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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of regulated secretory pathway
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Accession:GO:1903307 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: up regulation of regulated secretory pathway;   upregulation of regulated secretory pathway
 narrow_synonym: activation of regulated secretory pathway


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positive regulation of regulated secretory pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab15 RAB15, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004936495:8,590,844...8,622,655 JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004936471:16,738,204...16,815,561 JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004936596:2,990,367...2,995,935 JBrowse link
G Rab3d RAB3D, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004936659:1,429,562...1,438,876 JBrowse link
G Unc13d unc-13 homolog D involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004936594:1,008,215...1,023,023 JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISO (MGI:4834982|PMID:20586096) UniProt PMID:20586096 MGI:4834982 NCBI chrNW_004936529:1,831,639...1,837,314 JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO (PMID:19004505)
(PMID:19246320)
UniProt PMID:19004505 PMID:19246320 NCBI chrNW_004936543:2,013,231...2,022,270 JBrowse link
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP ribosylation factor 1 ISO RGD PMID:10657240 RGD:9684853 NCBI chrNW_004936864:117,510...119,612 JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:17172292 RGD:2316206 NCBI chrNW_004936490:11,093,600...11,157,756 JBrowse link
G Cadps calcium dependent secretion activator ISO RGD PMID:9289490 RGD:1299539 NCBI chrNW_004936637:3,543,615...4,023,710 JBrowse link
G Cdk5 cyclin dependent kinase 5 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G Cdk5r2 cyclin dependent kinase 5 regulatory subunit 2 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chrNW_004936569:1,381,101...1,383,593 JBrowse link
G Doc2b double C2 domain beta involved_in ISO PMID:18596155 UniProt PMID:18596155 RGD:8554556 NCBI chrNW_004936538:7,461,030...7,486,648 JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in ISO PMID:18167541
PMID:17301173
PMID:20484665
UniProt PMID:17301173 PMID:18167541 PMID:20484665 RGD:10047179 RGD:10047360 RGD:10047384 NCBI chrNW_004936514:4,827,156...4,902,271 JBrowse link
G Scamp5 secretory carrier membrane protein 5 involved_in ISO (PMID:19234194) UniProt PMID:19234194 NCBI chrNW_004936471:33,936,721...33,958,439 JBrowse link
G Stx1a syntaxin 1A involved_in ISO PMID:17301173
PMID:18167541
PMID:20484665
UniProt PMID:17301173 PMID:18167541 PMID:20484665 RGD:10047179 RGD:10047360 RGD:10047384 NCBI chrNW_004936543:2,909,560...2,918,175 JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chrNW_004936487:15,300,758...15,367,475 JBrowse link
G Syt1 synaptotagmin 1 ISO RGD PMID:21551071 RGD:7205660 NCBI chrNW_004936698:65,210...575,538 JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (MGI:5751674|PMID:21496647) UniProt PMID:21496647 MGI:5751674 NCBI chrNW_004936607:2,940,607...2,995,178 JBrowse link
G Syt7 synaptotagmin 7 ISO RGD PMID:21551071 RGD:7205660 NCBI chrNW_004936581:1,516,199...1,557,992 JBrowse link
G Syt9 synaptotagmin 9 ISO RGD PMID:21551071 RGD:7205660 NCBI chrNW_004936841:542,211...706,272 JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISO (MGI:2179533|PMID:11242035) UniProt PMID:11242035 MGI:2179533 NCBI chrNW_004936698:65,210...575,538 JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chrNW_004936517:3,035,840...3,044,065 JBrowse link
positive regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:11714832) UniProt PMID:11714832 NCBI chrNW_004936549:142,281...153,575 JBrowse link
G Stx4 syntaxin 4 involved_in ISO (PMID:16677249) UniProt PMID:16677249 NCBI chrNW_004936501:13,401,095...13,408,316 JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Pla2g3 phospholipase A2 group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)
UniProt PMID:23624557 MGI:5492190 NCBI chrNW_004936755:307,166...312,683 JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004937215:127,074...137,281 JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004936958:345,055...393,384 JBrowse link
