ISS ISO
GO_REF:0000024 (PMID:22611253) (MGI:5908331|PMID:22611253)
UniProt RGD
PMID:22611253
GO_REF:0000024 MGI:5908331
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Ppara
peroxisome proliferator activated receptor alpha
acts_upstream_of
ISO
(PMID:31574452)
RGD
PMID:31574452
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Prkn
parkin RBR E3 ubiquitin protein ligase
IMP
RGD
PMID:24096089
RGD:10413842
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Ptgr1
prostaglandin reductase 1
IDA
RGD
PMID:9667737
RGD:401959219
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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Rhoa
ras homolog family member A
involved_in
ISO
(MGI:5640904|PMID:25398325) (PMID:25398325)
RGD
PMID:25398325
MGI:5640904
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Sirt1
sirtuin 1
IMP
RGD
PMID:23422569
RGD:9585767
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Duoxa1
dual oxidase maturation factor 1
involved_in
ISO
(PMID:22814254)
RGD
PMID:22814254
NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
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Duoxa2
dual oxidase maturation factor 2
involved_in
ISO
(PMID:16651268), (PMID:22814254)
RGD
PMID:16651268 PMID:22814254
NCBI chr 3:109,245,337...109,249,055
Ensembl chr 3:109,245,476...109,248,968
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Mfn2
mitofusin 2
IMP
RGD
PMID:27997345
RGD:12910740
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Nox4
NADPH oxidase 4
IMP
RGD
PMID:27279484
RGD:151347625
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Sod2
superoxide dismutase 2
IMP
RGD
PMID:20529999
RGD:27095884
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Zfp13
zinc finger protein 13
involved_in
ISO
(PMID:22306510)
RGD
PMID:22306510
NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615
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Adcy10
adenylate cyclase 10
IMP
RGD
PMID:28386847
RGD:329337357
NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
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Adgrb1
adhesion G protein-coupled receptor B1
involved_in
ISO IEA
(PMID:26838550) GO_REF:0000107
RGD Ensembl
PMID:26838550
GO_REF:0000107
NCBI chr 7:106,404,827...106,476,902
Ensembl chr 7:106,404,958...106,476,902
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Alox12
arachidonate 12-lipoxygenase, 12S type
IMP
RGD
PMID:15450084
RGD:2313867
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Cd36
CD36 molecule
involved_in
ISO IEA
(MGI:4438693|PMID:20037584) GO_REF:0000107 (PMID:20037584)
RGD Ensembl
PMID:20037584
GO_REF:0000107 MGI:4438693
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Clcn3
chloride voltage-gated channel 3
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2447864 (PMID:16522634)
Ensembl RGD
PMID:16522634
GO_REF:0000107
NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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Cyba
cytochrome b-245 alpha chain
involved_in
ISO IEA
(PMID:22423966) GO_REF:0000107
RGD Ensembl
PMID:22423966
GO_REF:0000107
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Foxo3
forkhead box O3
IMP
RGD
PMID:24278276
RGD:10402204
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
involved_in
IGI
PMID:17308309
ARUK-UCL
PMID:17308309
RGD:12910994
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Hdac4
histone deacetylase 4
IMP
RGD
PMID:24166750
RGD:9681442
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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Il4
interleukin 4
IDA
RGD
PMID:24073824
RGD:10402792
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Lcn2
lipocalin 2
IDA
RGD
PMID:25557118
RGD:126790477
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Mfn2
mitofusin 2
IMP
RGD
PMID:27997345
RGD:12910740
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mir24-2
microRNA 24-2
involved_in
ISO
(PMID:21788589)
RGD
PMID:21788589
NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790
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Mir675
microRNA 675
acts_upstream_of
ISO
(PMID:31574452)
RGD
PMID:31574452
NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358
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Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase
IMP
RGD
PMID:21712532
RGD:9590189
NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146
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Park7
Parkinsonism associated deglycase
acts_upstream_of_or_within
ISO
(PMID:22555455)
RGD
PMID:22555455
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Plcg2
phospholipase C, gamma 2
acts_upstream_of involved_in
ISO IEA
(MGI:5300086|PMID:22041900) GO_REF:0000107
RGD Ensembl
PMID:22041900
GO_REF:0000107 MGI:5300086
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Rab27a
RAB27A, member RAS oncogene family
involved_in
ISO
(PMID:24404184)
RGD
PMID:24404184
NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
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Slc5a3
solute carrier family 5 member 3
acts_upstream_of_or_within
ISO
(MGI:6414721|PMID:28128227)
RGD
PMID:28128227
MGI:6414721
NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
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Tlr4
toll-like receptor 4
involved_in
ISO IEA
(MGI:4438693|PMID:20037584) GO_REF:0000107
RGD Ensembl
PMID:20037584
GO_REF:0000107 MGI:4438693
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr6
toll-like receptor 6
involved_in
ISO
(MGI:4438693|PMID:20037584)
RGD
PMID:20037584
MGI:4438693
NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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Alox5
arachidonate 5-lipoxygenase
involved_in
IEA ISO ISS
GO_REF:0000107 (PMID:26210919) GO_REF:0000024
Ensembl RGD UniProt
PMID:26210919
GO_REF:0000024 GO_REF:0000107
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Arg2
arginase 2
involved_in
IEA ISO
GO_REF:0000107 (MGI:5810834|PMID:27214549) (PMID:27214549)
Ensembl RGD
PMID:27214549
GO_REF:0000107 MGI:5810834
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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Ccn6
cellular communication network factor 6
involved_in
ISO
(PMID:27252383)
RGD
PMID:27252383
NCBI chr20:42,569,309...42,585,126
Ensembl chr20:42,569,309...42,585,126
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Hvcn1
hydrogen voltage-gated channel 1
involved_in
ISO
(PMID:30478045) (PMID:24415791) (MGI:6843609|PMID:24415791)
RGD
PMID:24415791 PMID:30478045
MGI:6843609
NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
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Ncf2
neutrophil cytosolic factor 2
IMP
RGD
PMID:27279484
RGD:151347625
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
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Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
involved_in
ISO IBA
(PMID:28779020) GO_REF:0000033 (MGI:6103777|PMID:28779020)
RGD GO_Central
PMID:28779020
GO_REF:0000033 MGI:6103777
NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868
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Slc25a33
solute carrier family 25 member 33
involved_in
ISO
(PMID:20453889)
RGD
PMID:20453889
NCBI chr 5:160,195,040...160,219,961
Ensembl chr 5:160,195,042...160,219,961
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Sphk2
sphingosine kinase 2
involved_in
ISO
(MGI:5641585|PMID:25637806)
RGD
PMID:25637806
MGI:5641585
NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
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Ucp1
uncoupling protein 1
involved_in
NAS ISO
PMID:20416274 (PMID:20416274) (MGI:4837058|PMID:20416274)
RGD
PMID:20416274 PMID:20416274
MGI:4837058 , RGD:11541111
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all