G Vamp8 vesicle associated membrane protein 8 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004936712:1,688,126...1,689,742 JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2b receptor acts_upstream_of_or_within ISO (MGI:3776334|PMID:11454903) MGI PMID:11454903 MGI:3776334 NCBI chrNW_004936821:583,463...608,189 JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:18209484 RGD:5130941 NCBI chrNW_004936541:2,288,847...2,333,129 JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) MGI PMID:9000133 MGI:85068 NCBI chrNW_004936740:1,201,370...1,206,871 JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (MGI:3029067|PMID:14764707) MGI PMID:14764707 MGI:3029067 NCBI chrNW_004936903:514,278...517,975 JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:5294498|PMID:21746961) UniProt PMID:21746961 MGI:5294498 NCBI chrNW_004936474:11,897,998...11,919,153 JBrowse link
G Gab2 GRB2 associated binding protein 2 involved_in ISO (MGI:2137187|PMID:11449275) UniProt PMID:11449275 MGI:2137187 NCBI chrNW_004936498:6,775,170...6,835,680 JBrowse link
G Gata1 GATA binding protein 1 ISO RGD PMID:22390417 RGD:9587812 NCBI chrNW_004936721:742,862...750,843 JBrowse link
G Gata2 GATA binding protein 2 ISO RGD PMID:22390417 RGD:9587812 NCBI chrNW_004936798:406,258...414,785 JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO (MGI:3589858|PMID:15944273) MGI PMID:15944273 MGI:3589858 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3589858|PMID:15944273) MGI PMID:15944273 MGI:3589858 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G LOC101973578 adenosine receptor A3 acts_upstream_of_or_within ISO (MGI:2664591|PMID:12817016) MGI PMID:12817016 MGI:2664591 NCBI chrNW_004936690:152,777...168,411 JBrowse link
G Ms4a2 membrane spanning 4-domains A2 ISO RGD PMID:16177098 RGD:1578516 NCBI chrNW_004936581:2,743,133...2,751,925 JBrowse link
G Nppc natriuretic peptide C involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chrNW_004936525:5,092,675...5,099,344 JBrowse link
G Pld2 phospholipase D2 ISO RGD PMID:16861349 RGD:2299903 NCBI chrNW_004936677:2,870,664...2,883,545 JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) UniProt PMID:17346996 MGI:3703830 NCBI chrNW_004936664:2,668,708...2,676,608 JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO RGD PMID:23487749 RGD:12904029 NCBI chrNW_004936487:15,300,758...15,367,475 JBrowse link
G Stxbp2 syntaxin binding protein 2 ISO RGD PMID:23487749 RGD:12904029 NCBI chrNW_004936588:4,688,221...4,696,075 JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD
MGI
PMID:9000133 PMID:16861349 MGI:85068 RGD:2299903 NCBI chrNW_004936780:1,553,605...1,601,036 JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004936475:21,983,248...22,063,133 JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chrNW_004936867:478,625...485,905 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004936472:377,359...389,121 JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004936706:630,098...637,775 JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004936543:8,460,526...8,508,524 JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G Ptafr platelet activating factor receptor ISO RGD PMID:2829894 RGD:10041060 NCBI chrNW_004936474:12,333,905...12,337,140 JBrowse link
positive regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Dnm1l dynamin 1 like involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936607:3,576,357...3,632,423 JBrowse link
G Nlgn1 neuroligin 1 involved_in ISO PMID:19628693
(MGI:4355770|PMID:19628693)
BHF-UCL PMID:19628693 MGI:4355770 RGD:8554760 NCBI chrNW_004936703:951,935...1,415,991 JBrowse link
G Slc4a8 solute carrier family 4 member 8 acts_upstream_of_or_within ISO (MGI:5013899|PMID:21593314) ARUK-UCL PMID:21593314 MGI:5013899 NCBI chrNW_004936512:8,988,212...9,060,287 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12295
    positive regulation of biological process 5610
      positive regulation of cellular process 5194
        positive regulation of secretion by cell 344
          positive regulation of exocytosis 93
            positive regulation of regulated secretory pathway 57
              positive regulation of calcium ion-dependent exocytosis + 17
              positive regulation of leukocyte degranulation + 32
              positive regulation of synaptic vesicle exocytosis + 5
Path 2
Term Annotations click to browse term
  biological_process 12295
    localization 4949
      establishment of localization 3526
        transport 3365
          secretion 969
            secretion by cell 825
              exocytosis 328
                regulated exocytosis 249
                  regulation of regulated secretory pathway 166
                    positive regulation of regulated secretory pathway 57
                      positive regulation of calcium ion-dependent exocytosis + 17
                      positive regulation of leukocyte degranulation + 32
                      positive regulation of synaptic vesicle exocytosis + 5
paths to the root